Label-free compound profiling in K562 leukemia cells by MALDI-TOF mass spectrometry using heme B as response marker
Applications | 2019 | BrukerInstrumentation
MALDI, LC/TOF, LC/MS, LC/MS/MS
IndustriesClinical Research
ManufacturerBruker
Key wordsmaldi, rapiflex, abl, bcr, inhibitors, laser, heme, cells, marker, tof, response, imatinib, pharmacodynamic, intensity, automated, assays, chloroquine, drug, kinase, cybio, felix, cell, concentrationdependent, pharmapulse, dasatinib, robot, mrms, assay, bruker, reflector, shots, measured, mass, metabolic, freezing, label, cultivation, whole, snap, signal, free, vehicle, accumulated, plate, biochemical, cellular, were, tyrosine, polyacetylated, underexplored
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Kinase inhibition screening by label-free mass spectrometry employing the MALDI PharmaPulse HTS solution
2020|Bruker|Applications
© Title Image - Analytik Jena Kinase inhibition screening by label-free mass spectrometry employing the MALDI PharmaPulse HTS solution Bruker´s MALDI PharmaPulse solution, integrating the rapifleX high-speed MALDI-TOF instrument with the dedicated MALDI PharmaPulse software suite, represents an emerging technology…
Key words
maldi, maldipharmapulse, pharmapulsekinase, kinaseabl, ablbruker, brukerhts, htssubstrate, substrateinhibitor, inhibitormpp, mppinhibition, inhibitionrapiflex, rapiflexenzyme, enzymetof, tofconversion, conversiontyrosine
Profiling mammalian cell differentiation by MALDI-TOF MS: Developing a highly reproducible and robust sample preparation workflow
2020|Bruker|Applications
Profiling mammalian cell differentiation by MALDI-TOF MS: Developing a highly reproducible and robust sample preparation workflow In this application note, we present a universal workflow for mammalian cell MALDI-TOF MS analysis in order to distinguish between ground-state naïve and differentiating…
Key words
maldi, malditof, tofrapiflex, rapiflexfreeze, freezelaser, laserpharmapulse, pharmapulsenaïve, naïvethaw, thawhts, htsassays, assayscell, cellcells, cellscellular, cellularthawing, thawingdhb
Label-free drug uptake analysis of whole cells by MALDI-TOF mass spectrometry using the transport protein OATP2B1 as an example
2020|Bruker|Applications
Label-free drug uptake analysis of whole cells by MALDI-TOF mass spectrometry using the transport protein OATP2B1 as an example In this application note, we demonstrate a MALDI MS cellular drug uptake and inhibition assay [1]. It was conducted in HEK293…
Key words
maldi, maldirapiflex, rapiflexreadouts, readoutsuptake, uptakeradiolabelled, radiolabelledcybio, cybiodrug, drugdroplet, droplettransport, transportcells, cellsinhibition, inhibitionscreening, screeningcell, cellinhibitors, inhibitorsassay
Novel MALDI-TOF MS Workflow for Ultrahigh-Throughput Screening of Different Analytes at Each Position on a Plate
2020|Bruker|Applications
Novel MALDI-TOF MS Workflow for Ultrahigh-Throughput Screening of Different Analytes at Each Position on a Plate Novel Synthesis Screening workflow in MALDI PharmaPulse software that was developed for screening of synthetic chemical reactions is applied to screen a custom library…
Key words
maldi, maldiscreening, screeningsynthesis, synthesisplate, platepharmapulse, pharmapulsetof, toffailed, failedultrahigh, ultrahighposition, positionruns, runsmolecule, moleculelibrary, librarynovel, novelphotoredox, photoredoxmodule