Mass Spectrometric Characterization of Antibody-siRNA Conjugates using the Agilent 6545XT AdvanceBio LC/Q‑TOFApplications | 2020 | Agilent TechnologiesInstrumentationLC/TOF, LC/HRMS, LC/MS, LC/MS/MSIndustriesPharma & BiopharmaManufacturerAgilent TechnologiesKey wordssirna, mab, conjugates, intact, counts, deglycosylated, native, deconvoluted, amu, advancebio, mass, rna, antibody, sirnas, linker, charge, conjugation, under, denaturing, conjugate, spectrum, characterization, protein, acquisition, sec, exchange, molecules, oligonucleotide, agilent, rnai, rnas, silencing, were, dissociated, purified, analysis, unconjugated, tof, preserving, covalently, column, reduced, using, cap, jet, biogenic, various, stream, raw, reduction
Sensitive Native Mass Spectrometry of Macromolecules Using Standard Flow LC/MS
Application NotePharma & BiopharmaSensitive Native Mass Spectrometryof Macromolecules Using StandardFlow LC/MSAuthorDavid L. WongAgilent Technologies, Inc.AbstractNative mass spectrometry can be used for a variety of protein-based applications,such as protein-protein interaction, protein-ligand binding, protein complexstructures, protein folding and antibody-drug conjugates. Most of...
native, nativeprotein, proteincounts, countsintact, intactdeconvoluted, deconvolutedmyoglobin, myoglobinapomyoglobin, apomyoglobinamu, amucharge, chargemass, masscomplexes, complexesheme, hemeholomyoglobin, holomyoglobindenatured, denaturedtetramer
Intact & Subunit Analysis Using Reversed Phase - Agilent BioHPLC Columns Application Compendium
Agilent-NISTmAbIntact & Subunit AnalysisUsing Reversed PhaseAgilent BioHPLC ColumnsApplication CompendiumContentsAgilent-NISTmAb Standard (P/N 5191-5744; 5191-5745) was aliquoted fromNISTmAb RM 8671 batch. Quality control (QC) testing is performed usingAgilent LC-MS system. QC batch release test includes aggregate profile, chargevariants and intact mass information....
counts, countsmab, mabintact, intactherceptin, herceptinpage, pagecontents, contentsbonds, bondsback, backdeglycosylated, deglycosylatedmass, massdeconvoluted, deconvolutedides, idesamu, amubravo, bravoantibodies
Size Exclusion Chromatography/ Mass Spectrometry Analysis of Antibody Drug Conjugates Using the Agilent 1260 Infinity II Bio-Inert LC
Size Exclusion Chromatography/Mass Spectrometry Analysis ofAntibody Drug Conjugates Using theAgilent 1260 Infinity II Bio-Inert LCApplication NoteBiologics & BiosimilarsAuthorAbstractSonja SchneiderRecombinant monoclonal antibodies (mAbs) have emerged as importantAgilent Technologies, Inc.therapeutic agents for the treatment of different diseases1. These biotherapeuticsWaldbronn, Germanyhave been extended...
adcs, adcsdeconvoluted, deconvolutedadc, adctrastuzumab, trastuzumabdeglycosylated, deglycosylatedmass, massdrug, drugcounts, countsantibody, antibodysec, seclinker, linkerspectrum, spectrumcharge, chargedar, darconjugates
Mass Spectrometric Characterization of Antibody-RNA Conjugates using the Agilent 6545XT AdvanceBio LC/Q-TOF
Poster ReprintASMS 2020WP 004Mass SpectrometricCharacterization of Antibody-RNAConjugates using the Agilent6545XT AdvanceBio LC/Q-TOFDavid L. WongAgilent Technologies, Inc., Santa Clara, CA,USAIntroductionExperimentalAntibody-RNA Conjugates have drug-likeThe antibody was partially reduced withproperties comparable to antibodies and allowreducing agent and was then reacted with thedelivery of...
conjugates, conjugatesrna, rnamab, mabantibody, antibodycondition, conditionadvancebio, advancebiosirna, sirnaunder, undernative, nativedenaturing, denaturingthiomab, thiomabintact, intactdelivery, deliveryspanned, spannedpayloads