Analysis of siRNA Duplexes at Non- Denaturing UPLC Conditions Using MaxPeak Premier Column Technology
Applications | 2021 | WatersInstrumentation
HPLC
IndustriesPharma & Biopharma
ManufacturerWaters
Key wordsduplexes, sirna, denaturing, premier, maxpeak, uplc, non, technology, stranded, conditions, column, analysis, oligonucleotides, using, duplex, johnson, single, frits, oligonucleotide, analogyes, acquity, excess, oligodeoxyribonucleotides, pair, coping, adsorption, method, nondenaturing, columns, diastereomeric, reversed, phosphorothioate, impurities, strand, modest, separation, unmodified, titanium, explored, metallic, undesirable, nucleic, suspected, suffer, desirable, positively, construction, formulations, estimate, chromatographic
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[ APPLICATION NOTEBOOK ] APPLICATION SOLUTIONS FOR OLIGONUCLEOTIDES Table of Contents Introduction – UPLC Analysis of Synthetic Oligonucleotides......................................................................................................................... 4 [ HPLC & UPLC Separations ] Real-Time Analysis of RNAi Duplexes ....................................................................................................................................................................... 8 Semi-Preparative Scale Single-Stranded RNA Purification .......................................................................................................................... 11 Oligonucleotide…
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