904/905 and 906/907 Titrando

Importance of the Topic

Modern titration laboratories require flexible and intelligent instruments to ensure precise, compliant and high-throughput analyses. The growing complexity of pharmaceutical, food and environmental testing demands reliable titrators capable of automatic dosing, digital data handling and full traceability under GLP/GMP and FDA regulations.

Objectives and Study Overview

This application note presents the Metrohm Titrando 904/905 and 906/907 series of intelligent potentiometric titrators. It describes system architecture, key modules, analytical modes (potentiometric, Karl Fischer and STAT titrations) and software integration for sample handling and data management. The goal is to highlight how modular hardware and smart sensors streamline routine and advanced titrations.

Methodology and Instrumentation

The Titrando system is based on a modular platform with:

• Built-in buret drive with analog/digital measuring input (904/906) or external (905/907)
• Dosino (800) and Dosimat (805) dosing elements mounted on reagent bottles
• Exchange Unit (806) and Dosing Unit (807) featuring Data Chips for automatic reagent identification and titer reading
• Intelligent electrodes (iTrodes) with 854 iConnect measuring input for digital signal transmission and automatic recognition
• Stirrers (801 magnetic, 802 rod) and KF titration stand (803) for Karl Fischer applications
• 900 Touch Control for intuitive operation and network connectivity (USB, Ethernet, Bluetooth)
• tiamo software for advanced method editing, automation (sample processors 814/815, XYZ 898), database management and LIMS integration

Main Results and Discussion

The Titrando series achieves high dosing resolution (up to 20 000 steps per cylinder), parallel titration of two samples, and seamless switching during reagent refill (tandem dosing). Digital data chips eliminate mix-ups by storing titrant and sensor metadata (titer, lifetime, calibration history). Automating electrode tests and plausibility checks enhances result reliability. The 900 Touch Control interface accelerates method start via favorites, generates PDF reports autonomously, and accesses intranet resources. Integration with tiamo software enables client-server databases, audit trails (21 CFR Part 11 compliance) and flexible report generation.

Benefits and Practical Applications

Key advantages include:

• Enhanced traceability and compliance with GLP/GMP
• Reduction of bench space through on-bottle dosing units
• Predefined methods and templates for rapid deployment
• High throughput via sample changer automation and parallel titration
• Robust digital communication minimizing electrical noise
• Scalable configuration to match diverse analytical needs

Future Trends and Potential Applications

Further developments may integrate cloud-based data analytics and AI-driven titration optimizations. Expansion of IoT connectivity will enable remote monitoring and automated notifications. Smart sensors could support broader analyte detection (e.g., multi-parameter probes) and real-time quality assurance across distributed laboratories.

Conclusion

The Metrohm Titrando 904/905 and 906/907 series represent a significant advance in modern titration workflows. By combining modular hardware, intelligent dosing and sensors, and comprehensive software, the system delivers precise, compliant and highly automated titrations for a wide range of applications.

References

• Metrohm AG. Intelligent potentiometric titrators: Titrando 904/905 and 906/907. Application Note 8.904.5001EN; Herisau, Switzerland; 2013.