Analysis of Antibody-Drug Conjugates Using Size Exclusion Chromatography and Mass Spectrometry
Applications | 2017 | Agilent TechnologiesInstrumentation
LC/TOF, LC/HRMS, LC/MS, LC/MS/MS, GPC/SEC
IndustriesPharma & Biopharma
ManufacturerAgilent Technologies
Key wordstrastuzumab, adcs, adc, deconvoluted, emtansine, counts, drug, deglycosylated, amu, sec, mass, mabs, buffer, spectrum, antibody, exclusion, using, charge, assigned, cytotoxic, entropy, antibodies, bin, linker, mab, linked, din, intact, dar, pbs, potent, loading, tris, size, conjugates, comprising, distribution, species, peaks, characterization, glycosylation, intense, due, lysine, temperature, chromatography, maytansine, arrest, revealed, agilent
Similar PDF
Size Exclusion Chromatography/ Mass Spectrometry Analysis of Antibody Drug Conjugates Using the Agilent 1260 Infinity II Bio-Inert LC
2016|Agilent Technologies|Applications
Size Exclusion Chromatography/ Mass Spectrometry Analysis of Antibody Drug Conjugates Using the Agilent 1260 Infinity II Bio-Inert LC Application Note Biologics & Biosimilars Author Abstract Sonja Schneider Recombinant monoclonal antibodies (mAbs) have emerged as important Agilent Technologies, Inc. therapeutic agents…
Key words
adcs, adcsdeconvoluted, deconvolutedadc, adctrastuzumab, trastuzumabdeglycosylated, deglycosylatedmass, masscounts, countsdrug, drugantibody, antibodysec, seclinker, linkerspectrum, spectrumdar, darcharge, chargeconjugates
A streamlined drug-to-antibody ratio determination workflow for intact and deglycosylated antibody-drug conjugates
2019|Agilent Technologies|Applications
Application Note Pharma and Biopharma A streamlined drug-to-antibody ratio determination workflow for intact and deglycosylated antibody-drug conjugates Using the Agilent AssayMAP Bravo and Agilent 6545XT AdvanceBio accurate-mass quadrupole time-of-flight LC/MS system Authors Jerry Han, Zach Van Den Heuvel, and Steve…
Key words
deglycosylation, deglycosylationaffinity, affinityassaymap, assaymapadc, adcdar, darcartridges, cartridgesadcs, adcscartridge, cartridgestreptavidin, streptavidinpurified, purifiedserum, serumantibody, antibodywere, werepurification, purificationsulfo
SEC Coupled to High-Resolution Mass Spectrometry for Detailed Characterization of mAbs and ADCs
2018|Agilent Technologies|Applications
Application Note Biologics SEC Coupled to High-Resolution Mass Spectrometry for Detailed Characterization of mAbs and ADCs Authors Isabel Vandenheede, Lucie Jorge, Pat Sandra, and Koen Sandra Research Institute for Chromatography (RIC) President Kennedypark 26 B-8500 Kortrijk Linda Lloyd, Anne Blackwell,…
Key words
deconvoluted, deconvolutedamu, amucounts, countssec, secidez, idezresponse, responsemass, massadcs, adcsmabs, mabsacquisition, acquisitionherceptin, herceptinfucose, fucoseunits, unitsmab, mabmannose
Sensitive Native Mass Spectrometry of Macromolecules Using Standard Flow LC/MS
2020|Agilent Technologies|Applications
Application Note Pharma & Biopharma Sensitive Native Mass Spectrometry of Macromolecules Using Standard Flow LC/MS Author David L. Wong Agilent Technologies, Inc. Abstract Native mass spectrometry can be used for a variety of protein-based applications, such as protein-protein interaction, protein-ligand…
Key words
native, nativeprotein, proteincounts, countsintact, intactdeconvoluted, deconvolutedamu, amumyoglobin, myoglobinmass, massapomyoglobin, apomyoglobincharge, chargeheme, hemecomplexes, complexesholomyoglobin, holomyoglobintetramer, tetramerdenatured