Chromeleon 7.3 - List of Supported Instruments

Importance of the topic

The integration of chromatography and mass spectrometry systems into a unified data management platform like Chromeleon 7 is critical for ensuring reliable instrument control, accurate data acquisition and efficient regulatory compliance. A comprehensive compatibility matrix minimizes downtime and supports seamless workflows across diverse analytical laboratories.

Goals and overview

This document presents a detailed catalog of all instruments supported by Chromeleon 7. It specifies manufacturers, device families and models, required firmware versions, communication interfaces, license classes, optional modules, minimum software releases, supported Windows operating systems and compatibility with the Thermo Fisher 247 Instrument Controller.

Methodology and instrumentation

Support is organized by tabular entries that include:

• Manufacturer and system/family name
• Device type (e.g., pump, detector, autosampler, mass spectrometer)
• Model number and minimum firmware
• Interface type (USB, LAN, RS232 or analog/digital converters)
• Instrument license class and optional feature licenses (3D data, GC-MS, LC-MS, fraction collection)
• Required Chromeleon version and any service releases or maintenance updates
• Supported Windows editions (Windows 8.1, Windows 10) and 247 controller firmware

Obsolete drivers and third-party vendor solutions are also listed, with notes on driver signing and external interfaces for analog data acquisition.

Použitá instrumentace

• Thermo Scientific Dionex IC and dual-pump systems (ICS series, Integrion, Aquion)
• Thermo Scientific UltiMate 3000 LC pumps, autosamplers and detectors
• Thermo Scientific TriPlus headspace and liquid autosamplers
• Agilent, Shimadzu, PerkinElmer, Waters, Gilson, ISCO, Varian, Bruker, Markes thermal desorbers and more
• Mass spectrometers: ISQ, TSQ, MSQ Plus, Orbitrap Exactive and Exploris
• Analog-to-digital interfaces (UCI, A2D) and fraction collectors
• Obsolete Chromeleon drivers and certified third-party drivers (e.g., Agilent, Shimadzu, Knauer)

Key results and discussion

Chromeleon 7 supports hundreds of chromatographic and spectrometric devices, covering a wide spectrum of hardware generations. By specifying exact firmware, driver versions, licensing requirements and cabling details, the list enables integrators to deploy complete instrumentation suites with confidence. Obsolete driver sections facilitate legacy system support, while third-party listings encourage extensions through certified solutions.

Benefits and practical application

• Unified control of diverse instruments within a single CDS
• Clear versioning and licensing guidance to prevent configuration errors
• Streamlined compliance through validated hardware-software combinations
• Reduced need for multiple software packages and custom integrations

Future trends and potential uses

• Ongoing expansion to cover new chromatography and MS platforms
• Enhanced cloud connectivity and AI-driven method development
• Deeper automation of calibration and compliant tuning in sequences
• Broader adoption of signed third-party drivers on secured controllers

Conclusion

The Chromeleon 7 instrument compatibility list offers a comprehensive reference for laboratories seeking to integrate a wide variety of chromatographic and mass spectrometric hardware. By consolidating firmware, driver, interface and licensing requirements, Thermo Fisher Scientific enables efficient, reliable and compliant data acquisition across multiple platforms.

Reference

List of Supported Instruments, Chromeleon 7.3, Document Revision 2.0, May 2020, Thermo Fisher Scientific