LCMS
More information
WebinarsAbout usContact usTerms of use
LabRulez s.r.o. All rights reserved. Content available under a CC BY-SA 4.0 Attribution-ShareAlike
Author
Wiley
Wiley
For over 200 years we have been helping people and organizations develop the skills and knowledge they need to succeed. We develop digital education, learning, assessment, and certification solutions to help universities, businesses, and individuals move between education and employment and achieve their ambitions.
Tags
Article
Product
Software
Video
LinkedIn Logo

KnowItAll 2026.1 maintenance release now available - Upgrade for the latest features and fixes

Tu, 13.1.2026
| Original article from: Wiley
KnowItAll 2026.1 maintenance release brings LC-MS deconvolution improvements, updated DEA rulebases, and bug fixes to enhance spectral analysis workflows and performance.
Video placeholder
  • Photo: Wiley: KnowItAll 2026.1 maintenance release now available—Upgrade for the latest features and fixes
  • Video: Wiley Spectroscopy: WEBINAR: What's New in KnowItAll 2026 - Oct 2025

We are pleased to announce that a maintenance release is now available for KnowItAll 2026. Maintenance releases are an important way to introduce improvements and bug fixes between major releases to make sure users get the most out of KnowItAll.

In Fall 2025, we announced the KnowItAll 2026 major release featuring a new principal component analysis tool, Trendfinder, and various advances for spectral analysis workflows. This is the first update available after that release.

Updates in the 2026.1 maintenance release include:
  • Continued to LC-MS deconvolution improvement
  • Updated the DEA regulations rulebase that’s used to automatically categorize structures in databases you build in MineIt according to current Drug Enforcement Agency controlled substance regulations.
  • Various bug fixes

We encourage users to update now to the most recent version of the software to ensure the best performance.

About KnowItAll

KnowItAll Software offers solutions to analyze and manage multiple types of spectral and chemical data in multiple file and instrument formats. KnowItAll's integrated toolsets eliminate the need for multiple software packages and increase overall lab efficiency and staff proficiency. Combined with Wiley’s comprehensive, high-quality spectral reference libraries, it provides an unparalleled solution for fast, reliable spectral analysis. Learn more.

About Wiley

Wiley (NYSE: WLY) is a global leader in authoritative content and research intelligence for the advancement of scientific discovery, innovation, and learning. With more than 200 years at the center of the scholarly ecosystem, Wiley combines trusted publishing heritage with AI-powered platforms to transform how knowledge is discovered, accessed, and applied. From individual researchers and students to Fortune 500 R&D teams, Wiley enables the transformation of scientific breakthroughs into real-world impact. From knowledge to impact—Wiley is redefining what's possible in science and learning. Visit us at Wiley.com and Investors.Wiley.com. Follow us on Facebook, X, LinkedIn and Instagram.

Wiley
LinkedIn Logo
 

Related content

Determination of Authenticity of Manuka Honey Using the MALDI-8030 Benchtop Linear MALDI-TOF Mass Spectrometer

Applications
| 2026 | Shimadzu
Instrumentation
MALDI, LC/MS, LC/TOF
Manufacturer
Shimadzu
Industries
Food & Agriculture

Analysis of Inorganic Anions in Drinking Water According to EPA Method 300.1 Using Nexera IC -Part A

Applications
| 2026 | Shimadzu
Instrumentation
Ion chromatography
Manufacturer
Shimadzu
Industries
Food & Agriculture

Quality Evaluation of mRNA by Electrophoresis

Applications
| 2026 | Shimadzu
Instrumentation
Capillary electrophoresis
Manufacturer
Shimadzu
Industries
Pharma & Biopharma

LC/MS dMRM Method Refinement Expands Targeted Lipidomics Studies from Plasma to Cells and Tissues

Applications
| 2026 | Agilent Technologies
Instrumentation
LC/MS, LC/MS/MS, LC/QQQ
Manufacturer
Agilent Technologies
Industries
Lipidomics, Clinical Research

Sensitive Detection of Aflatoxins by the Agilent 1290 Infinity III Fluorescence Detector

Applications
| 2026 | Agilent Technologies
Instrumentation
HPLC
Manufacturer
Agilent Technologies
Industries
Food & Agriculture
 

Related articles

Introducing the new Thermo Scientific TSQ Certis Triple Quadrupole Mass Spectrometer
Article | Product

Introducing the new Thermo Scientific TSQ Certis Triple Quadrupole Mass Spectrometer

Thermo Scientific TSQ Certis Triple Quadrupole MS delivers rugged uptime, next-gen quantitative performance, and high-throughput LC-MS/MS for routine, clinical, PFAS, and biopharma labs.
Thermo Fisher Scientific
tag
share
more
ISC 2026 Deadline for abstract submission
Article | Events

ISC 2026 Deadline for abstract submission

Only 8 days left to submit your abstract for an oral presentation at ISC 2026 in Prague. Secure your slot—and your chance to present in Tutorials & Young Speakers.
International Symposium on Chromatography - (ISC)
tag
share
more
Oligos Made Easy - Part 5: SEC
Article | Academy

Oligos Made Easy - Part 5: SEC

Learn how SEC streamlines oligonucleotide purification. From pore size selection to flow optimization, discover practical tips for desalting, buffer exchange, and clean size-based separation.
KNAUER
tag
share
more
News from LabRulezLCMS Library - Week 10, 2026
Article | Application

News from LabRulezLCMS Library - Week 10, 2026

This week we bring you application notes by KNAUER, Shimadzu, Thermo Fisher Scientific and Waters Corporation and technical note by Agilent Technologies!
LabRulez
tag
share
more
 

Related content

Determination of Authenticity of Manuka Honey Using the MALDI-8030 Benchtop Linear MALDI-TOF Mass Spectrometer

Applications
| 2026 | Shimadzu
Instrumentation
MALDI, LC/MS, LC/TOF
Manufacturer
Shimadzu
Industries
Food & Agriculture

Analysis of Inorganic Anions in Drinking Water According to EPA Method 300.1 Using Nexera IC -Part A

Applications
| 2026 | Shimadzu
Instrumentation
Ion chromatography
Manufacturer
Shimadzu
Industries
Food & Agriculture

Quality Evaluation of mRNA by Electrophoresis

Applications
| 2026 | Shimadzu
Instrumentation
Capillary electrophoresis
Manufacturer
Shimadzu
Industries
Pharma & Biopharma

LC/MS dMRM Method Refinement Expands Targeted Lipidomics Studies from Plasma to Cells and Tissues

Applications
| 2026 | Agilent Technologies
Instrumentation
LC/MS, LC/MS/MS, LC/QQQ
Manufacturer
Agilent Technologies
Industries
Lipidomics, Clinical Research

Sensitive Detection of Aflatoxins by the Agilent 1290 Infinity III Fluorescence Detector

Applications
| 2026 | Agilent Technologies
Instrumentation
HPLC
Manufacturer
Agilent Technologies
Industries
Food & Agriculture
 

Related articles

Introducing the new Thermo Scientific TSQ Certis Triple Quadrupole Mass Spectrometer
Article | Product

Introducing the new Thermo Scientific TSQ Certis Triple Quadrupole Mass Spectrometer

Thermo Scientific TSQ Certis Triple Quadrupole MS delivers rugged uptime, next-gen quantitative performance, and high-throughput LC-MS/MS for routine, clinical, PFAS, and biopharma labs.
Thermo Fisher Scientific
tag
share
more
ISC 2026 Deadline for abstract submission
Article | Events

ISC 2026 Deadline for abstract submission

Only 8 days left to submit your abstract for an oral presentation at ISC 2026 in Prague. Secure your slot—and your chance to present in Tutorials & Young Speakers.
International Symposium on Chromatography - (ISC)
tag
share
more
Oligos Made Easy - Part 5: SEC
Article | Academy

Oligos Made Easy - Part 5: SEC

Learn how SEC streamlines oligonucleotide purification. From pore size selection to flow optimization, discover practical tips for desalting, buffer exchange, and clean size-based separation.
KNAUER
tag
share
more
News from LabRulezLCMS Library - Week 10, 2026
Article | Application

News from LabRulezLCMS Library - Week 10, 2026

This week we bring you application notes by KNAUER, Shimadzu, Thermo Fisher Scientific and Waters Corporation and technical note by Agilent Technologies!
LabRulez
tag
share
more
 

Related content

Determination of Authenticity of Manuka Honey Using the MALDI-8030 Benchtop Linear MALDI-TOF Mass Spectrometer

Applications
| 2026 | Shimadzu
Instrumentation
MALDI, LC/MS, LC/TOF
Manufacturer
Shimadzu
Industries
Food & Agriculture

Analysis of Inorganic Anions in Drinking Water According to EPA Method 300.1 Using Nexera IC -Part A

Applications
| 2026 | Shimadzu
Instrumentation
Ion chromatography
Manufacturer
Shimadzu
Industries
Food & Agriculture

Quality Evaluation of mRNA by Electrophoresis

Applications
| 2026 | Shimadzu
Instrumentation
Capillary electrophoresis
Manufacturer
Shimadzu
Industries
Pharma & Biopharma

LC/MS dMRM Method Refinement Expands Targeted Lipidomics Studies from Plasma to Cells and Tissues

Applications
| 2026 | Agilent Technologies
Instrumentation
LC/MS, LC/MS/MS, LC/QQQ
Manufacturer
Agilent Technologies
Industries
Lipidomics, Clinical Research

Sensitive Detection of Aflatoxins by the Agilent 1290 Infinity III Fluorescence Detector

Applications
| 2026 | Agilent Technologies
Instrumentation
HPLC
Manufacturer
Agilent Technologies
Industries
Food & Agriculture
 

Related articles

Introducing the new Thermo Scientific TSQ Certis Triple Quadrupole Mass Spectrometer
Article | Product

Introducing the new Thermo Scientific TSQ Certis Triple Quadrupole Mass Spectrometer

Thermo Scientific TSQ Certis Triple Quadrupole MS delivers rugged uptime, next-gen quantitative performance, and high-throughput LC-MS/MS for routine, clinical, PFAS, and biopharma labs.
Thermo Fisher Scientific
tag
share
more
ISC 2026 Deadline for abstract submission
Article | Events

ISC 2026 Deadline for abstract submission

Only 8 days left to submit your abstract for an oral presentation at ISC 2026 in Prague. Secure your slot—and your chance to present in Tutorials & Young Speakers.
International Symposium on Chromatography - (ISC)
tag
share
more
Oligos Made Easy - Part 5: SEC
Article | Academy

Oligos Made Easy - Part 5: SEC

Learn how SEC streamlines oligonucleotide purification. From pore size selection to flow optimization, discover practical tips for desalting, buffer exchange, and clean size-based separation.
KNAUER
tag
share
more
News from LabRulezLCMS Library - Week 10, 2026
Article | Application

News from LabRulezLCMS Library - Week 10, 2026

This week we bring you application notes by KNAUER, Shimadzu, Thermo Fisher Scientific and Waters Corporation and technical note by Agilent Technologies!
LabRulez
tag
share
more
 

Related content

Determination of Authenticity of Manuka Honey Using the MALDI-8030 Benchtop Linear MALDI-TOF Mass Spectrometer

Applications
| 2026 | Shimadzu
Instrumentation
MALDI, LC/MS, LC/TOF
Manufacturer
Shimadzu
Industries
Food & Agriculture

Analysis of Inorganic Anions in Drinking Water According to EPA Method 300.1 Using Nexera IC -Part A

Applications
| 2026 | Shimadzu
Instrumentation
Ion chromatography
Manufacturer
Shimadzu
Industries
Food & Agriculture

Quality Evaluation of mRNA by Electrophoresis

Applications
| 2026 | Shimadzu
Instrumentation
Capillary electrophoresis
Manufacturer
Shimadzu
Industries
Pharma & Biopharma

LC/MS dMRM Method Refinement Expands Targeted Lipidomics Studies from Plasma to Cells and Tissues

Applications
| 2026 | Agilent Technologies
Instrumentation
LC/MS, LC/MS/MS, LC/QQQ
Manufacturer
Agilent Technologies
Industries
Lipidomics, Clinical Research

Sensitive Detection of Aflatoxins by the Agilent 1290 Infinity III Fluorescence Detector

Applications
| 2026 | Agilent Technologies
Instrumentation
HPLC
Manufacturer
Agilent Technologies
Industries
Food & Agriculture
 

Related articles

Introducing the new Thermo Scientific TSQ Certis Triple Quadrupole Mass Spectrometer
Article | Product

Introducing the new Thermo Scientific TSQ Certis Triple Quadrupole Mass Spectrometer

Thermo Scientific TSQ Certis Triple Quadrupole MS delivers rugged uptime, next-gen quantitative performance, and high-throughput LC-MS/MS for routine, clinical, PFAS, and biopharma labs.
Thermo Fisher Scientific
tag
share
more
ISC 2026 Deadline for abstract submission
Article | Events

ISC 2026 Deadline for abstract submission

Only 8 days left to submit your abstract for an oral presentation at ISC 2026 in Prague. Secure your slot—and your chance to present in Tutorials & Young Speakers.
International Symposium on Chromatography - (ISC)
tag
share
more
Oligos Made Easy - Part 5: SEC
Article | Academy

Oligos Made Easy - Part 5: SEC

Learn how SEC streamlines oligonucleotide purification. From pore size selection to flow optimization, discover practical tips for desalting, buffer exchange, and clean size-based separation.
KNAUER
tag
share
more
News from LabRulezLCMS Library - Week 10, 2026
Article | Application

News from LabRulezLCMS Library - Week 10, 2026

This week we bring you application notes by KNAUER, Shimadzu, Thermo Fisher Scientific and Waters Corporation and technical note by Agilent Technologies!
LabRulez
tag
share
more
Other projects
GCMS
ICPMS
Follow us
FacebookX (Twitter)LinkedInYouTube
More information
WebinarsAbout usContact usTerms of use
LabRulez s.r.o. All rights reserved. Content available under a CC BY-SA 4.0 Attribution-ShareAlike