An automated method to study the rapid intramolecular transacylation of drug acyl glucuronides using Cyclic Ion Mobility Spectrometry-Mass Spectrometry
Posters | 2021 | WatersInstrumentation
Ion Mobility, LC/TOF, LC/HRMS, LC/MS, LC/MS/MS
IndustriesPharma & Biopharma
ManufacturerWaters
Key wordstransacylation, mobility, acyl, incubation, isomers, ims, cyclic, migration, systemand, probabilistically, rapid, half, room, glucuronidation, automated, calculation, method, disappearance, plot, intramolecular, incubating, cim, spectrometry, incubations, monitor, glucuronides, real, biotransformation, select, life, infused, procedure, ion, naproxen, time, waters, metabolome, collisional, likelihood, study, undertaken, monitoring, ccs, passes, samples, mass, infusion, carboxylic, provide, estimate
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An automated method to study the rapid intramolecular transacylation of drug acyl glucuronides using Cyclic Ion Mobility Spectrometry-Mass Spectrometry
2021|Waters|Posters
An automated method to study the rapid intramolecular transacylation of drug acyl glucuronides using Cyclic Ion Mobility Spectrometry-Mass Spectrometry David Higton (Waters Corp, UK), Ian D Wilson (Imperial College, London, UK), Johannes P C Vissers (Waters Corp,UK), Robert S Plumb…
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cyclic, cyclicacyl, acylims, imsincubation, incubationglucuronides, glucuronidesmobility, mobilityreal, realtransacylation, transacylationhalf, halfglucuronidation, glucuronidationnag, nagcalculation, calculationion, ionags, agsintramolecular
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ims, imsccs, ccscims, cimsmetabolite, metaboliteacyl, acyllocalisation, localisationpasses, passesinfusion, infusionslicing, slicingcyclic, cyclicranitidine, ranitidinediscover, discoverfamiliarisation, familiarisationimsⁿ, imsⁿlanshoeft
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ims, imscyclic, cyclicselect, selectseries, seriesmetabolites, metabolitesccs, ccsmobility, mobilityisomeric, isomericidentical, identicalvalues, valuesstructural, structuralseparation, separationion, ionhigton, higtonelucidation
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cyclic, cyclicims, imsmobility, mobilityisomeric, isomericbile, bileisomers, isomersdifferent, differentbiologically, biologicallytwo, twometabolites, metabolitesbiochemical, biochemicalultimately, ultimatelymass, massacids, acidsfurthering