Similar PDF

Toggle
Application NotePharma & BiopharmaMass Spectrometric Characterizationof Antibody-siRNA Conjugates usingthe Agilent 6545XT AdvanceBioLC/Q‑TOFAuthorDavid L. WongAgilent Technologies, Inc.AbstractSmall interfering RNAs (siRNAs) are a promising type of RNA-based therapeuticdrugs that demonstrate effectiveness on gene silencing through RNA interference(RNAi). However, due to the chemical...
Key words
sirna, sirnamab, mabconjugates, conjugatesintact, intactcounts, countsdeglycosylated, deglycosylatednative, nativedeconvoluted, deconvolutedamu, amuadvancebio, advancebiomass, massrna, rnaantibody, antibodysirnas, sirnaslinker
Precise Characterization of IntactMonoclonal Antibodies by theAgilent 6545XT AdvanceBio LC/Q-TOFApplication NoteAuthorIntroductionDavid L. WongMonoclonal antibodies (mAbs) are a very important class of biopharmaceuticalmolecules. As a protein drug, thorough characterization of the mAb is required in eachof the manufacturing steps. Intact mAb...
Key words
glcnac, glcnacintact, intactbioconfirm, bioconfirmdeconvoluted, deconvolutedmass, massdeconvolution, deconvolutionamu, amudar, darantibodies, antibodiesmab, mabglycoforms, glycoformscounts, countsmaxent, maxententropy, entropymonoclonal
Application NoteBiopharmaComprehensive Approachesto Higher-Order Structure ofIntact Proteins by Native MassSpectrometryAuthorsCaroline S. Chu,Patrick D. Perkins,Christian Klein, andAndrew GieschenAgilent Technologies, Inc.AbstractThis application note presents different approaches to native mass spectrometry(nMS) using Agilent high resolution mass spectrometers for analysis of intactproteins and noncovalent...
Key words
counts, countsmass, masscharge, chargenoncovalent, noncovalentnative, nativecomplexes, complexesdehydrogenase, dehydrogenasedesalting, desaltingcapillary, capillaryonline, onlinevoltage, voltageswarm, swarmmobility, mobilityprotein, proteingas
Poster ReprintASMS 2020MP 499High Throughput Native MS WithRobust Ion Source Operation ForThe Analysis Of Proteins AndProtein ComplexesCaroline S. Chu, Patrick D. Perkins, ChristianKleinAgilent Technologies, Santa Clara, CA USA IntroductionNative mode proteins and protein complexes aretypically analyzed using nanospray techniques or atcapillary...
Key words
complexes, complexesnative, nativetetramer, tetramerprotein, proteinadh, adhparameter, parametersource, sourcestate, statecharge, chargeproteins, proteinsflow, flowion, ionklein, kleinvalue, valuesheath
 

Similar PDF

Toggle
Application NotePharma & BiopharmaMass Spectrometric Characterizationof Antibody-siRNA Conjugates usingthe Agilent 6545XT AdvanceBioLC/Q‑TOFAuthorDavid L. WongAgilent Technologies, Inc.AbstractSmall interfering RNAs (siRNAs) are a promising type of RNA-based therapeuticdrugs that demonstrate effectiveness on gene silencing through RNA interference(RNAi). However, due to the chemical...
Key words
sirna, sirnamab, mabconjugates, conjugatesintact, intactcounts, countsdeglycosylated, deglycosylatednative, nativedeconvoluted, deconvolutedamu, amuadvancebio, advancebiomass, massrna, rnaantibody, antibodysirnas, sirnaslinker
Precise Characterization of IntactMonoclonal Antibodies by theAgilent 6545XT AdvanceBio LC/Q-TOFApplication NoteAuthorIntroductionDavid L. WongMonoclonal antibodies (mAbs) are a very important class of biopharmaceuticalmolecules. As a protein drug, thorough characterization of the mAb is required in eachof the manufacturing steps. Intact mAb...
Key words
glcnac, glcnacintact, intactbioconfirm, bioconfirmdeconvoluted, deconvolutedmass, massdeconvolution, deconvolutionamu, amudar, darantibodies, antibodiesmab, mabglycoforms, glycoformscounts, countsmaxent, maxententropy, entropymonoclonal
Application NoteBiopharmaComprehensive Approachesto Higher-Order Structure ofIntact Proteins by Native MassSpectrometryAuthorsCaroline S. Chu,Patrick D. Perkins,Christian Klein, andAndrew GieschenAgilent Technologies, Inc.AbstractThis application note presents different approaches to native mass spectrometry(nMS) using Agilent high resolution mass spectrometers for analysis of intactproteins and noncovalent...
Key words
counts, countsmass, masscharge, chargenoncovalent, noncovalentnative, nativecomplexes, complexesdehydrogenase, dehydrogenasedesalting, desaltingcapillary, capillaryonline, onlinevoltage, voltageswarm, swarmmobility, mobilityprotein, proteingas
Poster ReprintASMS 2020MP 499High Throughput Native MS WithRobust Ion Source Operation ForThe Analysis Of Proteins AndProtein ComplexesCaroline S. Chu, Patrick D. Perkins, ChristianKleinAgilent Technologies, Santa Clara, CA USA IntroductionNative mode proteins and protein complexes aretypically analyzed using nanospray techniques or atcapillary...
Key words
complexes, complexesnative, nativetetramer, tetramerprotein, proteinadh, adhparameter, parametersource, sourcestate, statecharge, chargeproteins, proteinsflow, flowion, ionklein, kleinvalue, valuesheath
 

Related content

Evaluating the Waters ACQUITY Premier System as a Flexible LC Platform That Can Be Broadly Deployed in Biopharmaceutical Labs

Applications
| 2021 | Waters
Instrumentation
HPLC, GPC/SEC
Manufacturer
Waters
Industries
Pharma & Biopharma

Analysis of 510 Pesticide Residues in Honey and Onion on an Agilent 6470 Triple Quadrupole LC/MS System

Applications
| 2021 | Agilent Technologies
Instrumentation
LC/MS, LC/MS/MS, LC/QQQ
Manufacturer
Agilent Technologies
Industries
Food & Agriculture

Rapid Detection of Illicit Drugs and Psychoactive Plant Component by Green Technology DPiMSTM-8060

Applications
| 2021 | Shimadzu
Instrumentation
LC/MS, LC/MS/MS, LC/QQQ, DART
Manufacturer
Shimadzu
Industries
Forensics
 

Related content

Evaluating the Waters ACQUITY Premier System as a Flexible LC Platform That Can Be Broadly Deployed in Biopharmaceutical Labs

Applications
| 2021 | Waters
Instrumentation
HPLC, GPC/SEC
Manufacturer
Waters
Industries
Pharma & Biopharma

Analysis of 510 Pesticide Residues in Honey and Onion on an Agilent 6470 Triple Quadrupole LC/MS System

Applications
| 2021 | Agilent Technologies
Instrumentation
LC/MS, LC/MS/MS, LC/QQQ
Manufacturer
Agilent Technologies
Industries
Food & Agriculture

Rapid Detection of Illicit Drugs and Psychoactive Plant Component by Green Technology DPiMSTM-8060

Applications
| 2021 | Shimadzu
Instrumentation
LC/MS, LC/MS/MS, LC/QQQ, DART
Manufacturer
Shimadzu
Industries
Forensics
Other projects
Follow us
More information
WebinarsAbout usContact usTerms of use

LabRulez s.r.o., all rights reserved.