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Incorporation of an Automated Scoring Metric for High-Resolution/Accurate-Mass Targeted Peptide Quantitation Routine

 

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APPLICATION NOTE 72916 A high-resolution accurate mass multi-attribute method for critical quality attribute monitoring and new peak detection Authors Haichuan Liu1, Royston Quintyn2, John Rontree3 Thermo Fisher Scientific 1 San Jose, CA 2 West Palm Beach, FL 3 Hemel Hempstead,…
Key words
intensity, intensitynistmab, nistmabmam, mamchromeleon, chromeleonpeptide, peptidestressed, stressedprtc, prtcratio, ratiothermo, thermoretention, retentionfinder, finderscientific, scientificcounts, countsbiopharma, biopharmaintegration
Improving Label-Free Quantification of Plasma and Serum Proteins Using a High-Resolution Hybrid Orbitrap Mass Spectrometer Maryann S. Vogelsang,1 Amol Prakash,1 David Sarracino,1 Scott Peterman,1 Bryan Krastins,1 Jennifer Sutton,1 Gregory Byram,1 Gouri Vadali,1 Shadab Ahmad,1 Bruno Darbouret, 2 Mary F. Lopez1…
Key words
acquisition, acquisitiontargeted, targetedlabel, labelspectral, spectralquantification, quantificationisotope, isotopeplasma, plasmawatch, watchreal, realdata, datapeptide, peptidefree, freebiomarker, biomarkervgdanpalqk, vgdanpalqkexpanded
Scott Peterman1, Kwasi Antwi2, Bryan Krastins1, Eric E. Niederkofler2, and Mary Lopez1 Thermo Fisher Scientific BRIMS, Cambridge, MA 2 Thermo Fisher Scientific, Tempe, AZ 1 Key Words Q Exactive, insulin, insulin variants, Pinpoint, HRAM, high resolution, accurate mass, MSIA, mass…
Key words
insulin, insulinanalogs, analogspinpoint, pinpointisotopic, isotopicdata, dataporcine, porcinemsia, msiaspiked, spikedauc, auctargeted, targetedvalues, valuesqualitative, qualitativewere, weredot, dotcharge
Low Attomole Limit of Quantification on an Orbitrap Fusion Introduction Lumos Tribrid Mass Spectrometer One of the major challenges in Proteomics is the quantification of low abundance proteins and peptides of biological relevance such as transcription factors or low stoichiometry…
Key words
fusion, fusionorbitrap, orbitraplumos, lumostribrid, tribridorbitrapfusion, orbitrapfusionlumostm, lumostmamol, amolprtc, prtcwisim, wisimduty, dutyngof, ngofofhela, ofhelafusionlumos, fusionlumostheorbitrap, theorbitrapconfident
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