Streamlining workflow from characterization to monitoring of therapeutic oligonucleotides impurities across IPRP-LC-HRAM-MS platforms
Posters | 2022 | Thermo Fisher Scientific | ASMSInstrumentation
LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap
IndustriesPharma & Biopharma
ManufacturerThermo Fisher Scientific
Key wordsoligonucleotide, characterization, spet, impurities, exploris, identified, iprp, orbitrap, monitoring, predicted, thermo, eworkflow, scientific, metrics, oligonucleotides, platforms, abundance, gave, workflow, performance, vanquish, system, comparable, relative, chromeleon, correlation, fragmentation, detectors, flp, monitor, mass, divide, dnapac, against, evaluation, evaluates, streamlining, procedure, spectra, results, deployed, relating, developed, monoisotopic, horizon, characterizing, components, isotopes, facilitated, chromatographically
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Streamlining characterization and monitoring of oligonucleotide impurities using an Orbitrap-based LC-HRAM-MS platform
2022|Thermo Fisher Scientific|Applications
Application note | 001398 Biopharma Streamlining characterization and monitoring of oligonucleotide impurities using an Orbitrap-based LC-HRAM-MS platform Application benefits Authors Hao Yang , Keeley Murphy , Yi Zhang , 1 2 3 • Comprehensive characterization of oligonucleotides and their impurities…
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oligonucleotide, oligonucleotideflp, flporbitrap, orbitrapexploris, explorisimpurities, impuritiesrna, rnaimpurity, impuritymass, massvanquish, vanquisheworkflow, eworkflowfull, fullchromeleon, chromeleonsequence, sequencecharacterization, characterizationrelative
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Application note | 000463 Biopharma The MAM 2.0 workflow enables seamless transition from research and development to quality control Authors Application benefits Hao Yang, Melissa Sato, Royston 1 1 • A MAM method developed on the Thermo Scientific™ Orbitrap Exploris™…
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mam, mamexploris, explorisnistmab, nistmaborbitrap, orbitrappqas, pqaspqa, pqapeptide, peptideeworkflow, eworkflowmapping, mappingmass, massquality, qualitychromeleon, chromeleonmodification, modificationmethod, methodcomponent
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2020|Thermo Fisher Scientific|Applications
APPLICATION NOTE 73870 Identification and quantitation of oligonucleotides, impurities, and degradation products Haichuan Liu1, Kevin Guo2, Jennifer Sutton1, Keeley Murphy1, Min Du2 1 Thermo Fisher Scientific, San Jose, CA 2 Thermo Fisher Scientific, Boston, MA Keywords: Oligonucleotide, RNA, impurity, purification,…
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oligonucleotide, oligonucleotideimpurities, impuritiesfinder, finderbiopharma, biopharmaabundance, abundancedesalting, desaltingagc, agcrelative, relativehplc, hplcvalue, valuesoftware, softwarednapac, dnapaccustom, customintensity, intensitymicroscans
Characterization of in vitro-transcribed (IVT) mRNA poly(A) tail by LC-HRAM-MS and BioPharma Finder 5.0 software
2022|Thermo Fisher Scientific|Applications
Application note | 001183 Biopharma Characterization of in vitro-transcribed (IVT) mRNA poly(A) tail by LC-HRAM-MS and BioPharma Finder 5.0 software Authors Application benefits Robert L. Ross1, Jenny England2, Rhonda • Confident identification and sequence confirmation of polyadenylated tails in synthetic…
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poly, polytail, tailfinder, finderbiopharma, biopharmapolyadenylated, polyadenylatedmass, massdeconvolution, deconvolutionmrna, mrnarelative, relativeabundance, abundancethermo, thermomonoisotopic, monoisotopicintact, intactonec, onecdeconvoluted