The International School on Mass Spectrometry (IntSMS)
The 2nd Course is devoted to ION MOBILITY MASS SPECTROMETRY Fundamentals, Advances, and Applications.
The school joins together participants from academia, public and private research centers and industry, and it is an useful occasion for allowing meeting of students and tutors coming from different countries and for creating new links and networking.
All those wishing to improve their knowledge and culture in mass spectrometry are kindly invited to attend IntSMS.
Important Dates
- Registration Starts: October 2023
- Registration Ends: June 15, 2024
- Receiving Payment Deadline: June 30, 2024
- Cancellation and Refund Deadline: July 15, 2024
Registration
- Registration fee: € 650,00
- REGISTRATION FORM
School outline
In the last decade, mass spectrometry has had an impressive development and diffusion in many branches of science.
The number of installed instruments and people approaching mass spectrometry, mainly young scientists, are growing year by year: they design and carry out experiments, and interpret the data.
Unfortunately, the widespread use of mass spectrometry is not accompanied by a corresponding spreading and reinforcing of its culture: teaching of MS in the Universities is generally quite poor and there are no many valid occasions to enforce own culture in this discipline.
Given this background, the International School on Mass Spectrometry (IntSMS) is a six day full immersion school aimed to give advanced and higher education in mass spectrometry to graduate, PhD, post-doc students, and all those working in different areas of science, ranging from physics, chemistry, biosciences, food, environment, omics sciences to medicine, interested to improve their knowledge and culture in mass spectrometry.
The school will be also useful for allowing meeting, creating new links and networking among scientists coming from different countries.
Ion Mobility Mass Spectrometry (IMMS): Fundamentals, Advances, and Applications
Ion mobility (IM) measurements have become an important technology in mass spectrometry that finds applications in many fields.
IMMS allows separation, characterization and differentiation of populations of ions according to their charge, shape, and size on a millisecond timescale. Thus it is possible to investigate shape and conformation of ions having the same chemical formula, not differentiable by high resolution mass spectrometry, such as protomers or folded and denaturated forms of a protein, or it can be used as an additional separation step, ....
The school is organized in:
Tutorial lectures: (60-120 mins) aimed at presenting theory, instrumentation and applications of ion mobility mass spectrometry given by an international team of lecturers;
Poster sessions: Participants are encouraged to present a poster on their own research activity. Posters will be exhibited during the full period of the school to give the opportunity to those attending the school to go through;
Selected flash orals: (10 mins each). Selected posters will be presented as flash oral communications to give participants the opportunity to present their work;
Exercises: with the active participation of students in solving some exercises on matters presented in the lectures;
Problem solving: in which participants present to the others and tutors problems encountered in their scientific activity receiving suggestions on how to try to solve them.
Topics
- Ion Mobility Mass Spectrometry: fundamentals & instrumentation
- Collision cross section (CCS)
- CCS calculations for structural analysis
- Higher-order structural analysis: IMS-SID-MS, IMS-IMS-MS, IMS-CIU-MS, and FT-IMS-MS
- Mixtures and discovery: proteomics, glycomics, lipidomics, & metabolomics
- Data analysis
- Computational strategies: molecular modeling, machine learning and artificial intelligence
- Structure and stability in solution: using gas-phase ions to characterize solution structures
- Applications in different fields: food, doping, etc.
- Commercial instrumentation
- Innovation in instrumentation and methodologies
IntSMS: The International School on Mass Spectrometry (IntSMS) - Erice (Sicily)
School program
Monday, September 9th
12:00 - 5:00 p.m. Shuttle transfer from the airports in Trapani and Palermo
6:00 p.m. Registration
6:30 p.m. Welcome address. Presentation of the school
7:00 p.m. Opening lecture: Mass spectrometry: state of the art and beyond
8:00 p.m. Welcome party
Tuesday, September 10th
Introduction to ion mobility: fundamentals, experimental cross sections, molecular simulations, and cross section calculations for structural analysis.
8:30 a.m. Hybrid Ion mobility spectrometry and mass spectrometry measurements (IMS-MS): background and introduction (examples of small ions, polymers, proteins, complexes)
10:00 a.m. Coffee break & poster session
10:30 a.m. IMS-MS fundamentals – measurement and theory: timescales, detection limits, dynamic range, efficiency, peak capacity, resolving power, experimental cross sections, best practices for reporting results.
12:00 p.m. Molecular modeling & cross section calculations and applications
1:00 p.m. End of session
1:15 p.m. Lunch
Commercial instrumentation: Drift tube-, T-wave-, trapping-, field-asymmetric-IMS
3:00 p.m. Drift-tube and traveling-wave based IMS-MS instrumentation and methods
4:30 p.m. Coffee break & poster session
5:30 Trapping IMS & FAIMS
7:00 p.m. End of session
8:00 p.m. Dinner
Wednesday, September 11th
Higher-order structural analysis: IMS-SID-MS, IMS-IMS-MS, IMS-CIU-MS, and FT-IMS-MS
8:30 a.m. Determining stoichiometries and structures of large protein complexes by MS-SID-IMS-MS techniques
10:15 a.m. Coffee break & poster session
11:00 a.m. Biological machines
12:45 p.m. End of session
1:00 p.m. Lunch
Mixtures and discovery: proteomics, glycomics, lipidomics, & metabolomics
3:00 p.m. Higher order LC-IMS-MS separations for complex mixture analysis: proteomics and glyco-proteomics
4:45 p.m. Coffee break & poster session
5:30 p.m. An introduction to lipidomics and metabolomics
6:30 p.m. Database searching and exercises
7:30 p.m. End of session
8:00 p.m. Dinner
9:15 p.m. Problem solving … and drinks
Thursday, September 12th
Computational strategies: molecular modeling, CCS calculations, machine learning and artificial intelligence
8:30 a.m. Database strategies: large datasets, machine learning, CCS predictions, Artificial Intelligence
10:15 a.m. Coffee break & poster session
11:00 a.m. Artificial intelligence in IMMS; machine learning based CCS prediction
12:45 p.m. End of session
1:00 p.m. Lunch
Excursion and gala dinner. Have fun!!
2:30 p.m. Excursion to Marsala and Selinunte: guided tour
8:30 p.m. Gala dinner
11:00 p.m. Go back to Erice
Friday, September 13th
Structure and stability in solution: using gas-phase ions to characterize solution structures
8:30 a.m. Using gas-phase ions to follow complex structural transitions in solution
10:15 a.m. Coffee break & poster session
11:00 a.m. Characterizing the physical properties of molecules in solution by IMS-MS: understanding reactivity and stability
12:45 p.m. End of session
1:00 p.m. Lunch
Short orals, currently available IMMS instrumentation
2:45 p.m. Short orals by students (OR1-OR5)
3:40 p.m. Coffee break & poster session
4:10 p.m. Short orals by students (OR6-OR10)
5:00 p.m. Workshop: currently available IMMS instrumentation, methods & applications
6:45 p.m. Award for the best short oral! & Award for the best poster!
7:00 p.m. End of session
8:00 p.m. Dinner
9:15 p.m. Students of the IntSMS 2024 leave their memorable mark!
Saturday, September 14th
Food/drug/Olympic testing applications
8:30 a.m. Ion mobility mass spectrometry and food
10:00 a.m. Coffee break & poster session
10:30 a.m. Ion mobility and doping
12:00 p.m. Meeting students-tutors
12:30 p.m. Concluding remarks and Arrivederci!
1:00 p.m. Shuttle bus to the airports in Trapani and Palermo
