Sensitive Native Mass Spectrometry of Macromolecules Using Standard Flow LC/MS | LabRulez LCMS
 

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Application NotePharma & BiopharmaMass Spectrometric Characterizationof Antibody-siRNA Conjugates usingthe Agilent 6545XT AdvanceBioLC/Q‑TOFAuthorDavid L. WongAgilent Technologies, Inc.AbstractSmall interfering RNAs (siRNAs) are a promising type of RNA-based therapeuticdrugs that demonstrate effectiveness on gene silencing through RNA interference(RNAi). However, due to the chemical...
Key words
sirna, sirnamab, mabconjugates, conjugatesintact, intactcounts, countsdeglycosylated, deglycosylateddeconvoluted, deconvolutednative, nativeamu, amuadvancebio, advancebiomass, massrna, rnaantibody, antibodysirnas, sirnaslinker
Application NoteBiopharmaComprehensive Approachesto Higher-Order Structure ofIntact Proteins by Native MassSpectrometryAuthorsCaroline S. Chu,Patrick D. Perkins,Christian Klein, andAndrew GieschenAgilent Technologies, Inc.AbstractThis application note presents different approaches to native mass spectrometry(nMS) using Agilent high resolution mass spectrometers for analysis of intactproteins and noncovalent...
Key words
counts, countsmass, masscharge, chargenoncovalent, noncovalentnative, nativecomplexes, complexescapillary, capillarydehydrogenase, dehydrogenasedesalting, desaltingonline, onlineswarm, swarmvoltage, voltagegas, gasadh, adhmobility
Application NoteBiopharma/PharmaCharacterization of Antibody‑DrugConjugates Using 2D-LC andNative MSAuthorsDavid L. Wong andSarah M. StowAgilent Technologies, Inc.AbstractAntibody drug conjugates (ADCs), which comprise a monoclonal antibody (mAb)conjugated to a small molecule drug through synthetic linkers, have been afast-growing class of effective biotherapeutics in...
Key words
dimension, dimensiondar, daradc, adcadcs, adcssecond, secondnative, nativehic, hicadvancebio, advancebiocounts, countsfirst, firstmab, mabdrug, drugdeconvoluted, deconvolutedconjugated, conjugateddenatured
Agilent BiocolumnsAggregate/Fragment AnalysisApplication Compendium ContentsBackground2Getting Started3How to Guide - Size Exclusion Chromatography for BiomoleculeAnalysis - 5991-3651EN 4Featured Application NotesElevate Your mAb Aggregate Analysis - 5994-2709EN12222High-Resolution, High-Throughput Size Exclusion ChromatographyAnalysis of Monoclonal Antibodies - 5994-0828EN29Sensitive Native Mass Spectrometry of MacromoleculesUsing Standard Flow LC/MS...
Key words
return, returnsection, sectioncontents, contentsmau, mausec, secinsulin, insulinmin, minsize, sizeprotein, proteinmonomer, monomeradvancebio, advancebiotime, timeexclusion, exclusionaggregates, aggregatesaggregate
 

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Application NotePharma & BiopharmaMass Spectrometric Characterizationof Antibody-siRNA Conjugates usingthe Agilent 6545XT AdvanceBioLC/Q‑TOFAuthorDavid L. WongAgilent Technologies, Inc.AbstractSmall interfering RNAs (siRNAs) are a promising type of RNA-based therapeuticdrugs that demonstrate effectiveness on gene silencing through RNA interference(RNAi). However, due to the chemical...
Key words
sirna, sirnamab, mabconjugates, conjugatesintact, intactcounts, countsdeglycosylated, deglycosylateddeconvoluted, deconvolutednative, nativeamu, amuadvancebio, advancebiomass, massrna, rnaantibody, antibodysirnas, sirnaslinker
Application NoteBiopharmaComprehensive Approachesto Higher-Order Structure ofIntact Proteins by Native MassSpectrometryAuthorsCaroline S. Chu,Patrick D. Perkins,Christian Klein, andAndrew GieschenAgilent Technologies, Inc.AbstractThis application note presents different approaches to native mass spectrometry(nMS) using Agilent high resolution mass spectrometers for analysis of intactproteins and noncovalent...
Key words
counts, countsmass, masscharge, chargenoncovalent, noncovalentnative, nativecomplexes, complexescapillary, capillarydehydrogenase, dehydrogenasedesalting, desaltingonline, onlineswarm, swarmvoltage, voltagegas, gasadh, adhmobility
Application NoteBiopharma/PharmaCharacterization of Antibody‑DrugConjugates Using 2D-LC andNative MSAuthorsDavid L. Wong andSarah M. StowAgilent Technologies, Inc.AbstractAntibody drug conjugates (ADCs), which comprise a monoclonal antibody (mAb)conjugated to a small molecule drug through synthetic linkers, have been afast-growing class of effective biotherapeutics in...
Key words
dimension, dimensiondar, daradc, adcadcs, adcssecond, secondnative, nativehic, hicadvancebio, advancebiocounts, countsfirst, firstmab, mabdrug, drugdeconvoluted, deconvolutedconjugated, conjugateddenatured
Agilent BiocolumnsAggregate/Fragment AnalysisApplication Compendium ContentsBackground2Getting Started3How to Guide - Size Exclusion Chromatography for BiomoleculeAnalysis - 5991-3651EN 4Featured Application NotesElevate Your mAb Aggregate Analysis - 5994-2709EN12222High-Resolution, High-Throughput Size Exclusion ChromatographyAnalysis of Monoclonal Antibodies - 5994-0828EN29Sensitive Native Mass Spectrometry of MacromoleculesUsing Standard Flow LC/MS...
Key words
return, returnsection, sectioncontents, contentsmau, mausec, secinsulin, insulinmin, minsize, sizeprotein, proteinmonomer, monomeradvancebio, advancebiotime, timeexclusion, exclusionaggregates, aggregatesaggregate
 

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