Sensitive Native Mass Spectrometry of Macromolecules Using Standard Flow LC/MSApplications | 2020 | Agilent TechnologiesInstrumentation
LC/TOF, LC/HRMS, LC/MS, LC/MS/MS
Industries
Pharma & Biopharma
Manufacturer
Agilent Technologies
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Application NotePharma & BiopharmaMass Spectrometric Characterizationof Antibody-siRNA Conjugates usingthe Agilent 6545XT AdvanceBioLC/Q‑TOFAuthorDavid L. WongAgilent Technologies, Inc.AbstractSmall interfering RNAs (siRNAs) are a promising type of RNA-based therapeuticdrugs that demonstrate effectiveness on gene silencing through RNA interference(RNAi). However, due to the chemical...
Key words
sirna, sirnamab, mabconjugates, conjugatesintact, intactcounts, countsdeglycosylated, deglycosylatednative, nativedeconvoluted, deconvolutedamu, amuadvancebio, advancebiomass, massrna, rnaantibody, antibodysirnas, sirnaslinker
Precise Characterization of IntactMonoclonal Antibodies by theAgilent 6545XT AdvanceBio LC/Q-TOFApplication NoteAuthorIntroductionDavid L. WongMonoclonal antibodies (mAbs) are a very important class of biopharmaceuticalmolecules. As a protein drug, thorough characterization of the mAb is required in eachof the manufacturing steps. Intact mAb...
Key words
glcnac, glcnacintact, intactbioconfirm, bioconfirmdeconvoluted, deconvolutedmass, massdeconvolution, deconvolutionamu, amudar, darantibodies, antibodiesmab, mabglycoforms, glycoformscounts, countsmaxent, maxententropy, entropymonoclonal
Application NoteBiopharmaComprehensive Approachesto Higher-Order Structure ofIntact Proteins by Native MassSpectrometryAuthorsCaroline S. Chu,Patrick D. Perkins,Christian Klein, andAndrew GieschenAgilent Technologies, Inc.AbstractThis application note presents different approaches to native mass spectrometry(nMS) using Agilent high resolution mass spectrometers for analysis of intactproteins and noncovalent...
Key words
counts, countsmass, masscharge, chargenoncovalent, noncovalentnative, nativecomplexes, complexesdehydrogenase, dehydrogenasedesalting, desaltingcapillary, capillaryonline, onlinevoltage, voltageswarm, swarmgas, gasprotein, proteinmobility
Poster ReprintASMS 2020MP 499High Throughput Native MS WithRobust Ion Source Operation ForThe Analysis Of Proteins AndProtein ComplexesCaroline S. Chu, Patrick D. Perkins, ChristianKleinAgilent Technologies, Santa Clara, CA USA IntroductionNative mode proteins and protein complexes aretypically analyzed using nanospray techniques or atcapillary...
Key words
complexes, complexesnative, nativetetramer, tetramerprotein, proteinadh, adhparameter, parametersource, sourcestate, statecharge, chargeflow, flowproteins, proteinsion, ionklein, kleinvalue, valuesheath

Sensitive Native Mass Spectrometry of Macromolecules Using Standard Flow LC/MSApplications | 2020 | Agilent TechnologiesInstrumentation
LC/TOF, LC/HRMS, LC/MS, LC/MS/MS
Industries
Pharma & Biopharma
Manufacturer
Agilent Technologies
Key words

 

Similar PDF

Toggle
Application NotePharma & BiopharmaMass Spectrometric Characterizationof Antibody-siRNA Conjugates usingthe Agilent 6545XT AdvanceBioLC/Q‑TOFAuthorDavid L. WongAgilent Technologies, Inc.AbstractSmall interfering RNAs (siRNAs) are a promising type of RNA-based therapeuticdrugs that demonstrate effectiveness on gene silencing through RNA interference(RNAi). However, due to the chemical...
Key words
sirna, sirnamab, mabconjugates, conjugatesintact, intactcounts, countsdeglycosylated, deglycosylatednative, nativedeconvoluted, deconvolutedamu, amuadvancebio, advancebiomass, massrna, rnaantibody, antibodysirnas, sirnaslinker
Precise Characterization of IntactMonoclonal Antibodies by theAgilent 6545XT AdvanceBio LC/Q-TOFApplication NoteAuthorIntroductionDavid L. WongMonoclonal antibodies (mAbs) are a very important class of biopharmaceuticalmolecules. As a protein drug, thorough characterization of the mAb is required in eachof the manufacturing steps. Intact mAb...
Key words
glcnac, glcnacintact, intactbioconfirm, bioconfirmdeconvoluted, deconvolutedmass, massdeconvolution, deconvolutionamu, amudar, darantibodies, antibodiesmab, mabglycoforms, glycoformscounts, countsmaxent, maxententropy, entropymonoclonal
Application NoteBiopharmaComprehensive Approachesto Higher-Order Structure ofIntact Proteins by Native MassSpectrometryAuthorsCaroline S. Chu,Patrick D. Perkins,Christian Klein, andAndrew GieschenAgilent Technologies, Inc.AbstractThis application note presents different approaches to native mass spectrometry(nMS) using Agilent high resolution mass spectrometers for analysis of intactproteins and noncovalent...
Key words
counts, countsmass, masscharge, chargenoncovalent, noncovalentnative, nativecomplexes, complexesdehydrogenase, dehydrogenasedesalting, desaltingcapillary, capillaryonline, onlinevoltage, voltageswarm, swarmgas, gasprotein, proteinmobility
Poster ReprintASMS 2020MP 499High Throughput Native MS WithRobust Ion Source Operation ForThe Analysis Of Proteins AndProtein ComplexesCaroline S. Chu, Patrick D. Perkins, ChristianKleinAgilent Technologies, Santa Clara, CA USA IntroductionNative mode proteins and protein complexes aretypically analyzed using nanospray techniques or atcapillary...
Key words
complexes, complexesnative, nativetetramer, tetramerprotein, proteinadh, adhparameter, parametersource, sourcestate, statecharge, chargeflow, flowproteins, proteinsion, ionklein, kleinvalue, valuesheath
 

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