Streamlining characterization and monitoring of oligonucleotide impurities using an Orbitrap-based LC-HRAM-MS platform
Applications | 2022 | Thermo Fisher ScientificInstrumentation
LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap
IndustriesPharma & Biopharma
ManufacturerThermo Fisher Scientific
Key wordsoligonucleotide, flp, orbitrap, exploris, impurities, rna, impurity, vanquish, mass, eworkflow, full, chromeleon, sequence, characterization, relative, spectrometer, workbook, mau, charge, base, horizon, procedure, oligonucleotides, states, spectrum, sequences, arb, modifications, using, minutes, rsd, component, monoisotopic, created, hram, shown, detector, filter, uhplc, biotin, matching, coverage, exclusion, ion, methods, theoretical, resolution, deployment, quantitation, unmodified
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Streamlining workflow from characterization to monitoring of therapeutic oligonucleotides impurities across IPRP-LC-HRAM-MS platforms Hao Yang1; Keeley Murphy2; Jennifer Sutton1; Ken Cook3;Cheryl Rhodick3; Tufail Bashir3; Angela Criscuolo3; Tabiwang N. Arrey4; Catharina Crone4; Min Du2 1Thermo Fisher Scientific, San Jose, CA, United…
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oligonucleotide, oligonucleotidecharacterization, characterizationspet, spetimpurities, impuritiesexploris, explorisiprp, iprpidentified, identifiedorbitrap, orbitrapmonitoring, monitoringthermo, thermopredicted, predictedeworkflow, eworkflowscientific, scientificmetrics, metricsoligonucleotides
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APPLICATION NOTE 73789 Oligonucleotide mapping using BioPharma Finder software Authors: Haichuan Liu1, Kevin Guo2, Jennifer Sutton1, Min Du2 Thermo Fisher Scientific, San Jose, CA Thermo Fisher Scientific, Boston, MA 1 2 Keywords: Oligonucleotide, DNA, RNA, data dependent acquisition, tandem mass…
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pgd, pgdpad, padptd, ptdpcd, pcdptdpcd, ptdpcdoligonucleotides, oligonucleotidesoligonucleotide, oligonucleotidestepped, steppedpgr, pgrfinder, finderpur, purbiopharma, biopharmance, ncerelative, relativeintensity
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Application note | 000463 Biopharma The MAM 2.0 workflow enables seamless transition from research and development to quality control Authors Application benefits Hao Yang, Melissa Sato, Royston 1 1 • A MAM method developed on the Thermo Scientific™ Orbitrap Exploris™…
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mam, mamexploris, explorisnistmab, nistmaborbitrap, orbitrappqas, pqaspqa, pqapeptide, peptideeworkflow, eworkflowmass, massmapping, mappingquality, qualitychromeleon, chromeleonmodification, modificationcomponent, componentmethod
Identification and quantitation of oligonucleotides, impurities, and degradation products
2020|Thermo Fisher Scientific|Applications
APPLICATION NOTE 73870 Identification and quantitation of oligonucleotides, impurities, and degradation products Haichuan Liu1, Kevin Guo2, Jennifer Sutton1, Keeley Murphy1, Min Du2 1 Thermo Fisher Scientific, San Jose, CA 2 Thermo Fisher Scientific, Boston, MA Keywords: Oligonucleotide, RNA, impurity, purification,…
Key words
oligonucleotide, oligonucleotideimpurities, impuritiesfinder, finderbiopharma, biopharmaabundance, abundancedesalting, desaltingrelative, relativeagc, agchplc, hplcvalue, valuesoftware, softwarednapac, dnapaccustom, customintensity, intensitymicroscans