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Rapid Metabolite Tof Screening, Structure Elucidation and Clearance Estimates Using Informatics-HRMS Approaches

 

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Direct Detection of Glutathione Conjugates in Human Liver Microsomes Using ACQUITY UPLC I-Class, Xevo G2-S QTof, and UNIFI Yun W. Alelyunas, Mark D. Wrona, and Paul D. Rainville Waters Corporation, Milford, MA, USA A P P L I C AT…
Key words
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A P P LICAT ION SOLUT IONS FO R M ETABOLIT E IDENT IFICAT ION A P P L I C AT I O N S O L U T I O N S F O R M E TA…
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synapt, synaptuplc, uplcmetabolite, metabolitemetabolynx, metabolynxwaters, watersmassfragment, massfragmenthdms, hdmsdrug, drugmetabolites, metabolitesetabolite, etabolitedata, datafragment, fragmentgsh, gshvivo, vivoacquity
Effect of MS Scan Speed on UPLC Peak Separation and Metabolite Identification: Time-of-Flight HRMS vs. Orbitrap Yun W. Alelyunas, Mark D. Wrona, Kevin Cook, Stephen McDonald, Paul D. Rainville Waters Corporation, Milford, MA, USA A P P L I C…
Key words
metabolite, metaboliteglyburide, glyburidescanning, scanningscan, scanresolution, resolutionmetabolites, metabolitesmicrosomal, microsomalhrms, hrmsincubate, incubateuplc, uplcnegatives, negativesslower, slowerequally, equallyfast, fastspeeds
[ APPLICATION NOTE ] Metabolite Identification: Working with Large Preclinical Multispecies Data Sets Mark Wrona, 1 Sherri Naughton, 1 Yun Alelyunas, 1 Russell Mortishire-Smith, 2 and Jayne Kirk 2 1 Waters Corporation, Milford, MA, USA 2 Waters Corporation, Wilmslow, UK…
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mobility, mobilitymetabolite, metabolitevion, vionims, imshrms, hrmsmetabolites, metabolitesapplication, applicationnote, noteion, ionbiotransformation, biotransformationqtof, qtofpreclinical, preclinicaltools, toolsidentification, identificationdrug
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