PhD candidates (FT-ICR MS top-down with UV and IR lasers)

Laboratory of Structural Biology and Cell Signaling consists of a multidisciplinary team whose thematic focus is divided into two main directions. Structural biology group produces proteins by recombinant expression technologies and characterizes the protein or protein-ligand structures and their dynamics utilizing advanced mass spectrometric techniques. Cell signaling unit examines the linkages of cellular signaling to the metabolism of cancer cells using molecular biology and biochemistry methods. Through the collaboration of the two groups a unique research platform is formed, wherein the results obtained by the study of biological systems can also be verified and explained at the molecular level. Laboratory is located at the BIOCEV center in Vestec.

PhD candidates wanted

The Laboratory of Structural Biology and Cell Signaling is looking for PhD candidates (m/f/d) at the intersection of Biochemistry, Analytical chemistry and Structural biology. Our young and dynamic group based in the modern, well-equipped research centre BioCeV offers a PhD position from October 2024 – application deadline 30.4.2024!

The topic is focused on the development of structural mass spectrometry techniques

• H/D exchange,

• native MS,

• singlet oxygen labelling,

• chemical cross-linking, FT-ICR MS top-down with UV and IR lasers

and their implementation in the study of the dynamics of prion proteins, membrane transporters and prenyltransferases.

BioCeV: lab