ASMS 2021: An automated method to study the rapid intramolecular transacylation of drug acyl glucuronides using Cyclic Ion Mobility Spectrometry-Mass Spectrometry | LabRulez LCMS
 

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An automated method to study the rapid intramoleculartransacylation of drug acyl glucuronides using Cyclic Ion MobilitySpectrometry-Mass SpectrometryDavid Higton1 , Ian D Wilson2, Johannes P C Vissers1, Robert S Plumb31.Waters Corp, Wilmslow, UK 2.Imperial College, London, UK 3.Waters Corp, Milford, UKcontact...
Key words
transacylation, transacylationmobility, mobilityacyl, acylincubation, incubationisomers, isomerscyclic, cyclicims, imsmigration, migrationsystemand, systemandprobabilistically, probabilisticallyrapid, rapidroom, roomhalf, halfautomated, automatedcalculation
[[ PRODUCTPRODUCT SOLUTIONSOLUTION ]]Revolutionize Metabolite Identification with Cyclic IMSDiscover, Identify and Monitor moreWHY SELECT SERIES CYCLIC IMS?SELECT SERIESTM CyclicTM IMS adds benefit to pharma workflows. Ultra-highion mobility resolution and novel multi-stage IMSn capability enables discoveryof co-eluting, isomeric metabolites, rapid monitoring...
Key words
ims, imsccs, ccscims, cimsmetabolite, metaboliteacyl, acyllocalisation, localisationpasses, passescyclic, cyclicslicing, slicinginfusion, infusionranitidine, ranitidinediscover, discovervia, viamigration, migrationfamiliarisation
DETERMINATION OF THE RELATIVE CCS OF PESTICIDE PROTOMERS AND CONFORMERS USING LINEARAND MULTI-PASS CYCLIC TWIM ION MOBILITY SPECTROMETRY1Michael McCullagh, 1Martin Palmer, 1Alexander Muck, 2Séverine Goscinny and 1Jakub Ujma.1Waters Corporation, Stamford Avenue, Altrincham Road, Wilmslow, SK9 4AX. UK. 2. Sciensano, 14,...
Key words
twim, twimcim, cimccs, ccscharged, chargedconformer, conformerisomer, isomerlinear, linearinvestigations, investigationsmobility, mobilitysite, sitespecies, speciespass, passformation, formationconformers, conformersdescriptor
Application NoteUse of Predicted Versus Measured CCSValues from Different Instrument Platforms,and Isomer Separation on the SELECTSERIES Cyclic IMSDavid Higton, Christian Lanshoeft, Frederic Lozac'hWaters Corporation, Novartis Pharma AGAbstractBiotransformation activities require the comparison of metabolites across species and studies. In general,chromatographic retention...
Key words
cyclic, cyclicims, imsselect, selectseries, seriesmetabolites, metabolitesccs, ccsmobility, mobilityisomeric, isomericidentical, identicalvalues, valuesstructural, structuralseparation, separationion, ionspectral, spectralelucidation
 

Similar PDF

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An automated method to study the rapid intramoleculartransacylation of drug acyl glucuronides using Cyclic Ion MobilitySpectrometry-Mass SpectrometryDavid Higton1 , Ian D Wilson2, Johannes P C Vissers1, Robert S Plumb31.Waters Corp, Wilmslow, UK 2.Imperial College, London, UK 3.Waters Corp, Milford, UKcontact...
Key words
transacylation, transacylationmobility, mobilityacyl, acylincubation, incubationisomers, isomerscyclic, cyclicims, imsmigration, migrationsystemand, systemandprobabilistically, probabilisticallyrapid, rapidroom, roomhalf, halfautomated, automatedcalculation
[[ PRODUCTPRODUCT SOLUTIONSOLUTION ]]Revolutionize Metabolite Identification with Cyclic IMSDiscover, Identify and Monitor moreWHY SELECT SERIES CYCLIC IMS?SELECT SERIESTM CyclicTM IMS adds benefit to pharma workflows. Ultra-highion mobility resolution and novel multi-stage IMSn capability enables discoveryof co-eluting, isomeric metabolites, rapid monitoring...
Key words
ims, imsccs, ccscims, cimsmetabolite, metaboliteacyl, acyllocalisation, localisationpasses, passescyclic, cyclicslicing, slicinginfusion, infusionranitidine, ranitidinediscover, discovervia, viamigration, migrationfamiliarisation
DETERMINATION OF THE RELATIVE CCS OF PESTICIDE PROTOMERS AND CONFORMERS USING LINEARAND MULTI-PASS CYCLIC TWIM ION MOBILITY SPECTROMETRY1Michael McCullagh, 1Martin Palmer, 1Alexander Muck, 2Séverine Goscinny and 1Jakub Ujma.1Waters Corporation, Stamford Avenue, Altrincham Road, Wilmslow, SK9 4AX. UK. 2. Sciensano, 14,...
Key words
twim, twimcim, cimccs, ccscharged, chargedconformer, conformerisomer, isomerlinear, linearinvestigations, investigationsmobility, mobilitysite, sitespecies, speciespass, passformation, formationconformers, conformersdescriptor
Application NoteUse of Predicted Versus Measured CCSValues from Different Instrument Platforms,and Isomer Separation on the SELECTSERIES Cyclic IMSDavid Higton, Christian Lanshoeft, Frederic Lozac'hWaters Corporation, Novartis Pharma AGAbstractBiotransformation activities require the comparison of metabolites across species and studies. In general,chromatographic retention...
Key words
cyclic, cyclicims, imsselect, selectseries, seriesmetabolites, metabolitesccs, ccsmobility, mobilityisomeric, isomericidentical, identicalvalues, valuesstructural, structuralseparation, separationion, ionspectral, spectralelucidation
 

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