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Effect of MS Scan Speed on UPLC Peak Separation and Metabolite Identification: Time-of-Flight HRMS vs. Orbitrap

 

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Direct Detection of Glutathione Conjugates in Human Liver Microsomes Using ACQUITY UPLC I-Class, Xevo G2-S QTof, and UNIFI Yun W. Alelyunas, Mark D. Wrona, and Paul D. Rainville Waters Corporation, Milford, MA, USA A P P L I C AT…
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Simultaneous in vivo Quantification and Metabolite Identification of Plasma Samples Using High Resolution QTof and Routine MS E Data Analysis Mark Wrona,1 Paul Rainville,1 Eric Langlois,2 Nigel Ewing,3 and Julie Laterreur2 1 Waters Corporation, Milford, MA, USA 2 Vertex Biopharmaceuticals,…
Key words
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Rapid Metabolite Tof Screening, Structure Elucidation and Clearance Estimates Using Informatics-HRMS Approaches AAPS Poster # W4297, Wednesday 9:30-12:30 Yun W. Alelyunas, Mark D. Wrona, and Paul Rainville Purpose: Phase I Examples Glyburide Waters Corporation, Milford, Massachusetts, USA Buspirone Verapamil Demonstrate…
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metabolites, metabolitesgsh, gshsubset, subsethrms, hrmsall, allmetabolite, metabolitecharged, chargedverapamil, verapamilspecies, specieswinnonlin, winnonlinacross, acrossdata, dataovertime, overtimeglyburide, glyburideplot
Quantitation by High Resolution Mass Spectrometry: Using Target Enhancement and Tof-MRM to Achieve Femtogram-level On-column Sensitivity for Quantitation of Drugs in Human Plasma Yun W. Alelyunas, Mark D. Wrona, Russell J. Mortishire-Smith, Nick Tomczyk, and Paul D. Rainville Waters Corporation,…
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mrm, mrmtof, tofclopidogrel, clopidogrelbuspirone, buspironemse, mseverapamil, verapamildev, devalprazolam, alprazolamplasma, plasmahrms, hrmsfemtogram, femtogramblank, blankuplc, uplcplatforms, platformsacquity
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