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ACQUITY UPLC M-Class System with HDX Technology Integration of Hydrogen Deuterium Exchange with High Resolution MS QUANT IF Y CHANGES IN P ROT EIN CONFORMAT ION W IT H CONFIDENC E The Waters ® ACQUITY UPLC ® M-Class System with…
Key words
hdx, hdxuplc, uplcdeuterium, deuteriumenzymate, enzymateprotein, proteinacquity, acquitywaters, watersconformat, conformatclass, classexchange, exchangechanges, changessyst, systpegylated, pegylatedproceeds, proceedspepsin
LOCALIZED CONFORMATION ANALYSES OF MUTATED HUMAN IgG1 BY HYDROGEN DEUTERIUM EXCHANGE MASS SPECTROMETRY AND DIFFERENTIAL SCANNING CALORIMETRY Joomi Ahn 1, Xiaojun Lu2, Colette Quinn3, St John Skilton1, Ying Qing Yu1, and Jihong Wang2 1 Waters Corporation, 2 MedImmune, 3TA Instruments…
Key words
mutated, mutatedpeptide, peptidehdx, hdxdeuterium, deuteriumconformational, conformationaluptake, uptakedynamx, dynamxchanges, changesdeuteration, deuterationplgs, plgscontrol, controlmhp, mhpsite, siteuptakes, uptakesdeuterated
PROBING SITE-SPECIFIC INTERACTIONS BETWEEN EPIDERMAL GROWTH FACTOR RECEPTOR AND AN ADNECTIN USING HDX-ETD MS APPROACH Jing Fang1 , Asish Chakraborty1, Ying Qing Yu1, Hui Wei2, Jingjie Mo2, Daniel Cohen3, Dianlin Xie3, Zheng Lin3, Paul E. Morin3, Michael L. Doyle3, Adrienne…
Key words
hdx, hdxetd, etdegfr, egfradnectin, adnectinbinding, bindingbound, boundepidermal, epidermalsite, siteunbound, unboundreceptor, receptordeuterium, deuteriumspecific, specificpeptide, peptidetargeted, targeteddissociation
Conformational Characterization of Calmodulin by Hydrogen Deuterium Exchange Mass Spectrometry Joomi Ahn, Martha Stapels, Michael Eggertson, Keith Fadgen, and Ying Qing Yu Waters Corporation, Milford, MA, U.S. A P P L I C AT I O N B E N…
Key words
deuterium, deuteriumcalmodulin, calmodulinhdx, hdxconformational, conformationalapo, apoholo, holoexchange, exchangehydrogen, hydrogenprotein, proteinuptake, uptakepep, peppepsin, pepsinnanoacquity, nanoacquitycharacterization, characterizationconformation
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