Metrohm 907 Titrando

Importance of the Topic

Volumetric titration remains a fundamental technique in analytical chemistry, providing accurate quantification of a wide range of analytes. The modular Titrando series by Metrohm enhances this classic approach through automation, flexible sensor integration and digital control. These advancements improve result consistency, reduce manual intervention and enable more efficient laboratory workflows, making the technique highly relevant for research, quality control and industrial analytics.

Study Objectives and Overview

This manual documents the features, setup and operation of the 907 Titrando, the core controller in Metrohm’s modular titration platform. It aims to guide users through the installation of peripheral devices, connection of electrodes and sensors, selection of titration and measuring modes, and routine maintenance. The text also describes Karl Fischer titration workflows for water determination and outlines safety and troubleshooting measures.

Methodology and Instrumentation

The 907 Titrando controller can be operated with a touch-sensitive handheld “Touch Control” or via PC software (e.g., tiamo™). It offers:

• Four MSB (Metrohm Serial Bus) ports for Dosino/Dosimat burettes, stirrers or remote boxes.
• Two USB downstream ports for printers, keyboards or barcode readers.
• One USB upstream port for the Touch Control or PC.
• One or two galvanically isolated measuring interfaces supporting potentiometric, amperometric (Upol), voltametric (Ipol) and temperature measurements.

Peripheral devices and sensors connect via standardized cables and connectors. The instrument supports DET, MET, SET, STAT, KFT and STAT titration modes and includes commands for dosing, priming and emptying burettes. In Karl Fischer titration, a dedicated cell with molecular sieve adsorber, double-platinum electrodes and methanolic reagents performs accurate water content determinations.

Main Results and Discussion

Integration of dosing, stirring and sensing units via MSB ensures rapid system configuration and automatic device recognition. USB connectivity facilitates data transfer, remote printing and keyboard input. The potentiometric and amperometric measuring interfaces offer high input impedance (>10¹² Ω) and precise control of polarization currents (±125 μA) or voltages (±1,250 mV). Temperature compensation is handled by Pt1000 or NTC sensors. Karl Fischer titrations achieve stable drifts below 10 μL/min, enabling reproducible water determinations across 0.1–100% content.

Benefits and Practical Applications

• Full automation of titration sequences reduces manual steps and error rates.
• Modular design allows laboratories to expand functionality by adding burettes, stirrers and remote switches.
• High-resolution measurements support complex titrations such as acid–base, redox, complexometric and Karl Fischer analyses.
• Standardized interfaces and user-friendly software accelerate instrument qualification and method development.
• Suitable for R&D, QA/QC and high-throughput industrial analytics.

Future Trends and Opportunities

Next-generation titration platforms will likely embrace cloud-based data management, artificial intelligence–driven endpoint detection and real-time quality checks. Miniaturization of titration cells and integration with lab-on-a-chip technologies may reduce reagent consumption and enable in-line process monitoring. Enhanced sensor chemistries and smart electrodes with digital data chips will further improve reliability and streamline method transfer across laboratories.

Conclusion

The Metrohm 907 Titrando exemplifies modern analytical instrumentation by combining robust hardware, modular expandability and precise digital control. It streamlines a wide range of titration methods—including Karl Fischer water determination—while ensuring data integrity and repeatability. Its flexible architecture positions it as a versatile solution for academic, regulatory and industrial laboratories.

Instrumentation Used

• 907 Titrando controller
• 900 Touch Control or PC with tiamo™ software
• Dosino/Dosimat burettes
• 801 Magnetic stirrer or 804 Titration stand with rod stirrer
• 854 iConnect interface for digital electrodes
• pH, reference and temperature sensors (Pt1000/NTC)
• Double-platinum bridge electrodes for Karl Fischer titration
• Custom Karl Fischer titration cell with molecular sieve adsorber