Characterization of Antibody Drug Conjugates (ADC) using 2-Dimension Liquid Chromatography (2D-LC) and Native Mass Spectrometric Technologies
Posters | 2021 | Agilent Technologies | ASMSInstrumentation
LC/TOF, LC/HRMS, LC/MS, LC/MS/MS, 2D-LC
IndustriesPharma & Biopharma
ManufacturerAgilent Technologies
Key wordsdrug, hic, adc, antibody, advancebio, dar, mab, intact, conjugates, brentuximab, vedotin, native, conjugated, spectrometric, hydrophobic, exclusion, auristatin, dars, molecule, interaction, mass, thiol, monomethyl, characterization, lyophilized, various, size, small, denatured, comprises, ratio, desalting, under, cysteine, accurate, technique, reprint, partially, performs, determination, attributes, utilizes, deconvoluted, poster, discussion, files, dissolved, using, analysis, methodology
Similar PDF
Characterization of Antibody‑Drug Conjugates Using 2D-LC and Native MS
2021|Agilent Technologies|Applications
Application Note Biopharma/Pharma Characterization of Antibody‑Drug Conjugates Using 2D-LC and Native MS Authors David L. Wong and Sarah M. Stow Agilent Technologies, Inc. Abstract Antibody drug conjugates (ADCs), which comprise a monoclonal antibody (mAb) conjugated to a small molecule drug…
Key words
dimension, dimensiondar, daradcs, adcsadc, adcsecond, secondnative, nativehic, hicadvancebio, advancebiocounts, countsmab, mabdrug, drugdeconvoluted, deconvolutedfirst, firstconjugated, conjugatedintact
Improving the Quality of Antibody Drug Conjugates by Orthogonal Analytical Methods
2024|Agilent Technologies|Guides
Consumables Workflow Ordering Guide Improving the Quality of Antibody Drug Conjugates by Orthogonal Analytical Methods Antibody Drug Conjugates Antibody-drug conjugates (ADCs) represent a new generation of targeted biotherapeutics that make up a rapidly growing segment of the drug discovery pipeline.…
Key words
mylist, mylistcysteine, cysteinedar, daradc, adcadcs, adcslysine, lysinecolumn, columnlinker, linkerhic, hicauristatin, auristatinvedotin, vedotinantibody, antibodymmae, mmaeintact, intactinfinitylab
Drug to Antibody Ratio Analysis of Brentuximab Vedotin in Monkey Plasma
2024|Agilent Technologies|Applications
Application Note Biotherapeutics & Biosimilars Drug to Antibody Ratio Analysis of Brentuximab Vedotin in Monkey Plasma Antibody drug conjugate analysis under native conditions using Agilent AdvanceBio 6545XT LC/Q-TOF systems Authors Xi Qiu and Kenda LJ Evans Agilent Technologies, Inc. Andrea…
Key words
brentuximab, brentuximabdar, darmonkey, monkeylba, lbaadc, adcamu, amudeconvoluted, deconvoluteddrug, drugcounts, countsadcs, adcsnative, nativeantibody, antibodyassaymap, assaymapagilent, agilentbravo
Analysis of Cysteine-Linked Antibody Drug Conjugates
2017|Agilent Technologies|Applications
Analysis of Cysteine-Linked Antibody Drug Conjugates Using Hydrophobic Interaction Chromatography on the Agilent 1260 Infinity II Bio-inert LC Application Note Biologics and Biosimilars Author Abstract Sonja Schneider Hydrophobic interaction chromatography (HIC) is frequently used for the Agilent Technologies, Inc. determination…
Key words
brentuximab, brentuximabvedotin, vedotindar, darhic, hicdrug, drugantibody, antibodyhydrophobic, hydrophobicmmae, mmaeadcs, adcsadc, adctige, tigeinteraction, interactionmab, mablinked, linkedtrastuzumab