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Simultaneous in vivo Quantification and Metabolite Identification of Plasma Samples Using High Resolution QTof and Routine MSE Data Analysis

 

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Determination of Mass Resolution, Sensitivity, and Linear Dynamic Range of Small Molecules in Human Plasma Using ACQUITY UPLC I-Class and Xevo G2-S QTof Yun Alelyunas, Craig Dorschel, Mark Wrona, and Paul Rainville G OA L The sensitivity of the high…
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Effect of MS Scan Speed on UPLC Peak Separation and Metabolite Identification: Time-of-Flight HRMS vs. Orbitrap Yun W. Alelyunas, Mark D. Wrona, Kevin Cook, Stephen McDonald, Paul D. Rainville Waters Corporation, Milford, MA, USA A P P L I C…
Key words
metabolite, metaboliteglyburide, glyburidescanning, scanningscan, scanresolution, resolutionmetabolites, metabolitesmicrosomal, microsomalhrms, hrmsuplc, uplcincubate, incubatenegatives, negativesslower, slowerequally, equallyfast, fastspeeds
[ APPLICATION NOTE ] Metabolite Identification: Working with Large Preclinical Multispecies Data Sets Mark Wrona, 1 Sherri Naughton, 1 Yun Alelyunas, 1 Russell Mortishire-Smith, 2 and Jayne Kirk 2 1 Waters Corporation, Milford, MA, USA 2 Waters Corporation, Wilmslow, UK…
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mobility, mobilitymetabolite, metabolitevion, vionims, imsmetabolites, metaboliteshrms, hrmsapplication, applicationnote, noteion, ionqtof, qtofbiotransformation, biotransformationpreclinical, preclinicaltools, toolsidentification, identificationdrug
[ APPLICATION NOTEBOOK ] PEPTIDE AND PROTEIN BIOANALYSIS [ OUR SCIENTISTS ] Yun Alelyunas, PhD Before coming to Waters in 2012, Yun Alelyunas was a principal scientist and team leader at AstraZeneca for 20 years where she was involved in…
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