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Characterization of mRNA 5’ capping products using an LC-HRAM-MS/MS analytical platform and Thermo Scientific BioPharma Finder software solution

Applications | 2022 | Thermo Fisher ScientificInstrumentation
Software, LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap
Industries
Pharma & Biopharma
Manufacturer
Thermo Fisher Scientific
Key words
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Application note | 001183 Biopharma Characterization of in vitro-transcribed (IVT) mRNA poly(A) tail by LC-HRAM-MS and BioPharma Finder 5.0 software Authors Application benefits Robert L. Ross1, Jenny England2, Rhonda • Confident identification and sequence confirmation of polyadenylated tails in synthetic…
Key words
poly, polytail, tailfinder, finderbiopharma, biopharmapolyadenylated, polyadenylatedmass, massdeconvolution, deconvolutionmrna, mrnarelative, relativeabundance, abundancethermo, thermomonoisotopic, monoisotopicintact, intactonec, onecdeconvoluted
Customer application note | 000723 Biotechnology mRNA direct sequence mapping using automated partial digestion with magnetic nuclease and LC-HRMS Authors Application benefits Mark Dickman1, Christina Vanhinsbergh1, Jon Bardsley , Ken Cook , Andrew 2 2 Williamson2, Jennifer Sutton3, Keeley Murphy3…
Key words
mrna, mrnasequence, sequenceegfp, egfpintensity, intensitytimeretention, timeretentiondigestion, digestionrna, rnarelative, relativefragments, fragmentsunmodified, unmodifiedmapping, mappingpartial, partialoligonucleotide, oligonucleotidemodified, modifiedoligoribonucleotide
Application note | 002601 Biopharma Confident intact mass analysis of the tRNA isodecoders of phenylalanine by UHPLC-HRAM-MS and BioPharma Finder software Application benefits Authors Robert L. Ross1, Keeley Murphy1, • Confident and sensitive identification of biological transfer ribonucleic acid (tRNA)…
Key words
trnaphe, trnaphefinder, findermass, massintact, intacttrna, trnathermo, thermobiopharma, biopharmascientific, scientifictribrid, tribridascend, ascendisodecoders, isodecodershram, hramorbitrap, orbitrapvanquish, vanquishdibutylamine
Characterization of mRNA vaccine 5’ and 3’ end products using BioPharma Finder 5.0 Robert L Ross, Qian Qi, Keeley Murphy, Min Du, Thermo Fisher Scientific, Waltham, MA ABSTRACT Data Analysis 5’ Capping We sought the development of a Thermo Scientific™…
Key words
fragmentation, fragmentationpoly, polynucleases, nucleasesdeconvoluted, deconvolutediprp, iprpsequence, sequencelength, lengthmrna, mrnacolleagues, colleaguesmsms, msmsannotated, annotatedtail, tailcoded, codedrepresentation, representationfeedback
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