Agilent LC & CE Drivers 3.5

Significance of the Topic

The Agilent LC & CE Drivers provide the essential software interface linking Agilent chromatography and capillary electrophoresis instruments to data systems. Reliable drivers ensure precise instrument control, data integrity, and seamless workflow integration, which are critical for analytical laboratories in research, quality assurance, and regulatory environments.

Objectives and Overview of the Release Note

This release note outlines version 3.5 of the Agilent LC & CE Drivers, focusing on newly introduced features, compatibility updates, installation and update procedures, and ongoing enhancements. It serves as a comprehensive guide for system administrators and analysts to plan, deploy, and maintain the driver software in various operational settings.

Instrumentation

Version 3.5 supports an extensive range of Agilent modules including:

• Pumps: 1100, 1200, 1260/1290 Infinity series and 1260/1290 Infinity II flexible and high-speed pumps
• Autosamplers and multisamplers: standard, preparative, micro-scale, bio-inert and vialsamplers
• Detectors: VWD, DAD, fluorescence, refractive index, evaporative light scattering (ELSD)
• Valves and valve drives: multi-port selector, micro, bio-inert, 2D-LC and ASM valves
• Column thermostats: single and multi-column compartments, integrated column oven
• Fraction collectors: analytical, preparative, micro-scale and open-bed systems
• Capillary electrophoresis: Agilent 7100 CE system with or without DAD

Compatibility extends to major data systems such as OpenLab CDS (2.5–2.7), ChemStation C.01.10/11, MassHunter Acquisition 11.0, and various instrument control frameworks (ICF). Supported operating systems include Windows 10/11 (64-bit) and Windows Server 2012 R2/2016.

Methodology and Release Process

The driver development follows a modular structure with rigorous compatibility testing against firmware revisions (A–D architectures) and host platforms. The release incorporates feedback from Software Status Bulletins (SSB) and Software Release Bulletins (SRB) to address defects, ensure robustness, and align with new module firmware requirements.

Main Results and Discussion

Key enhancements in version 3.5 include:

• Configurable user permissions to restrict context-menu access for non-admin operators, improving operational security
• Native support for the Thermal Equilibration Device (G7116A/B) for advanced temperature equilibration workflows
• Enhanced 2D-LC system driver enabling use of ASM valves without park decks
• Official support for 64-bit Windows 11 installations
• Removal of Russian language localization to streamline maintenance and focus on primary markets
• Continuous refinements to existing drivers for improved performance and stability

These results broaden hardware compatibility, bolster security, and simplify complex multi-dimensional chromatography setups.

Benefits and Practical Applications

The updated drivers empower laboratories to:

• Safeguard instrument configurations through role-based access control
• Integrate new hardware seamlessly, including emerging devices and thermal accessories
• Optimize 2D-LC and high-throughput workflows with flexible valve configurations
• Maintain compliance with evolving IT environments by supporting the latest OS versions

These capabilities enhance productivity, regulatory compliance, and data reliability across analytical platforms.

Future Trends and Possibilities

Looking ahead, driver development is expected to focus on:

• Extended support for cloud-enabled instrument management and remote diagnostics
• AI-driven monitoring and predictive maintenance features
• Integration with next-generation multi-omics and process analytics technologies
• Expanded platform interoperability with third-party and open-source data systems

Advances in automation and digitalization will further streamline laboratory operations and data workflows.

Conclusion

Agilent LC & CE Drivers 3.5 represent a significant step in enhancing instrument control security, broadening hardware and OS compatibility, and refining multi-dimensional chromatography functionalities. By following the detailed compatibility matrix and installation guidelines, laboratories can achieve reliable performance and leverage new device capabilities with confidence.

References

• Agilent Technologies. LC & CE Drivers 3.5 Release Note. Document Number D0011877, Rev A, 2021.
• Software Status Bulletin (SSB). Agilent Technologies.
• Software Release Bulletin (SRB). Agilent Technologies.