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Characterization of Antibody‑Drug Conjugates Using 2D-LC and Native MS

Applications | 2021 | Agilent TechnologiesInstrumentation
LC/TOF, LC/HRMS, LC/MS, LC/MS/MS, 2D-LC, GPC/SEC
Industries
Pharma & Biopharma
Manufacturer
Agilent Technologies
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Poster Reprint ASMS 2021 Poster number ThP003 Characterization of Antibody-Drug Conjugates (ADC) using 2-Dimension Liquid Chromatography (2D-LC) and Native Mass Spectrometric Technologies David L. Wong and Sarah M. Stow Agilent Technologies, Inc., Santa Clara, CA, USA Introduction Antibody drug conjugates…
Key words
drug, drughic, hicadc, adcantibody, antibodyadvancebio, advancebiodar, darmab, mabintact, intactconjugates, conjugatesbrentuximab, brentuximabvedotin, vedotinnative, nativeconjugated, conjugatedspectrometric, spectrometrichydrophobic
Application Note Biotherapeutics & Biosimilars Drug to Antibody Ratio Analysis of Brentuximab Vedotin in Monkey Plasma Antibody drug conjugate analysis under native conditions using Agilent AdvanceBio 6545XT LC/Q-TOF systems Authors Xi Qiu and Kenda LJ Evans Agilent Technologies, Inc. Andrea…
Key words
brentuximab, brentuximabdar, darmonkey, monkeylba, lbaadc, adcamu, amudeconvoluted, deconvoluteddrug, drugcounts, countsadcs, adcsnative, nativeantibody, antibodyassaymap, assaymapagilent, agilentbravo
Consumables Workflow Ordering Guide Improving the Quality of Antibody Drug Conjugates by Orthogonal Analytical Methods Antibody Drug Conjugates Antibody-drug conjugates (ADCs) represent a new generation of targeted biotherapeutics that make up a rapidly growing segment of the drug discovery pipeline.…
Key words
mylist, mylistcysteine, cysteinedar, daradc, adcadcs, adcslysine, lysinelinker, linkercolumn, columnhic, hicauristatin, auristatinvedotin, vedotinantibody, antibodymmae, mmaeintact, intactinfinitylab
Application Note Biopharma High Salt—High Reproducibility Analysis of antibody drug conjugates using hydrophobic interaction chromatography with the Agilent 1290 Infinity II Bio LC System Response (mAU) ×101 D2 3.4 3.2 3.0 2.8 2.6 2.4 2.2 2.0 1.8 1.6 1.4 1.2…
Key words
dar, darhic, hicbrentuximab, brentuximabvedotin, vedotinantibody, antibodydrug, drugsubtraction, subtractionbiocompatible, biocompatiblearea, areaadc, adcsalt, saltmolecules, moleculesprecision, precisionmau, mauspecies
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