Intact Protein Analysis Using an Agilent 6550 Q-TOF Mass Spectrometer | LabRulez LCMS
 

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Precise Characterization of IntactMonoclonal Antibodies by theAgilent 6545XT AdvanceBio LC/Q-TOFApplication NoteAuthorIntroductionDavid L. WongMonoclonal antibodies (mAbs) are a very important class of biopharmaceuticalmolecules. As a protein drug, thorough characterization of the mAb is required in eachof the manufacturing steps. Intact mAb...
Key words
glcnac, glcnacintact, intactbioconfirm, bioconfirmdeconvoluted, deconvolutedmass, massdeconvolution, deconvolutionamu, amudar, darantibodies, antibodiesmab, mabglycoforms, glycoformscounts, countsmaxent, maxententropy, entropymonoclonal
Application NoteBiologicsEfficient Monoclonal Antibody andAntibody Drug Conjugate DesaltingPrior to Mass Spectrometry UsingAdvanceBio Desalting-RP CartridgesAuthorsIsabel Vandenheede,Pat Sandra, and Koen SandraResearch Institute forChromatography (RIC)President Kennedypark 26B-8500 KortrijkAnne Blackwell andMaureen JosephAgilent Technologies, Inc.2850 Centreville RdWilmington DE 19808USAAbstractThis Application Note describes the use of...
Key words
herceptin, herceptincounts, countsdesalting, desaltingpapain, papaindeconvoluted, deconvolutedamu, amuidez, idezadvancebio, advancebiomass, masscartridge, cartridgelinker, linkerdtt, dttdigested, digestedfab, fabmabs
Clone Selection Using theAgilent 1290 Infinity Online 2D-LC/MSSolutionApplication NoteBiopharmaceuticalsAuthorsAbstractRavindra Gudihal andThis Application Note describes the Agilent 1290 Infinity online 2D-LC/MSSyed Salman Lateefsolution and proof of principle for clone selection and quantification of monoclonalAgilent Technologies, India Pvt Ltd,antibody (mAb) using an...
Key words
counts, countsbiosimilar, biosimilarclone, clonedeconvoluted, deconvolutedamu, amumass, massinnovator, innovatoragilent, agilentcharge, chargepurification, purificationdesalting, desaltingrituximab, rituximabmin, minprotein, proteindimension
Analysis of Monoclonal Antibody(mAb) Using Agilent 1290 InfinityLC System Coupled to Agilent 6530Accurate-Mass QuadrupoleTime-of-Flight (Q-TOF)Application NoteAuthorsAbstractRavindra Gudihal and Suresh Babu CVThis Application Note describes the use of an Agilent 1290 Infinity LC SystemAgilent Technologies India pvt. Ltd.coupled to an Agilent...
Key words
deconvoluted, deconvolutedcounts, countsamu, amupmod, pmodmass, massdeconvolution, deconvolutionmab, mabintact, intactmodeling, modelingalgorithm, algorithmmabs, mabsmasshunter, masshuntervoltage, voltagebioconfirm, bioconfirmpeak
 

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Precise Characterization of IntactMonoclonal Antibodies by theAgilent 6545XT AdvanceBio LC/Q-TOFApplication NoteAuthorIntroductionDavid L. WongMonoclonal antibodies (mAbs) are a very important class of biopharmaceuticalmolecules. As a protein drug, thorough characterization of the mAb is required in eachof the manufacturing steps. Intact mAb...
Key words
glcnac, glcnacintact, intactbioconfirm, bioconfirmdeconvoluted, deconvolutedmass, massdeconvolution, deconvolutionamu, amudar, darantibodies, antibodiesmab, mabglycoforms, glycoformscounts, countsmaxent, maxententropy, entropymonoclonal
Application NoteBiologicsEfficient Monoclonal Antibody andAntibody Drug Conjugate DesaltingPrior to Mass Spectrometry UsingAdvanceBio Desalting-RP CartridgesAuthorsIsabel Vandenheede,Pat Sandra, and Koen SandraResearch Institute forChromatography (RIC)President Kennedypark 26B-8500 KortrijkAnne Blackwell andMaureen JosephAgilent Technologies, Inc.2850 Centreville RdWilmington DE 19808USAAbstractThis Application Note describes the use of...
Key words
herceptin, herceptincounts, countsdesalting, desaltingpapain, papaindeconvoluted, deconvolutedamu, amuidez, idezadvancebio, advancebiomass, masscartridge, cartridgelinker, linkerdtt, dttdigested, digestedfab, fabmabs
Clone Selection Using theAgilent 1290 Infinity Online 2D-LC/MSSolutionApplication NoteBiopharmaceuticalsAuthorsAbstractRavindra Gudihal andThis Application Note describes the Agilent 1290 Infinity online 2D-LC/MSSyed Salman Lateefsolution and proof of principle for clone selection and quantification of monoclonalAgilent Technologies, India Pvt Ltd,antibody (mAb) using an...
Key words
counts, countsbiosimilar, biosimilarclone, clonedeconvoluted, deconvolutedamu, amumass, massinnovator, innovatoragilent, agilentcharge, chargepurification, purificationdesalting, desaltingrituximab, rituximabmin, minprotein, proteindimension
Analysis of Monoclonal Antibody(mAb) Using Agilent 1290 InfinityLC System Coupled to Agilent 6530Accurate-Mass QuadrupoleTime-of-Flight (Q-TOF)Application NoteAuthorsAbstractRavindra Gudihal and Suresh Babu CVThis Application Note describes the use of an Agilent 1290 Infinity LC SystemAgilent Technologies India pvt. Ltd.coupled to an Agilent...
Key words
deconvoluted, deconvolutedcounts, countsamu, amupmod, pmodmass, massdeconvolution, deconvolutionmab, mabintact, intactmodeling, modelingalgorithm, algorithmmabs, mabsmasshunter, masshuntervoltage, voltagebioconfirm, bioconfirmpeak
 

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