Agilent 1200 Infinity Series Universal Interface Box

Importance of the Topic

The efficient integration of chromatography modules and external detectors is critical to advanced HPLC workflows. The Agilent 1200 Infinity Series Universal Interface Box II (UIB II) addresses growing demands for analog and digital connectivity, automated fraction collection, and enhanced laboratory safety, enabling seamless communication between Agilent LC modules and third-party devices.

Aims and Overview

This document summarizes the design, functionality, and deployment options of the UIB II accessory. It explains how the module extends instrument communication capabilities for analog/digital signals and supports peak-based or mass-based fraction collection in complex analytical setups.

Methodology and Instrumentation

The UIB II serves as a multipurpose interface offering:

• Analog input (–1 V to 1 V) with 24-bit A/D conversion for third-party detectors.
• Analog output to export pressure or detector traces to external data systems.
• General Purpose I/O (GPIO/Enhanced Remote Interface) with eight programmable I/O lines, 5 V/24 V power, and 1-wire data bus.
• Four programmable relay contacts for timed switching of peripheral equipment.
• External leak sensor input, CAN bus for module synchronization, and wide-range AC power supply.

Main Results and Discussion

The module’s flexible cable options support various connection schemes for analog out, analog in, peak-triggered fraction collection, and mass-based fraction triggers with Agilent MS. Configuration dip-switches enable standard, resident, or forced cold-start modes, ensuring robust firmware management and quick recovery from errors.

Benefits and Practical Applications

UIB II enhances automation in QA/QC labs and research environments by allowing:

• Real-time capture of external detector signals within the chromatography data system.
• Automated fraction collection based on defined thresholds or mass triggers.
• Improved safety through external leak detection and controlled relay outputs.
• Scalable connectivity for emerging sensor technologies.

Future Trends and Potential Applications

As analytical workflows evolve, future developments may include cloud-integrated monitoring, AI-driven peak recognition, seamless IoT sensor integration, and higher-throughput fractionation capabilities. The UIB II platform can adapt to these trends via firmware updates and expanding add-on modules.

Conclusion

The Agilent 1200 Infinity Series Universal Interface Box II is a versatile module that bridges Agilent LC systems with diverse external devices. Its analog/digital I/O, programmable relays, and safety features deliver enhanced automation, data integrity, and operational flexibility.

Reference

• Agilent Technologies. Agilent 1200 Infinity Series Universal Interface Box II User Manual (G1390-90011), Edition 02/2013.