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Next-generation MALDI top-down sequencing of protein biotherapeutics – expanding the scope of timsTOF technology

 

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Recombinant SARS-CoV-2 Receptor Binding Domain: Comprehensive Top-Down Sequence Confirmation, Curation and O-Glycosylation Site Determination Know your SARS-CoV-2 antigen structure before it´s use in research and diagnostics Abstract The COVID pandemic dramatically influences our life and the demand remains very high…
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Extensive LC-Top-Down MS Sequence Confirmation of the NISTmAb Reference Material 8671 Characterization of therapeutic antibodies aims on primary sequence validation, localization of modifications such as glycan profiles and the determination of disulfide bond status of the target molecule. Introduction Typically,…
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How to Determine Glycan Profiles of Biopharmaceuticals from Peptide Mapping Data A new and sensitive approach combining BioPharma Compass, PASEF and VIP-HESI Abstract Glycosylation is a common critical quality attribute (CQA) of therapeutic proteins and needs to be characterized during…
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MALDI-2 for enhanced in situ N-glycan analysis N-glycans are important players in a variety of pathologies including different types of cancer, (auto)immune diseases, and also viral infections. Abstract Matrix-assisted laser desorption/ ionization mass spectrometry (MALDI-MS) is an important tool for…
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