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Coupling of GC and LCMS Systems via SICRIT Soft Ionization Source for Sensitive Detection of Nitrosamines

Applications | 2020 | ShimadzuInstrumentation
GC, GC/MSD, GC/MS/MS, GC/QQQ, LC/MS, LC/MS/MS, LC/QQQ
Industries
Pharma & Biopharma
Manufacturer
Shimadzu, Plasmion
Key words
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Application Note Sensitive Detection of Nitrosamines for Drug Quality Control using SICRIT® Soft Ionization-MS Summary In this study we demonstrate sensitive determination of nitrosamine compounds by GC-soft ionization-MS outperforming GC-MS and LC-MS methods in view of drug quality control. In…
Key words
sicrit, sicritnitrosamine, nitrosaminedrug, drugionization, ionizationreserved, reservedndma, ndmanitrosodimethylamine, nitrosodimethylaminerights, rightsnitrosamines, nitrosaminesimpurities, impuritiesmanufacturer‘s, manufacturer‘stemperature, temperaturediethylnitrosoamine, diethylnitrosoamineoutperforming, outperformingthere‘s
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Soft Ionization GC Coupling to LC-MS Systems Combine the best of both worlds – all advantages from GC and LC-MS in an integrated solution A Powerful Combination Instead of Separate Solutions GC-MS is the method of choice for many challenges…
Key words
sicrit, sicritcoupling, couplingionization, ionizationplasmion‘s, plasmion‘ssoft, softenables, enablessource, sourcespme, spmepal, palheated, heatedplasmion, plasmionconnection, connectiondiazinone, diazinonecold, coldrtc
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An Integrated Solution to Speed up Routine Analysis Maximize sample throughput while upholding rigor quantification Integrated Rather than Separated Solution The tedious sample preparation combined with the long analysis times make it very complex to handle the increasing volume of…
Key words
sicrit, sicritplasmion‘s, plasmion‘sspme, spmeenables, enablesworkflows, workflowsplasmion, plasmionpal, palnegative, negativeroutine, routinedirect, directsolution, solutionmodule, modulesource, sourceintegrated, integratedionization
Application Note No. 62 Analysis of Pharmaceuticals’ Impurity - Regulations and Analysis for Carcinogenic Substances Dheeraj Handique *a), Nitish Suryawanshi *a), Crystal Yeong *b), Cynthia Lahey *b), Shailendra Rane *a), Deepti Bhandarkar *a), Anant Lohar *a), Gao Jie san *c),…
Key words
ndma, ndmandea, ndeacarcinogenic, carcinogenicsubstances, substancesmutagenic, mutagenicmms, mmsems, emsimpurity, impuritymode, modeims, imsmutagenicity, mutagenicitydrug, drugolmesartan, olmesartanndba, ndbapharmaceuticals
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