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<p><strong>You will be joining the dynamic Lipidomics Group at the University of Pardubice, working on high-impact research funded by prestigious grants:</strong></p><ol><li><strong>ERC Advanced grant “Oncolipidomics:</strong> Why is lipidomic dysregulation pattern in blood similar for various cancers? (ONCOLIPID)”</li><li><strong>OP JAK grant “Saving lives through research in early cancer detection and prevention:</strong> Molecular, genomic and societal factors (SALVAGE)”</li></ol><h3><strong>Two Postdoctoral Positions in Lipidomics and Glycomics</strong></h3><ul><li><strong>Start Date:</strong> January 2025 (or as soon as possible)</li><li><strong>Duration:</strong> 12 months, with a possibility of extension until the end of the project<br>(August 2028)</li><li><strong>Location:</strong> Lipidomics Group of Prof. Michal Holčapek, University of Pardubice, Faculty of Chemical Technology, Department of Analytical Chemistry, Czech Republic</li><li><strong>Salary:</strong> Competitive, based on university guidelines, and commensurate with experience and skills.</li></ul><h3><strong>1. Lipidomics Postdoc</strong></h3><p>You will be involved in the complete lipidomic analysis workflow, including:</p><ul><li>Sample preparation using established extraction protocols.</li><li>Ultrahigh-performance liquid chromatography - mass spectrometry (UHPLC/MS).</li><li>Data processing using LipidQuant software.</li><li>Advanced statistical evaluation using multivariate analysis tools (e.g., Simca, R-scripts).</li></ul><p>This role offers hands-on experience with state-of-the-art instrumentation and in-depth exposure to lipidomics applied to cancer biomarker discovery.</p><h3><strong>2. Glycomics Postdoc</strong></h3><p>You will focus on the glycomic analysis of glycans enzymatically released from glycosphingolipids, including:</p><ul><li>Sample preparation including enzymatic cleavage of glycans.</li><li>UHPLC/MS.</li><li>Identification of glycan sequences from MS/MS spectra, retention behavior, and ion mobility data, and quantitation.</li><li>Advanced statistical evaluation using multivariate analysis tools (e.g., Simca, R-scripts).</li></ul><p>This position offers the opportunity to innovate in data processing workflows and contribute to cutting-edge glycomics research.</p><h4>Requirements for Both Positions</h4><ul><li><strong>Ph.D.</strong> in (bio)analytical chemistry or a closely related field.</li><li>Proficiency in <strong>mass spectrometry</strong> and <strong>liquid chromatography</strong>.</li><li>Strong passion for scientific research, reliability, and the ability to work collaboratively in a dynamic team.</li></ul><h4><strong>Preferred but not required:</strong></h4><ul><li>Experience in <strong>lipidomic, metabolomic, or glycomic analysis</strong>.</li><li>Familiarity with <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?instrumentationItems=38"><strong>supercritical fluid chromatography-mass spectrometry</strong></a>.</li><li>Experience with <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=8&amp;search=TIMS-TOF"><strong>TIMS-TOF (Bruker)</strong></a><strong>, </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?instrumentationItems=29-31-30-32&amp;mainauthorItems=5"><strong>QTOF (Waters)</strong></a>, or <strong>QQQ (</strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?instrumentationItems=35-32-31&amp;mainauthorItems=55"><strong>Sciex</strong></a><strong>, </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?instrumentationItems=35-32-31&amp;mainauthorItems=10"><strong>Agilent</strong></a><strong>)</strong> instruments.</li><li>Knowledge of software tools for metabolomics/lipidomics (e.g., MZmine, Skyline).</li></ul><h4><strong>About the Lipidomics Research Group</strong></h4><p>Our group is an international, collaborative team of over 15 postdoctoral researchers and students. We offer a supportive and intellectually stimulating environment, with access to cutting-edge technology. We specialize in lipidomics and metabolomics by mass spectrometry, focusing on cancer biomarker discovery. Our <strong>patented methodology</strong> for the early detection of <strong>pancreatic</strong> and <strong>other cancers</strong> is currently being translated into clinical applications through our spin-off company, <a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/articles?search=Lipidica"><strong>Lipidica</strong></a>.&nbsp;</p><p>We provide comprehensive training in lipidomic techniques to all new members, including hands-on experience with the latest instruments and software.</p><h4><strong>Our Research Facilities</strong></h4><ul><li><strong>Mass Spectrometers:</strong> timsTOF Ultra (Bruker), QTOF Synapt G2Si (Waters), QTOF Xevo G2-XS (Waters), QTOF micrOTOF-QII (Bruker), MALDI LTQ Orbitrap XL (Thermo), 6500 QTRAP (Sciex), QqQ 6495D (Agilent), and Xevo TQD (Waters).</li><li><strong>Chromatographs:</strong> 2x ultrahigh-performance supercritical fluid chromatograph Waters ACQUITY UPC2 system (Waters), ACQUITY Premier UPLC Bioinert System (Waters), 2x UHPLC Agilent 1290 Infinity series (Agilent), and UHPLC Agilent 1290 Infinity II Bio (Agilent).</li><li><strong>Laboratory Equipment:</strong> Microbiological Safety Cabinet Mars Class II (LaboGene), Microbiological Safety Cabinet Class II MSC-Advantage™ Class II (ThermoFisher), Lab freezers (Arctiko and ThermoFisher), Homogenizer Combo Precellys Evolution + Cryolys Evolution (Bertin), etc.</li><li><strong>Data Processing Software:</strong> MarkerLynx (Waters), LipidQuant (our software), LipidView (Sciex), Simca (Umetrics), MetaboScape and TASQ ® Software (Bruker), etc.</li></ul><h4><strong>How to Apply</strong></h4><p>If you are enthusiastic about joining a world-class research team, please send the following documents:</p><p>1. <strong>A motivation letter</strong> detailing your research interests and why you want to join our group.</p><p>2. <strong>Your CV</strong>, including a description of your skills and relevant experience.</p><p>Candidates with strong experimental skills in mass spectrometry and chromatography will be prioritized. Shortlisted candidates will be invited to a Zoom interview.&nbsp;</p><p><strong>Note:</strong> The position remains open until filled. Early applications are encouraged.</p><p><a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/articles?search=Michal+Hol%C4%8Dapek"><strong>Prof. Michal Holčapek, Ph.D.</strong></a></p><p><strong>University of Pardubice</strong><br>Faculty of Chemical Technology, Department of Analytical Chemistry<br>Studentska 573, 53210 Pardubice, Czech Republic<br>Phone: +420 466 037 087<br>Email: <a href="mailto:Michal.Holcapek@upce.cz">Michal.Holcapek@upce.cz</a><br><a target="_blank" rel="noopener noreferrer" href="http://holcapek.upce.cz/">http://holcapek.upce.cz/</a></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/application::article.article/Univerzita-Pardubice-Michal-Holcapek.jpg" alt="Univerzita Pardubice: Prof. Michal Holčapek, Ph.D." width="null" height="null"></p>

Postdoctoral Positions in Lipidomics and Glycomics

<p><strong>As the world leader in serving science, our work is more than something that fills our days – what we do has great purpose. Our industry-leading scale means unparalleled commercial reach, unique customer access and a global footprint. Our broad customer base, from research to clinical to commercial production means you can have a broad and meaningful impact here at Thermo Fisher Scientific. All while working in an environment where you will be supported, valued and rewarded for your performance.</strong></p><h3><strong>Scientist III - HPLC, UPLC</strong></h3><div><div><div><div>At Thermo Fisher Scientific, you’ll discover meaningful work that makes a positive impact on a global scale. Join our colleagues in bringing our Mission to life - enabling our customers to make the world healthier, cleaner and safer. We provide our teams with the resources needed to achieve individual career goals while taking science a step beyond through research, development and delivery of life-changing therapies. With clinical trials conducted in 100+ countries and ongoing development of novel frameworks for clinical research through our PPD clinical research portfolio, our work spans laboratory, digital and decentralized clinical trial services. Your determination to deliver quality and accuracy will improve health outcomes that people and communities depend on – now and in the future.</div><div><div><div><div><div><p>Our PPD® Laboratory Services team has a direct impact on improving patient health through the expertise of scientists, industry thought-leaders and therapeutic experts. As the world leader in serving science, our laboratory professionals bring their commitment to accuracy and quality to deliver groundbreaking innovations!</p><h4><strong>Discover Impactful Work:</strong></h4><p>The Scientist role involves conducting analysis with a thorough understanding of laboratory procedures and increasing independence. This includes performing intricate sample preparation and analysis to quantitatively measure pharmaceutical and biopharmaceutical compounds across various formulations and biological matrices. The Scientist follows validated or experimental analytical procedures with occasional direct supervision, reviews and compiles results, and compares data against SOP acceptance criteria, methodologies, protocols, and product specifications. Additionally, the role requires entering data into databases and reports, as well as performing self-review of data prior to QC submission.</p><h4><strong>A Day in the Life:</strong></h4><ul><li>Performs a variety of sample preparation and analysis procedures to quantitatively measure pharmaceutical and biopharmaceutical compounds in a variety of formulations and /or biological matrices for stability and analytical testing.</li><li>Works with multiple functional groups to meet business needs.</li><li>Plans and organizes work with periodic supervision.</li><li>Sets up and maintains analytical instrumentation.</li><li>Trains on routine operation, maintenance and theory of analytical instrumentation, SOPs and regulatory procedures and guidelines.</li><li>Ensures QA findings are addressed appropriately.</li><li>Aids and training to other team members.</li><li>Problem solving, either independently or with assistance pertaining to extraction and/or instrumentation problems.</li><li>Communicates project status to project leader.</li><li>Performs work assignments accurately, and in a timely and safe manner.</li><li>Reviews, interprets, and analyzes data for technical, quality and compliance to protocols, methods, SOPs, client criteria and Good Manufacturing Practices (GMP) or Good Laboratory Practices (GLP).</li><li>Performs self and peer review of the data for accuracy and compliance with reporting requirements prior to submission to QA and issuance to customers.</li></ul><h3><strong>Keys to Success:</strong></h3><h4><strong>Education</strong></h4><ul><li>Bachelor's degree or equivalent and relevant formal academic / vocational qualification</li></ul><h4><strong>Experience</strong></h4><ul><li>Previous experience that provides the knowledge, skills, and abilities to perform the job (comparable to 5+ years).</li></ul><p><i>In some cases, an equivalency, consisting of a combination of appropriate education, training and/or directly related experience, will be considered sufficient for an individual to meet the requirements of the role.</i></p><h4><strong>Knowledge, Skills, Abilities</strong></h4><ul><li>Previous experience with HPLC and UPLC</li><li>Previous ELISA experience preferred</li><li>Proficient in Microsoft Excel and Word</li><li>Ability to independently optimize analytical methods</li><li>Problem solving and troubleshooting abilities</li><li>Good written and oral communication skills</li><li>Time management and project management skills</li><li>Ability to work in a collaborative work environment with a team</li></ul><h4><span><strong>Benefits</strong></span></h4><p>Thermo Fisher Scientific offers employment with an innovative, forward-thinking organization, and career and development prospects. We offer an exciting company culture that stands for integrity, intensity, involvement, and innovation!</p><p>We provide comprehensive benefits including comprehensive training, annual incentive plan bonus, medical, dental, vision, pharmacy, employee assistance program, wellness program options and more!</p><h4><strong>Other benefits include:</strong></h4><ul><li>401k with matching contributions, life insurance, long term and short term disability insurance, flexible medical and dependent care spending accounts.</li><li>Work life balance programs including paid time off for vacation/sick time, paid holidays, floating holiday.</li><li>Wellness benefits including health and wellness programs, fitness facility access or discount, health coaching and more.</li></ul><h4><strong>Work Environment</strong></h4><p>Thermo Fisher Scientific values the health and wellbeing of our employees. We support and encourage individuals to create a healthy and balanced environment where they can thrive. Below is listed the <span>working&nbsp;environment/requirements&nbsp;for</span> this role:</p><ul><li>Able to communicate, receive, and understand information and ideas with diverse groups of people in a comprehensible and reasonable manner.</li><li>Able to work upright and stationary and/or standing for typical working hours.</li><li>Able to lift and move objects up to 25 pounds.</li><li>Able to work in non-traditional work environments.</li><li>Able to use and learn standard office equipment and technology with proficiency.</li><li>May have exposure to potentially hazardous elements, including infectious agents, typically found in healthcare or laboratory environments.</li><li>Able to perform successfully under pressure while prioritizing and handling multiple projects or activities.</li></ul><p>Our Mission is to enable our customers to make the world healthier, cleaner and safer. Watch as our colleagues explain 5 reasons to work with us. As one team of 100,000+ colleagues, we share a common set of values - Integrity, Intensity, Innovation and Involvement - working together to accelerate research, solve complex scientific challenges, drive technological innovation and support patients in need. #StartYourStory with PPD, part of Thermo Fisher Scientific, where diverse experiences, backgrounds and perspectives are valued.</p></div><p>Apply today! <a target="_blank" rel="noopener noreferrer" href="http://jobs.thermofisher.com/"><span>http://jobs.thermofisher.com</span></a></p><p>Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status.</p><h4><span><strong>Accessibility/Disability</strong></span><strong> Access</strong></h4><p>Job Seekers with a Disability: Thermo Fisher Scientific offers accessibility service for job seekers requiring accommodations in the job application process. For example, this may include individuals requiring assistance because of hearing, vision, mobility, or cognitive impairments. If you are a job seeker with a disability, or assisting a person with a disability, and require accessibility assistance or an accommodation to apply for one of our jobs, please submit a request by telephone at 1-855-471-2255*. Please include your contact information and specific details about your required accommodation to support you during the job application process.</p><p>*This telephone line is reserved solely for job seekers with disabilities requiring accessibility assistance or an accommodation in the job application process. Messages left for other purposes, such as not being able to get into the career website, following up on an application, or other non-disability related technical issues will not receive a response.</p></div></div></div></div></div></div></div><h4><strong>Work Schedule</strong></h4><ul><li>Standard (Mon-Fri)</li></ul><h4><strong>Environmental Conditions</strong></h4><ul><li><span>Adherence to all Good Manufacturing Practices (GMP) Safety Standards, Laboratory Setting, Office, Some degree of PPE (Personal Protective Equipment) required (safety glasses, gowning, gloves, lab coat, ear plugs etc.)</span></li></ul>

Scientist III - HPLC, UPLC

<p><strong>As the world leader in serving science, our work is more than something that fills our days – what we do has great purpose. Our industry-leading scale means unparalleled commercial reach, unique customer access and a global footprint. Our broad customer base, from research to clinical to commercial production means you can have a broad and meaningful impact here at Thermo Fisher Scientific. All while working in an environment where you will be supported, valued and rewarded for your performance.</strong></p><h3><strong>Senior Scientist - HPLC - QC</strong></h3><div><div><div><section><div><p>At Thermo Fisher Scientific, you’ll discover meaningful work that makes a positive impact on a global scale. Join our colleagues in bringing our Mission to life - enabling our customers to make the world healthier, cleaner and safer. We provide our teams with the resources needed to achieve individual career goals while taking science a step beyond through research, development and delivery of life-changing therapies. With clinical trials conducted in 100+ countries and ongoing development of novel frameworks for clinical research through our PPD clinical research portfolio, our work spans laboratory, digital and decentralized clinical trial services. Your determination to deliver quality and accuracy will improve health outcomes that people and communities depend on – now and in the future.</p><p>Thermo Fisher's clinical research business is a leading global contract research organization and world leader in serving science. We are passionate, deliberate, and driven by our mission – to enable our customers to make the world healthier, safer, and cleaner.</p><p>Within our Analytical Services team, we have a functional service provider solution, which is a unique partnership that allows our customers to leverage the experience of our staff, while allowing you, the employee, to gain direct experience working onsite at a pharmaceutical/ biopharmaceutical company, all while maintaining full-time benefits.</p><h4><strong>Key responsibilities:</strong></h4><ul><li><strong>HPLC experience is a MUST HAVE</strong></li><li><strong>Small Molecule exp is a MUST HAVE</strong></li><li>Perform laboratory activities to meet commitments on-time</li><li>Perform in-process, release, and stability testing following established methodology, procedures and SOPs</li><li>Maintain accurate testing records and adhere to cGMP/GDP expectations</li><li>Participate in planning, executing, or reviewing method validations and/or method transfers</li><li>Troubleshoot analytical methods when necessary</li><li>May lead OOT/OOS investigations, deviations, and identify corrective actions to prevent reoccurrence.</li><li>Perform other laboratory duties as assigned</li><li>Authors, reviews and approves data, SOPs, analytical methods, protocols and reports</li><li>Participates in compliance related teams working towards the goal of continuous improvement</li><li>Serve as CQC representative in cross-functional working teams or working with outside vendors to meet all laboratory needs</li></ul><h4><strong>Education and Experience:</strong></h4><ul><li>Bachelor's degree in lab sciences such as Chemistry, Biochemistry, Material Science, Immunology, Biology, Molecular Biology or similar</li><li><strong>Sr. Scientist:</strong> Previous experience that provides the knowledge, skills, and abilities to perform the job <strong>(comparable to 4+ years’)</strong></li><li>OR Masters degree and previous experience that provides the knowledge, skills, and abilities to perform the job <strong>(comparable to 2+ years’)</strong></li><li>OR <strong>PhD</strong></li></ul><p>In some cases, an equivalency, consisting of a combination of appropriate education, training and/or directly related experience, will be considered sufficient for an individual to meet the requirements of the role.</p><h4><strong>Knowledge, Skills and Abilities:</strong></h4><ul><li>Strong knowledge of cGMP in a pharmaceutical setting</li><li>Strong knowledge in analytical techniques in a QC/commercial setting (e.g. HPLC, dissolution, GC, KF, etc.), including method validation/transfer</li><li>Experience with both drug substance and drug product (oral solid dosage forms) testing</li><li>Attention to detail</li><li>Effective communication skills, both verbal and written</li></ul><h4><strong>Working Environment:</strong></h4><p>Below is listed the working environment/requirements for this role:</p><ul><li>Able to communicate, receive, and understand information and ideas with diverse groups of people in a comprehensible and reasonable manner.</li><li>Able to work upright and stationary and/or standing for typical working hours.</li><li>Able to lift and move objects up to 25 pounds</li><li>Able to work in non-traditional work environments.</li><li>Able to use and learn standard office equipment and technology with proficiency.</li><li>May have exposure to potentially hazardous elements, including infectious agents, typically found in healthcare or laboratory environments.</li><li>Able to perform successfully under pressure while prioritizing and handling multiple projects or activities.</li><li>As a condition of employment with Thermo Fisher/PPD, in this role, you must have received your Covid-19 vaccine and you must disclose proof of your vaccination status upon employment.</li></ul></div></section></div></div></div><h4><strong>Work Schedule</strong></h4><ul><li>First Shift (Days)</li></ul><h4><strong>Environmental Conditions</strong></h4><ul><li><span>Adherence to all Good Manufacturing Practices (GMP) Safety Standards</span></li></ul>

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