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CERM: CONSIDERATIONS FOR DEVELOPING A GREENER CHROMATOGRAPHIC METHOD

 

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Application Note Greener, Lower Cost Organic Mobile Phase Solvents for the LC-MS Analysis of Intact Biotherapeutic Proteins Henry Shion, Ying Qing Yu Waters Corporation Abstract This application note presents on the recent trend replacing acetonitrile (Class II Toxicity) with greener…
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Guide to Size-Exclusion Chromatography (SEC) of mAb Aggregates, Monomers, and Fragments 1 Table of Contents I. Introduction II. Importance of Developing a Robust LC-based SEC Method a. Choosing the Appropriate Protein BEH SEC Column b. Method Development III. Considerations When…
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[ APPLICATION NOTEBOOK ] IMPURITIES Developing Safe and Effective Drugs INT RODUCTION NAVIGATION T he pharmaceutical industry is integral in maintaining public health by providing therapeutic and preventative medicines. T he cornerstones of bringing new medicines to market are quality,…
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ApplicAtion SolutionS for BiophArmAceuticAlS A Focus on Protein Therapeutics Introduction: Key Challenges in Biopharmaceutical Characterization .............................................................................................5 7 PROTEIN mass aNalysIs comprehensive and routine characterization of proteins and peptides by lc/mS and lc/mS e ...............................................................9 characterization of an igG1 monoclonal Antibody…
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