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ISC: Oligonucleotide sequencing by LC-MS/MS

Presentations | 2022 | Thermo Fisher ScientificInstrumentation
LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap
Industries
Pharma & Biopharma
Manufacturer
Thermo Fisher Scientific
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Customer application note | 000723 Biotechnology mRNA direct sequence mapping using automated partial digestion with magnetic nuclease and LC-HRMS Authors Application benefits Mark Dickman1, Christina Vanhinsbergh1, Jon Bardsley , Ken Cook , Andrew 2 2 Williamson2, Jennifer Sutton3, Keeley Murphy3…
Key words
mrna, mrnasequence, sequenceegfp, egfptimeretention, timeretentionintensity, intensitydigestion, digestionrna, rnarelative, relativefragments, fragmentsmapping, mappingunmodified, unmodifiedpartial, partialoligonucleotide, oligonucleotidemodified, modifiedoligoribonucleotide
Myth busting: “You cannot sequence oligonucleotides over 20 to 30 nucleotides long by LCMS/MS” Learn how to routinely sequence 100 nt oligonucleotides Alexander Schwahn1, Ulrik Mistarz2, Keeley Murphy3, and Ken Cook4; Thermo Fisher Scientific: 1) Reinach, Switzerland; 2) Copenhagen, Denmark;…
Key words
oligonucleotides, oligonucleotidessequence, sequencesequencing, sequencingtherapeutics, therapeuticsfragmentation, fragmentationmrna, mrnalarge, largeoligonucleotide, oligonucleotidestates, stateslong, longexploris, explorisfinder, findercharge, chargepromote, promotewhich
Application note | 001108 Biopharma Characterization of mRNA 5’ capping products using an LC-HRAM-MS/MS analytical platform and Thermo Scientific BioPharma Finder software solution Authors Goal Robert L Ross, Keeley Murphy, Yi Zhang, To develop a sensitive and robust LC-HRAM-MS/MS method…
Key words
decapped, decappedcapped, cappedrnase, rnasedigestion, digestionabundance, abundancethermo, thermorelative, relativemrna, mrnascientific, scientificscan, scandependent, dependentonec, onecbiopharma, biopharmadata, datavanquish
BioPharma workflow solutions
2022|Thermo Fisher Scientific|Brochures and specifications
BioPharma Chromatography columns and consumables BioPharma workflow solutions Complete biopharma workflow solutions For scientists pursuing robust and reproducible methods when and reproducible methods with great results despite working working with biopharmaceuticals, selecting the correct workflow with complex samples. The workflows…
Key words
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