Metrohm 906 Titrando

Importance of the topic

The 906 Titrando represents a modern modular approach to automated titration combining flexibility with precise control.
Potentiometric and coulometric titration methods including Karl Fischer water determination are critical in quality control across chemical, pharmaceutical and industrial sectors.
Reliable automation reduces manual intervention, enhances reproducibility and supports high throughput while meeting stringent regulatory standards.

Objectives and overview

This manual introduces the installation, operation and maintenance of the Metrohm 906 Titrando system.
It covers hardware setup, software control via Touch Control or PC, peripheral connection through MSB and USB, and comprehensive titration workflows.
Key goals include guiding users through safe instrument configuration, optimizing titration parameters and ensuring robust performance for various analytical applications.

Methodology and used instrumentation

The Titrando system comprises:

• 906 Titrando titration device with galvanically isolated measurement interface
• Touch Control module or PC software (e.g. tiamo) for method programming and data acquisition
• MSB bus connectors to integrate Dosino/Dosimat dosing units, magnetic stirrers, titration stands and Remote Box modules
• USB ports for printers, keyboards, barcode readers and external processing units
• Exchange units with data-chip for internal dosing drive management and reagent tracking
• Measurement interfaces for pH, ion-selective, reference and polarizable electrodes, temperature sensors (Pt1000/NTC) and iTrodes via the 854 iConnect
• Karl Fischer titration cell complete with vessel lid, buret and aspiration tips, adsorber tube and molecular sieve for volumetric water determination

The manual details sensor connections, programming of titration modes (DET, MET, SET, STAT, KFT), and guidelines for electrode calibration and cleaning.

Main results and discussion

The 906 Titrando achieves precise dosing with 1–50 mL exchange units and up to 20 000 piston steps.
Galvanic isolation ensures low-noise potentiometric and voltammetric measurements with <0.003 pH and 0.2 mV accuracy under reference conditions.
Karl Fischer titrations benefit from biamperometric and bivoltammetric endpoints and drift compensation down to <10 µL/min.
Integrated data-chip tracking simplifies reagent management and method reproducibility.
Versatile periphery integration streamlines multi-sample workflows and supports automated routines from standard addition to differential potentiometry.

Benefits and practical applications

• High accuracy and reproducibility for water content analysis, acid-base, redox and ion-selective titrations
• Flexible system architecture allows tailored configurations for research, manufacturing and QA/QC environments
• Automated dosing and data acquisition minimize operator error and support compliance with GLP/GMP standards
• Comprehensive peripheral integration (balances, printers, barcode readers) enhances lab efficiency and traceability

Future trends and potential developments

Integration with laboratory robotics and sample processors will expand throughput and system autonomy.
Enhanced remote control and cloud connectivity can facilitate real-time data monitoring and predictive maintenance.
Advances in sensor technology and chip-based electrodes (iTrodes) will improve measurement stability and offer plug-and-play convenience.
Development of miniaturized and inline titration modules could support continuous process analysis in flow chemistry.

Conclusion

The Metrohm 906 Titrando manual provides a comprehensive guide to setting up, operating and maintaining a state-of-the-art titration platform.
Its modular design, precise measurement capabilities and extensive peripheral connectivity make it a powerful tool for a wide range of analytical titration applications.
Adherence to the described procedures and maintenance routines ensures reliable performance and long-term instrument stability.

References

No external references were cited in this summary.