Thermo Scientific Vanquish Diode Array Detectors and Multi Wavelength Detectors - PRODUCT SPECIFICATIONS

Significance of Topic

Diode array and multiple wavelength detectors are essential tools in liquid chromatography workflows, offering detailed spectral data for qualitative and quantitative analysis of complex samples. Their ability to detect analytes over a broad dynamic range with high sensitivity and reproducibility is critical in pharmaceutical, environmental, food safety, and chemical research laboratories

Objectives and Study Overview

This summary reviews the features and performance of Thermo Scientific Vanquish DAD and MWD series detectors, outlining the design principles, operational capabilities, and application flexibility of the HL, FG, CG diode array detectors and the CG multiple wavelength detector from the Vanquish platform

Applied Methodology and Instrumentation

The Vanquish DADs and MWDs employ a single-beam reverse-optics layout with concave holographic gratings and achromatic lenses focusing light onto a 1024 element photodiode array. The primary light sources include deuterium lamps for UV range detection and tungsten lamps for VIS range extension. Optical parameters such as slit width can be adjusted from 1 to 8 nm, and internal calibration uses the D-alpha line; validation relies on a holmium oxide filter. Data acquisition rates reach up to 250 Hz for 3D spectra and up to 200 Hz for scanning. System health is monitored through power-up diagnostics, leak detection and predictive maintenance features integrated with Chromeleon CDS software GLP functions

Použitá instrumentace

• Vanquish Diode Array Detector HL, FG and CG models
• Vanquish Multiple Wavelength Detector CG
• LightPipe flow cells: standard (2 µL, 10 mm) and high sensitivity (13 µL, 60 mm)
• Biocompatible and standard flow cells for FG and CG models with pressure limits up to 120 bar
• Deuterium and tungsten lamps, diagnostic and flushing kits, back-flush and overpressure relief accessories

Main Results and Discussion

• Wavelength range from 190 to 800 nm with pixel resolution down to 0.5 nm and optical resolution of 1 nm FWHM
• Low noise levels (<±3 µAU at 230 nm) and baseline drift (<0.5 mAU/h) ensure reliable trace detection
• Excellent linearity (<5% deviation at 2.0 AU) and wide dynamic range facilitate quantitation of main and minor components
• Fast data collection (up to 250 Hz) and multiple signal channels (up to 10 channels plus 3D field) support ultrafast separations
• Robust construction with PEEK, fused silica, titanium and MP35N wetted parts ensures chemical compatibility and pressure tolerance

Benefits and Practical Applications

• Enhanced productivity through rapid, reproducible analyses and minimal method development
• Seamless integration with LC-MS and other hyphenated techniques using low-dispersion flow cells
• Flexible configuration for high-throughput screening, method transfer and routine quality control
• Predictive maintenance reduces downtime and optimizes service intervals based on actual usage

Future Trends and Opportunities

Advancements in miniaturized detectors, extended wavelength coverage into the UV-VIS-NIR regions and real-time chemometric analysis are expected to drive next-generation chromatographic detection. Integration with artificial intelligence for automated data interpretation and remote system monitoring will further streamline laboratory workflows

Conclusion

Thermo Scientific Vanquish DAD and MWD detectors combine precision optics, robust engineering and intelligent diagnostics to deliver high sensitivity, linearity and flexibility across diverse liquid chromatography applications. Their modular design and predictive maintenance features ensure long-term performance and minimal downtime for quality-critical analyses

Reference

Thermo Fisher Scientific Inc. Product Specification PS73047-EN