Chiral ION-QN & Chiral ION-QD HPLC columns - Transform Your Chiral Analysis

Chiral ION-QN & Chiral ION-QD

Weak Anion-Exchanger (WAX) stationary phases for reliable chiral separation of acidic compounds

Transform Your Chiral Analysis

One of the main challenges of today’s liquid chromatography is chiral separation of ionised and ionisable analytes, e.g., organic acids, amino acids, N-protected amino acids, amino acid mimics, etc. The most efficient approach to purify and resolve such troublesome racemates utilises ion exchange-type stationary phases that facilitate strong interactions between the chiral selector and the analyte.

Galochrom introduces its own generic series of weak anion-exchangers, based on tert-butyl-carbamoylated Cinchona alkaloids quinine (QN) and quinidine (QD). These chiral phases have demonstrated excellent selectivity and improved peak resolution, resulting in highly accurate and replicable analyses. Our innovative manufacturing and strict quality control ensure that these generic columns not only outperform commercial alternatives, but also meet your technical requirements.

Chiral ION-QN & Chiral ION-QD represent the most efficient approach to purify and resolve even the most challenging mixtures.

Applications

Chiral ION-QN & Chiral ION-QD are ideal for enantioseparations of:

• N-protected amino acids
• Aminophosphonic & Aminosulfonic acids
• Lactic & Thiolactic acids
• Clenbuterol & Thyroxin

Upgrade your separation performance and gain:

• Premium enantioselectivity
• Elegant switch of the elution order of enantiomers
• High-stability against all common HPLC solvents
• Seamless method transfer

Powerful Selectivity

Aim for the best resolution and selectivity possible

In collaboration with dozens of researchers, we have selected the best-performing derivatives of both quinine (QN) and quinidine (QD). As a result, the Chiral ION-QN features O-9-(tert-butylcarbamoyl)quinine, which is immobilized on fully-porous spherical silica (see below). The unique chiral scaffold of the cinchona backbone provides exceptional selectivity for wide array of acidic compounds.

The Chiral ION-QD features structurally similar selector to Chiral ION-QN. As a result, these selectors, while being diastereomers, act as pseudo-enantiomers. This feature enables elegant switch of elution order of enantiomers, which is often challenging for other chiral stationary phases.

Galochrom: Chiral ION-QN & Chiral ION-QD HPLC columns - Transform Your Chiral Analysis.

Molecular recognition

The prime driving force for specific molecular association are electrostatic or ionic interactions. Once analyte reaches close proximity of the selector, weaker non-bonding interactions such as H-bonding, π−π stacking and steric interactions apply. These directive interactions result in different column retention per each enantiomer.

Since analytes differ in combination and strength of these binding increments, our chiral stationary phase delivers superior molecular recognition.

Supporting professionals across many industries

• Forensic Science
• Chemical Manufacturing
• Biotechnology
• Agriculture
• Academic Research 
• Pharmaceuticals
• Food & Quality Control

Popular chiral columns

Essential tools with a wide range of applications

Find your best match

There are hundreds of chiral stationary phases available on the market. The selection of chiral HPLC columns below represents the most popular and top-performing choices for analysis and resolution of chiral acidic compounds. Displayed data are relevant to analytical and semi-preparative scale

Galochrom: Chiral ION-QN & Chiral ION-QD HPLC columns - Transform Your Chiral Analysis.

Take Full Advantage Of Unique Selectivity And Expand Your Research Possibilities

Chiral ION-QN & Chiral ION-QD now available at ANALYTICAL & PREPARATIVE scale

Order information

Analytical Columns

Chiral ION-QN

• Dimensions [mm]: 150 x 3
• Porosity: [Å] 200
• Cat. No.: ION01-A150
• Price [€]: 1 300

Chiral ION-QD

• Dimensions [mm]: 150 x 3
• Porosity: [Å] 200
• Cat. No.: ION02-A150
• Price [€]: 1 300

*As an alternative, we can also offer 150x3 mm, 3 μm with 120 Å

Preparative Columns

Chiral ION-QN

• Dimensions [mm]: 150 x 20
  • Porosity: [Å] 120
  • Cat. No.: ION03-P150
  • Price [€]: 9 800
• Dimensions [mm]: 250 x 20
  • Porosity: [Å] 120
  • Cat. No.: ION04-P250
  • Price [€]: 11 300

Chiral ION-QD

• Dimensions [mm]: 150 x 20
  • Porosity: [Å] 120
  • Cat. No.: ION05-P150
  • Price [€]: 9 800
• Dimensions [mm]: 250 x 20
  • Porosity: [Å] 120
  • Cat. No.: ION06-P250
  • Price [€]: 11 300

SPECIAL OFFER 1+1

Buy 1 preparative column and get analytical column for FREE

You can choose 150x4 or 250x4 column with the same sorbent as your preparative column.