Characterization of a synthetic double stranded siRNA using high-resolution mass spectrometry
Applications | 2021 | Thermo Fisher ScientificInstrumentation
LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap
IndustriesPharma & Biopharma
ManufacturerThermo Fisher Scientific
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Oligonucleotide mapping using BioPharma Finder software
2020|Thermo Fisher Scientific|Applications
APPLICATION NOTE 73789 Oligonucleotide mapping using BioPharma Finder software Authors: Haichuan Liu1, Kevin Guo2, Jennifer Sutton1, Min Du2 Thermo Fisher Scientific, San Jose, CA Thermo Fisher Scientific, Boston, MA 1 2 Keywords: Oligonucleotide, DNA, RNA, data dependent acquisition, tandem mass…
Key words
pgd, pgdpad, padptd, ptdpcd, pcdptdpcd, ptdpcdoligonucleotides, oligonucleotidesoligonucleotide, oligonucleotidestepped, steppedpgr, pgrfinder, finderpur, purbiopharma, biopharmance, ncerelative, relativeintensity
High Resolution LC/MS Analysis of Therapeutic Oligonucleotides on a New Porous Polymer-Based Reversed Phase Column
2016|Thermo Fisher Scientific|Applications
0 Introduction 100 80 Relative Abundance Synthetic ONs with different functionalities including antisense ONs, small interfering RNAs (siRNAs), aptamers and immunostimulatory RNAs (isRNAs) are candidate therapeutic agents due to their specificity, and well-established synthesis and modification technologies. Still characterization is…
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abundance, abundancerelative, relativesirnas, sirnasmeoa, meoameou, meoucpg, cpgmethylated, methylatedphosphorothioate, phosphorothioateexactive, exactivesequences, sequencesabsorbance, absorbanceons, onsmau, maumodified, modifiedagcugacccugaag
Efficient Method Development of Small Interfering RNA by Reversed-Phase Ion-Pair Chromatograph
2023|Shimadzu|Posters
Efficient Method Development of Small Interfering RNA by Reversed-Phase Ion-Pair Chromatography Daiki 1 Fujimura , Yusuke 1 Osaka 1Shimadzu , Corporation Chromatograms measured under the concentration of HFIP (100 and 200 mmol/L) are shown in Fig.5. The result shows that…
Key words
antisense, antisensescepter, scepterdipea, dipeamau, maushim, shimpack, packsence, sencemmol, mmolclaris, clarisstrand, strandline, lineimpurity, impurityshifted, shiftedoptimal, optimaldaiki
Streamlining characterization and monitoring of oligonucleotide impurities using an Orbitrap-based LC-HRAM-MS platform
2022|Thermo Fisher Scientific|Applications
Application note | 001398 Biopharma Streamlining characterization and monitoring of oligonucleotide impurities using an Orbitrap-based LC-HRAM-MS platform Application benefits Authors Hao Yang , Keeley Murphy , Yi Zhang , 1 2 3 • Comprehensive characterization of oligonucleotides and their impurities…
Key words
oligonucleotide, oligonucleotideflp, flporbitrap, orbitrapexploris, explorisimpurities, impuritiesrna, rnaimpurity, impurityvanquish, vanquishmass, masseworkflow, eworkflowfull, fullchromeleon, chromeleonsequence, sequencecharacterization, characterizationrelative