<p><strong>From September to December 2025, the LC/MS community worldwide will gather for a wide range of scientific conferences, courses, and training opportunities. These events provide a chance to explore new analytical techniques, discover emerging applications, and exchange experiences with peers across academia, industry, and regulatory sectors.</strong></p><h5><strong>Shimadzu at 10th Lipidomics Forum</strong></h5><ul><li>14–17 September 2025 | Vienna, Austria</li><li><strong>Organizer:</strong> Shimadzu Corporation</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/907">More information and registration at this link</a></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Shimadzu_at_10th_Lipidomics_Forum_aae43f6640.jpg" alt="Shimadzu: Shimadzu at 10th Lipidomics Forum" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Shimadzu_at_10th_Lipidomics_Forum_aae43f6640.jpg 245w," sizes="100vw" width="1390" height="390"></p><h5><strong>10th Lipidomics Forum</strong></h5><ul><li>14–17 September 2025 | Vienna, Austria</li><li><strong>Organizer: </strong>University of Vienna</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/896">More information and registration at this link</a></li></ul><h5><strong>14th International Conference on Instrumental Methods of Analysis (IMA-2025)</strong></h5><ul><li>14–17 September 2025 | Kefalonia, Greece</li><li><strong>Organizer:</strong> National Technical University of Athens</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/795">More information and registration at this link</a></li></ul><h5><strong>Course: Optimization of Pharmacopeia Methods in QC</strong></h5><ul><li>15–16 September 2025 | Online</li><li>Organizer: Phenomenex</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/743">More information and registration at this link</a></li></ul><h5><strong>53rd Conference on Synthesis and Analysis of Drugs 2025</strong></h5><ul><li>17–19 September 2025 | Kurdějov, Czech Republic</li><li><strong>Organizer: </strong>Masaryk University</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/678">More information and registration at this link</a></li></ul><h5><strong>21th ISC ‘Modern Analytical Chemistry’</strong></h5><ul><li>18–19 September 2025 | Prague, Czech Republic</li><li><strong>Organizer: </strong>European Chemical Society (EuChemS)</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/839">More information and registration at this link</a></li></ul><h5><strong>MSACL 2025 – 15th Annual Conference &amp; Exhibits</strong></h5><ul><li>21–26 September 2025 | Montréal, Canada</li><li><strong>Organizer:</strong> MSACL</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/731">More information and registration at this link</a></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/MSACL_2025_cover_image_762faaf59f.jpg" alt="MSACL 2025 – 15th Annual Conference &amp; Exhibits" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_MSACL_2025_cover_image_762faaf59f.jpg 245w," sizes="100vw" width="1920" height="1080"></p><h5><strong>7th International Mass Spectrometry School (IMSS) 2025</strong></h5><ul><li>21–26 September 2025 | Vorau, Styria, Austria</li><li><strong>Organizer:</strong> International Mass Spectrometry Foundation</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/906">More information and registration at this link</a></li></ul><h5><strong>Mass Spectrometry Symposium 2025</strong></h5><ul><li>23–26 September 2025 | Costa Mesa, CA, USA</li><li><strong>Organizer: </strong>Local MS societies (CASSS)</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/897">More information and registration at this link</a></li></ul><h5><strong>ISSS 2025 – 29th International Symposium on Separation Sciences</strong></h5><ul><li>25–27 September 2025 | Belgrade, Serbia</li><li><strong>Organizer:</strong> International Symposium on Separation Sciences (ISSS)</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/730">More information and registration at this link</a></li></ul><h5><strong>GDCh Science Forum Chemistry 2025</strong></h5><ul><li>29 September – 1 October 2025 | Karlsruhe, Germany</li><li><strong>Organizer:</strong> Gesellschaft Deutscher Chemiker (GDCh)</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/755">More information and registration at this link</a></li></ul><h5><strong>International Symposium on Preparative and Process Chromatography (PREP) 2025</strong></h5><ul><li>29 September – 2 October 2025 | Philadelphia, PA, USA</li><li><strong>Organizer: </strong>LD Organisation srl</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/899">More information and registration at this link</a></li></ul><h5><strong>SFC Europe 2025</strong></h5><ul><li>5–7 October 2025 | Basel, Switzerland</li><li><strong>Organizer:</strong> Green Chemistry Group</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/887">More information and registration at this link</a></li></ul><h5><strong>SciX 2025</strong></h5><ul><li>5–10 October 2025 | Covington, KY, USA</li><li><strong>Organizer</strong>: The Federation of Analytical Chemistry and Spectroscopy Societies (FACSS)</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/796">More information and registration at this link</a></li></ul><h5><strong>Innovate Pharma Summit</strong></h5><ul><li>7–8 October 2025 | Online</li><li><strong>Organizer: </strong>Technology Networks</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/918">More information and registration at this link</a></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Technology_Networks_Innovate_Pharma_Summit_2_9ccfe6ed04.jpg" alt="Technology Networks: Innovate Pharma Summit" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Technology_Networks_Innovate_Pharma_Summit_2_9ccfe6ed04.jpg 245w," sizes="100vw" width="640" height="360"></p><h5><strong>Shimadzu SFC User Meeting 2025</strong></h5><ul><li>8 October 2025 | Basel, Switzerland</li><li><strong>Organizer: </strong>Shimadzu Corporation</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/900">More information and registration at this link</a></li></ul><h5><strong>ASMS – 39th Asilomar Conference on Mass Spectrometry</strong></h5><ul><li>10–15 October 2025 | Monterey, CA, USA</li><li><strong>Organizer: </strong>ASMS</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/747">More information and registration at this link</a></li></ul><h5><strong>Gulf Coast Conference (GCC) 2025</strong></h5><ul><li>14–15 October 2025 | Galveston, Texas, USA</li><li><strong>Organizer: </strong>Gulf Coast Conference</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/905">More information and registration at this link</a></li></ul><h5><strong>Waters European Biopharma Analytical Forum</strong></h5><ul><li>15–16 October 2025 | Seville, Spain</li><li><strong>Organizer: </strong>Waters Corporation</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/917">More information and registration at this link</a></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Corporation_Waters_European_Biopharma_Analytical_Forum_ec382a082e.jpg" alt="Waters Corporation: Waters European Biopharma Analytical Forum" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Corporation_Waters_European_Biopharma_Analytical_Forum_ec382a082e.jpg 245w," sizes="100vw" width="1534" height="900"></p><h5><strong>Course: HPLC Method Development</strong></h5><ul><li>15–16 October 2025 | Online</li><li><strong>Organizer:</strong> Phenomenex</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/738">More information and registration at this link</a></li></ul><h5><strong>Live from the Lab: Solutions for Environmental and Food Contaminant Testing</strong></h5><ul><li>16–23 October 2025 | Europe / North America / Online</li><li><strong>Organizer:</strong> Thermo Fisher Scientific</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/920">More information and registration at this link</a></li></ul><h5><strong>SOFT 2025</strong></h5><ul><li>26–31 October 2025 | Portland, OR, USA</li><li><strong>Organizer: </strong>Society of Forensic Toxicologists</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/767">More information and registration at this link</a></li></ul><h5><strong>Course: An Introduction to LC-MS</strong></h5><ul><li>27–28 October 2025 | Online</li><li><strong>Organizer</strong>: Phenomenex</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/734">More information and registration at this link</a></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Phenomenex_Training_Courses_2025_c4712b0acc.jpg" alt="Phenomenex: Phenomenex Training Courses 2025" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Phenomenex_Training_Courses_2025_c4712b0acc.jpg 245w," sizes="100vw" width="1539" height="907"></p><h5><strong>ASMS – 36th Fall Workshop</strong></h5><ul><li>3–4 November 2025 | Seattle, WA, USA</li><li><strong>Organizer</strong>: ASMS</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/746">More information and registration at this link</a></li></ul><h5><strong>The International Doctoral Conference on Advances in Chemistry (IDCAC 2025)</strong></h5><ul><li>7–8 November 2025 | University of Chemistry and Technology, Prague</li><li><strong>Organizer: </strong>UCT Prague</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/911">More information and registration at this link</a></li></ul><h5><strong>AAPS 2025 PHARMSCI 360</strong></h5><ul><li>9–12 November 2025 | San Antonio, TX, USA</li><li><strong>Organizer: </strong>AAPS</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/753">More information and registration at this link</a></li></ul><h5><strong>24th Human Proteome Organization World Congress (HUPO) 2025</strong></h5><ul><li>9–13 November 2025 | Toronto, Canada</li><li><strong>Organizer: </strong>HUPO</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/732">More information and registration at this link</a></li></ul><h5><strong>PEGS Europe 2025</strong></h5><ul><li>11–13 November 2025 | Lisbon, Portugal</li><li><strong>Organizer: </strong>Cambridge Healthtech Institute</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/901">More information and registration at this link</a></li></ul><h5><strong>SETAC North America 46th Annual Meeting</strong></h5><ul><li>16–20 November 2025 | Portland, Oregon, USA</li><li><strong>Organizer:</strong> SETAC</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/754">More information and registration at this link</a></li></ul><h5><strong>Eastern Analytical Symposium (EAS) 2025</strong></h5><ul><li>17–19 November 2025 | Plainsboro, NJ, USA</li><li><strong>Organizer: </strong>Eastern Analytical Symposium and Exposition</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/902">More information and registration at this link</a></li></ul><h5><strong>Course: Troubleshoot HPLC – Identifying, Solving and Avoiding Problems</strong></h5><ul><li>18–19 November 2025 | Online</li><li><strong>Organizer:</strong> Phenomenex</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/740">More information and registration at this link</a></li></ul><h5><strong>Invited Lecture – Jana Roithová</strong></h5><ul><li>18 November 2025 | IOCB Prague</li><li><strong>Organizer: </strong>IOCB Prague</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/709">More information and registration at this link</a></li></ul><h5><strong>TIAFT 2025</strong></h5><ul><li>23–27 November 2025 | Auckland, New Zealand</li><li><strong>Organizer: </strong>The International Association of Forensic Toxicologists</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/768">More information and registration at this link</a></li></ul><h5><strong>Sample Preparation Seminar</strong></h5><ul><li>2–3 December 2025 | Online</li><li><strong>Organizer:</strong> Phenomenex</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/742">More information and registration at this link</a></li></ul>

Global LCMS Conferences and Training 2025 – LabRulez

<p><strong>At MSACL 2025, a Thermo Fisher Scientific–sponsored workshop led by Qin Fu addressed one of the most persistent challenges in proteomics: how to efficiently and reproducibly translate biomarker discoveries into clinically meaningful assays. Drawing on experience spanning academia and industry—including prior work in Jennifer Van Eyk’s lab—Fu shared practical insights into building a scalable, end-to-end biomarker discovery-to-validation pipeline.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Accelerating_Biomarker_Discovery_and_Validation_From_Discovery_to_Clinical_Utility_9558364cf2.jpg" alt="Thermo Fisher Scientific: Accelerating Biomarker Discovery and Validation: From Discovery to Clinical Utility" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Accelerating_Biomarker_Discovery_and_Validation_From_Discovery_to_Clinical_Utility_9558364cf2.jpg 245w," sizes="100vw" width="1024" height="512"></p><p>The session highlighted how emerging mass spectrometry technologies, automation, and informatics are reshaping biomarker research—reducing complexity, improving reproducibility, and accelerating the path to clinical utility.</p><h3><strong>The three tiers of biomarker assays</strong></h3><p>The workshop opened with a review of the widely accepted three-tier framework that guides biomarker development from early discovery through clinical validation:</p><h4><strong>Tier 3 – discovery</strong></h4><p>Exploratory, untargeted workflows such as data-dependent acquisition (DDA) and data-independent acquisition (DIA). These approaches prioritize breadth, enabling the identification of large-magnitude biological changes across hundreds to thousands of analytes, typically with low-to-moderate precision and without internal standards.</p><h4><strong>Tier 2 – verification</strong></h4><p>Research-grade targeted assays, including parallel reaction monitoring (PRM) and multiple reaction monitoring (MRM). These methods focus on tens to hundreds of analytes, delivering improved precision and repeatability to confirm trends observed during discovery.</p><h4><strong>Tier 1 – validation</strong></h4><p>Clinically validated assays designed to meet rigorous quality and regulatory standards. These workflows incorporate internal standards and strict quality controls to ensure quantitative reproducibility suitable for clinical and translational use.</p><p>Each tier represents a critical step toward ensuring that biomarker candidates can ultimately deliver reliable patient benefit.</p><h3><strong>The central challenge: from sample to signal</strong></h3><p>Reliable biomarker development depends on consistency across the entire analytical workflow—from biological sample preparation to mass spectrometry data acquisition and downstream analysis. Every step introduces potential sources of variability, and minimizing this analytical noise while preserving biological signal is essential.</p><p>Automation emerged as a central theme of the workshop. Beyond improving throughput, automation fundamentally enhances reproducibility. Robotic sample preparation reduces variability associated with digestion, pipetting, and handling—enabling consistent performance across hundreds or thousands of samples, a scale that is difficult to achieve manually.</p><h3><strong>Technological innovation powering a paradigm shift</strong></h3><p>Recent advances in mass spectrometry are enabling researchers to bridge the gap between discovery and validation more efficiently than ever before. The workshop highlighted several Thermo Fisher Scientific platforms driving this shift:</p><ul><li><strong>Thermo Scientific Orbitrap Astral mass spectrometer</strong><br>Optimized for discovery workflows, the Astral system delivers rapid acquisition and deep proteome coverage while maintaining high precision across large cohorts.</li><li><strong>Thermo Scientific Stellar platform</strong><br>Designed for high-throughput targeted quantification, the Stellar platform supports scalable PRM workflows. Features such as PRM Conductor enable adaptive retention time tracking, which is essential for robust performance in large studies.</li><li><strong>Thermo Scientific OptaSpray Ion Source (under evaluation)</strong><br>A hands-free ionization source designed to deliver consistent spray performance with simplified maintenance, supporting reproducibility across thousands of injections.</li></ul><p>Together, these technologies create a smoother continuum across assay tiers, shortening timelines and reducing barriers to clinical translation.</p><h3><strong>Case study: Inflammatory bowel disease (IBD) cohort</strong></h3><p>A key highlight of the presentation was a large-scale biomarker study in inflammatory bowel disease (IBD). The team conducted a 500-sample discovery analysis, followed by validation in a 1,000-sample cohort. Discovery was performed using the Orbitrap Astral system, while targeted validation employed the Stellar platform.</p><p>This integrated approach successfully confirmed established biomarkers such as C-reactive protein (CRP) while also identifying novel protein candidates with strong translational potential. Importantly, these markers demonstrated consistency across discovery and validation data sets—underscoring the power of advanced instrumentation combined with robust workflows and informatics.</p><h3><strong>From high quantity to high quality</strong></h3><p>Historically, biomarker discovery has involved a tradeoff between throughput and data quality. The workshop demonstrated that this compromise is no longer necessary. By integrating automated sample preparation, optimized informatics, and next-generation mass spectrometry, researchers can now generate high-quality, high-throughput data that is both scalable and reproducible.</p><p>This shift enables faster discovery while increasing confidence that candidate biomarkers are ready for downstream validation and clinical follow-up.</p><h3><strong>The future of biomarker translation</strong></h3><p>The workshop concluded on an optimistic note. Innovations in proteomics are fundamentally transforming biomarker development—shortening timelines, reducing costs, and accelerating the transition from discovery to clinical application.</p><p>By integrating platforms such as Orbitrap Astral, Stellar, and OptaSpray, Thermo Fisher Scientific is helping advance a new era of translational biomarker science—where precision, scalability, and reliability work together to deliver meaningful clinical impact.</p><p><i>Watch the full workshop recording to </i><a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/watch?v=ziyffQzZTwk"><i>explore the data, workflows, and results behind this end-to-end approach to biomarker discovery and validation.</i></a></p><h3><strong>Intended use disclaimer</strong></h3><p>General Laboratory Equipment – Not For Diagnostic Procedures.<br>Thermo Scientific general laboratory equipment, consumables, and software are intended for research, academic, and industrial use only. These products are not designed, validated, or approved for in vitro diagnostic or clinical use. Use of these products for diagnostic purposes may result in inaccurate results and potential health and safety risks.</p><h3><strong>Resources</strong></h3><p><strong>Workshop &amp; educational content</strong></p><ul><li>MSACL 2025 workshop recording: <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/watch?v=ziyffQzZTwk"><i><strong>Accelerating Biomarker Discovery and Validation</strong></i></a></li><li>Other MSACL workshop recordings <i>coming soon</i></li></ul><p><strong>Thermo Fisher Scientific Product Pages</strong></p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2207"><strong>Thermo Scientific TSQ Certis Mass Spectrometer</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/836"><strong>Thermo Scientific Orbitrap Astral Mass Spectrometer</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1149"><strong>Thermo Scientific Stellar Mass Spectrometer</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/order/catalog/product/B51004132">Thermo Scientific OptaSpray Ion Source</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/content/lifetech/global/en/home/industrial/mass-spectrometry/mass-spectrometer-price-affordability-programs.html">Mass spectrometer affordability programs</a> (Refurbished MS, trade-in, financing/ leasing)</li></ul><p><strong>Peer-Reviewed Literature</strong></p><ul><li>Baker ES et al. <a target="_blank" rel="noopener noreferrer" href="https://europepmc.org/article/MED/22943415"><i>Mass spectrometry for translational proteomics: progress and clinical implications.</i></a> Genome Medicine (2012).</li><li>Fu Q et al. <a target="_blank" rel="noopener noreferrer" href="https://academic.oup.com/clinchem/article/62/1/198/5611803"><i>An Empirical Approach to Signature Peptide Choice for Selected Reaction Monitoring.</i></a> Clinical Chemistry (2016).</li><li>Fu Q et al. <a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1002/mas.21750"><i>Automated proteomic sample preparation: The key component for high throughput and quantitative mass spectrometry analysis.</i></a> Mass Spectrometry Reviews (2023).</li><li>Fu Q et al. <a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1021/acs.jproteome.7b00623"><i>Highly Reproducible Automated Proteomics Sample Preparation Workflow for Quantitative Mass Spectrometry.</i></a> Journal of Proteome Research (2018).</li><li>Fu Q et al. <a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1002/anie.202409446"><i>A Proteomics Pipeline for Generating Clinical Grade Biomarker Candidates from DIA-MS Discovery.</i></a> Angewandte Chemie International Edition (2024).</li><li>Fu Q et al. <a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1002/anie.202507610"><i>Development and Clinical Evaluation of a Multiplexed Health Surveillance Panel Using Ultra High-Throughput PRM-MS in an Inflammatory Bowel Disease Cohort.</i></a> Angewandte Chemie International Edition (2025).</li></ul><blockquote><p><strong>Visit us on&nbsp;</strong><a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/"><strong><u>LinkedIn:</u></strong></a><strong>&nbsp;</strong>#Omics #BiomarkerDiscovery #MassSpectrometry #ClinicalResearch</p></blockquote>

Accelerating Biomarker Discovery and Validation: From Discovery to Clinical Utility

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