Agilent LC & CE Drivers 3.4

Significance of LC & CE Drivers Release 3.4

LC & CE instrument drivers govern communication between analytical hardware and chromatography data systems. They are critical to ensure reliable data acquisition, precise instrument control, and seamless integration in routine and advanced workflows. The 3.4 release expands module support, future-proofs system functionality, and enhances stability across modern operating environments.

Objectives and Overview of Release 3.4

This update aims to:

• Integrate new Infinity II Bio pumps and Online Sample Manager modules.
• Introduce flow-adaptive fraction collection and enhanced cluster functionality.
• Prepare for 2D-LC system control and upcoming MassHunter/OpenLab CDS enhancements.
• Extend compatibility with ISET 4.3 and Windows Server 2016.

Methodology and Instrumentation

Driver development followed Agilent’s framework for instrument control and firmware compatibility. Extensive testing ensured:

• Support for Windows 8.1, 10, Server 2012 R2, 2016 (64 bit) environments.
• Interoperability with OpenLab CDS, ChemStation, MassHunter Acquisition for LC/TOF and Q-TOF.
• End-to-end compatibility with Infinity II Bio Flexible Pumps (G7131A/C), Online Sample Manager (G3167A), various fraction collectors, and 2D-LC system drivers.
• Firmware alignment with Agilent sets A–D (versions ≥ recommended minima).

Main Results and Discussion

Release 3.4 delivers:

• Full integration of new Bio pump modules (1290 and 1260 Infinity II).
• Support for the 1260 Infinity II Online Sample Manager and corresponding high-pressure valves.
• Dynamic flow gradients during fraction collection and improved fraction collector clusters.
• “Ready for data acquisition” 2D-LC system driver pending license activation and forthcoming CDS updates.
• Compatibility with ISET 4.3 enabling characterization of Infinity II modules.
• Validated operation on Windows Server 2016.

Benefits and Practical Applications

• Expanded hardware integration streamlines method development in proteomics, biochemistry, and preparative separations.
• Advanced fraction collection improves sample handling in automated workflows.
• 2D-LC readiness accelerates adoption of multidimensional separations for complex mixtures.
• Broader OS and CDS support ensures long-term stability in regulated and research laboratories.

Future Trends and Possibilities

Anticipated directions include licensed 2D-LC driver activation, deeper integration within MassHunter and OpenLab CDS platforms, enhanced cluster drivers for high-throughput campaigns, and continued firmware-driven improvements. Integration with emerging automation frameworks may further streamline complex workflows.

Conclusion

Driver version 3.4 significantly extends Agilent’s LC and CE control capabilities by incorporating new hardware modules, enhancing automation features, and ensuring compatibility with modern software environments. It lays the groundwork for advanced two-dimensional separations and future software enhancements.