ISC 2026 Short Course 4 - Hydrophilic Interaction Liquid Chromatography
International Symposium on Chromatography: ISC 2026 Short Course 4 - Hydrophilic Interaction Liquid Chromatography
ISC 2026
The International Symposium on Chromatography (ISC) represents the oldest conference series on separation science. ISC symposia have been organised since 1956 in each even year. ISC is one of the premier meetings series for discussion of all modes of chromatography and separation science with a broad coverage of techniques and applications.
The major focus of the symposium will be on the impact of chromatography and separation science to meet the needs of the pharmaceutical, environmental, food and health industry, as well as science and medicine. The symposium programme will reflect these themes and highlight new challenges and emerging opportunities for the science and marketing of separation and detection systems and methods.
As an integral part of the scientific programme of lectures and poster sessions, an international exhibition and vendor seminars on instrumentation and services for chromatography, separation science and mass spectrometry will be organised. ISC 2026 will provide the perfect forum for attendees from academia, industry and government research institutions for scientific exchange and networking.
ISC 2026 SYMPOSIUM KEY DATES
6-10 SEPTEMBER 2026
- 15 January 2026: Opening of Early-bird Registration & Abstract submission
- 11 March 2026: Deadline for abstract submission (orals)
- 21 April 2026: Sending acceptance letters (orals)
- 15 May 2026: Deadline of early-bird registration and payment & Author registration deadline (orals)
- 1 June 2026: Preliminary detailed program on web
- 1 June 2026: Deadline for abstract submission (posters)
- 16 June 2026: Sending acceptance letters (posters)
- Authors who submit their abstracts with a poster preference by 5 May 2026 will be notified of the outcome by 12 May 2026 and will have the opportunity to register at the early-bird rate until 15 May 2026.
- 30 June 2026: Author registration deadline (posters)
- 30 July 2026: Deadline for abstract submission (late-breaking posters)
- without the possibility of competing for the Best Poster Award
- 11 August 2026: Sending acceptance letters (late-breaking posters)
- 18 August 2026: Author registration deadline (late-breaking posters)
- 25 August 2026: Deadline for late registration & payment
- 6-10 September 2026: Symposium
REGISTRATION
ABSTRACT SUBMISSION
SCIENTIFIC PROGRAM
SHORT COURSES
SC 4 Hydrophilic Interaction Liquid Chromatography
🗓️ SUNDAY, 6 SEPTEMBER 2026
🕗 8:30 – 11:45
Hydrophilic Interaction Chromatography (HILIC) has become an essential separation mode for the analysis of polar compounds that are poorly retained in reversed-phase LC. This chromatographic mode is more and more widely used in pharmaceutical analysis, biopharmaceutical characterization, and, above all, metabolomics, where enhanced retention, improved MS sensitivity, and complementary selectivity are indispensable. Despite its power, HILIC remains perceived as complex due to its mixed retention mechanisms, sensitivity to experimental conditions, and limited repeatability. A dedicated short course is therefore required to help users understand this technique in a robust and efficient way.
This course will provide an in-depth and practical overview of HILIC fundamentals, starting with a discussion of the relatively complex retention mechanism. Particular emphasis will be placed on critical operational parameters such as sample diluent effects, which can drastically impact peak shape and retention, and on achieving good repeatability in gradient mode.
Participants will also learn how coupling HILIC with MS can maximize sensitivity, and how to select both mobile phase components and stationary phases to obtain reliable and reproducible separations. Numerous applications will be covered, including typical small-molecule analyses, comprehensive metabolomic workflows, and the characterization of large biopolymers such as oligonucleotides, peptides, and proteins.
In the end, this short course will help participants to confidently implement and troubleshoot HILIC in modern analytical laboratories.
Lecturers
Davy Guillarme
- Davy Guillarme currently serves as an associate professor at the University of Geneva in Switzerland. With over 350 published journal his expertise spans various techniques, including UHPLC, HILIC, LC−MS, SFC, SFC-MS, multidimensional LC, and application to the characterization of biopharmaceuticals.
- He is an editor of the Journal of Chromatography A and serves on the editorial advisory board of various other journals.
- Davy Guillarme has been honored with the LC-GC Emerging Leader Award in Chromatography (2013), the Jubilee Medal from the Chromatographic Society (2018), the International Award of the Belgian Society of Pharmaceutical Sciences (2022) and the Csaba Horvath memorial award (2025).
ISC 2026: Davy Guillarme
