Complete characterization of a lysine-linked antibody drug conjugate by native LC/MS intact mass analysis and peptide mapping
Applications | 2017 | Thermo Fisher ScientificInstrumentation
LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap
IndustriesPharma & Biopharma
ManufacturerThermo Fisher Scientific
Key wordschain, heavy, peptide, adc, mass, intact, native, setting, mapping, conjugation, drug, emtansine, linker, antibody, light, lysine, modifications, trastuzumab, side, biopharma, max, parameters, conjugated, protein, linked, sliding, source, range, separation, variable, file, resolution, kvepk, width, isoforms, dar, tolerance, conjugate, threshold, denaturing, cho, approaches, high, target, scientific, mixtures, hmr, mcc, mode, probe
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linker, linkerkvepk, kvepkpeptide, peptidenative, nativeintact, intactdrug, drugmcc, mccemtansine, emtansineadc, adcmass, massmapping, mappingtrastuzumab, trastuzumabantibody, antibodyspectra, spectraforms
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adcs, adcsdeconvoluted, deconvolutedadc, adctrastuzumab, trastuzumabdeglycosylated, deglycosylatedmass, masscounts, countsdrug, drugantibody, antibodysec, seclinker, linkerspectrum, spectrumcharge, chargedar, darconjugates
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trastuzumab, trastuzumabadcs, adcsadc, adcdeconvoluted, deconvolutedemtansine, emtansinecounts, countsdrug, drugdeglycosylated, deglycosylatedamu, amumass, masssec, secmabs, mabsbuffer, bufferspectrum, spectrumantibody
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dar, daradc, adcbruker, brukermaxis, maxisdrug, drugantibody, antibodylinker, linkerconjugation, conjugationaverage, averagemab, mabglycoforms, glycoformsdenaturing, denaturingconjugated, conjugatedpotency, potencyinterchain