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High-throughput experimentation reaction monitoring and analysis of chemistry synthesis products with ultrahigh-throughput 4D timsTOF fleX MALDI-2 technology

Applications | 2021 | BrukerInstrumentation
Ion Mobility, LC/TOF, LC/HRMS, LC/MS, LC/MS/MS
Industries
Energy & Chemicals , Pharma & Biopharma, Others
Manufacturer
Bruker
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Intensity (arb. unit) 132% 0% 100% PS 38:1 m/z 816.5747 ± 0.0122 1/K0 1.433 ± 0.01 Intensity (arb. unit) Mobility [1/K0] 136% 0% 100% PE 20:1_22:6 m/z 816.5517 ± 0.0122 1/K0 1.404 ± 0.01 m/z 1 mm CCS-aware SpatialOMx® enables…
Key words
ccs, ccsmaldi, maldispatialomx, spatialomximaging, imagingaware, awareannotation, annotationtims, timsmobility, mobilityannotated, annotatedannotations, annotationsbucket, bucketpasef, paseflipid, lipidsegmentation, segmentationimages
Next-generation MALDI top-down sequencing of protein biotherapeutics – expanding the scope of timsTOF technology Next-generation MALDI top-down sequencing (MALDI-TDS) improves top-down sequence analysis of biopharmaceutical proteins, as demonstrated in this note for adalimumab subunits, recombinant SARS-CoV-2 S-glycoprotein RBD expression products,…
Key words
maldi, malditds, tdsterminal, terminalisd, isdtims, timsnext, nextgeneration, generationsequence, sequencesequencing, sequencingprotein, proteintimstof, timstoffragments, fragmentssubunits, subunitsflex, flexdown
TIMS enabled quantification of small molecules in MALDI Imaging timsTOF fleX was used to demonstrate quantitative mass spectrometry imaging on several drug compounds. Abstract timsTOF fleX was able to separate near-isobaric ions by their ion mobilities, significantly improving targeted compound…
Key words
timstof, timstofflex, flexmaldi, malditims, timsions, ionsgadavist, gadavisttopotecan, topotecanisobaric, isobaricqmsi, qmsitissue, tissuemmae, mmaeimaging, imagingintensity, intensitydrug, drughomogenate
4D-Lipidomics™ workflow for increased throughput Lipid profiling from complex lipid extracts can be a challenging and time consuming task. The high complexity of samples and co-elution of isobaric or isomeric compounds complicate the confident annotation of lipids. The presented 4D-Lipidomics…
Key words
ccs, ccsannotation, annotationlipid, lipidannotations, annotationslipids, lipidstimstof, timstofaware, awarebased, basedcoverage, coveragevalues, valuesdeep, deepcan, canmobility, mobilityrule, ruleannotated
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