Myth busting: “You cannot sequence oligonucleotides over 20 to 30 nucleotides long by LCMS/MS” Learn how to routinely sequence 100 nt oligonucleotides
Posters | 2023 | Thermo Fisher Scientific | HPLC SymposiumInstrumentation
LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap
IndustriesPharma & Biopharma
ManufacturerThermo Fisher Scientific
Key wordsoligonucleotides, sequence, sequencing, therapeutics, fragmentation, mrna, large, oligonucleotide, states, long, exploris, finder, charge, promote, which, energies, new, biopharma, resent, mapping, coverage, high, fragments, developed, orbitrap, higher, scientific, asr, annotates, intrinsically, fisher, previously, trademarks, sequenced, mass, resolution, were, optimization, characterization, fully, nucleotide, used, software, nucleotides, energy, results, chromatography, optimized, broken, size
Similar PDF
ISC: Oligonucleotide sequencing by LC-MS/MS
2022|Thermo Fisher Scientific|Presentations
Oligonucleotide sequencing by LC-MS/MS: A novel Approach for Characterization and Quality Control of mRNA-based Vaccines and Biotherapeutics Alexander Schwahn, Angela Criscuolo, and Ken Cook The world leader in serving science 1 [email protected] | ISC2022 Why have oligonucleotides become so popular?…
Key words
mrna, mrnarna, rnaasr, asrnce, nceprotein, proteindigestion, digestionsequencing, sequencingstepped, steppedoligonucleotide, oligonucleotidethermo, thermotiv, tivvaccine, vaccinescientific, scientificcoat, coatgagc
mRNA direct sequence mapping using automated partial digestion with magnetic nuclease and LC-HRMS
2022|Thermo Fisher Scientific|Applications
Customer application note | 000723 Biotechnology mRNA direct sequence mapping using automated partial digestion with magnetic nuclease and LC-HRMS Authors Application benefits Mark Dickman1, Christina Vanhinsbergh1, Jon Bardsley , Ken Cook , Andrew 2 2 Williamson2, Jennifer Sutton3, Keeley Murphy3…
Key words
mrna, mrnasequence, sequenceegfp, egfpintensity, intensitytimeretention, timeretentiondigestion, digestionrna, rnarelative, relativefragments, fragmentsunmodified, unmodifiedmapping, mappingpartial, partialoligonucleotide, oligonucleotidemodified, modifiedoligoribonucleotide
Oligonucleotide mapping using BioPharma Finder software
2020|Thermo Fisher Scientific|Applications
APPLICATION NOTE 73789 Oligonucleotide mapping using BioPharma Finder software Authors: Haichuan Liu1, Kevin Guo2, Jennifer Sutton1, Min Du2 Thermo Fisher Scientific, San Jose, CA Thermo Fisher Scientific, Boston, MA 1 2 Keywords: Oligonucleotide, DNA, RNA, data dependent acquisition, tandem mass…
Key words
pgd, pgdpad, padptd, ptdpcd, pcdptdpcd, ptdpcdoligonucleotides, oligonucleotidesoligonucleotide, oligonucleotidestepped, steppedfinder, finderpgr, pgrbiopharma, biopharmapur, purnce, ncerelative, relativeintensity
Identification and quantitation of oligonucleotides, impurities, and degradation products
2020|Thermo Fisher Scientific|Applications
APPLICATION NOTE 73870 Identification and quantitation of oligonucleotides, impurities, and degradation products Haichuan Liu1, Kevin Guo2, Jennifer Sutton1, Keeley Murphy1, Min Du2 1 Thermo Fisher Scientific, San Jose, CA 2 Thermo Fisher Scientific, Boston, MA Keywords: Oligonucleotide, RNA, impurity, purification,…
Key words
oligonucleotide, oligonucleotideimpurities, impuritiesfinder, finderbiopharma, biopharmaabundance, abundancedesalting, desaltingagc, agcrelative, relativehplc, hplcvalue, valuesoftware, softwarednapac, dnapacmicroscans, microscanscustom, customintensity