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Aggregate Analysis of Adeno-Associated Viruses and Virus-Like Particles in Biopharma by Liquid Chromatography

 

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Consumables Workflow Ordering Guide Adeno-Associated Virus Identity Confirmation in Biopharma by LC/MS While adeno-associated viruses (AAVs) have their own unique set of critical quality attributes, many of the traditional assays used to monitor more established proteinbased therapeutics can still be…
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Consumables Workflow Ordering Guide Analyzing Monoclonal Antibody (mAb) Fragments and Dimers Using Size Exclusion Chromatography (SEC) Low molecular weight (LMW) fragments and high molecular weight (HMW) dimers and aggregates can be formed from biotherapeutic proteins during drug development, storage, shipment,…
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Consumables Workflow Ordering Guide Analyzing Monoclonal Antibody (mAbs) and mAb-Derived Therapeutics Using Native SEC-MS The quantitation of aggregates is of particular concern for protein-based-therapies given their potential effect on efficacy and immunogenicity. Size exclusion chromatography (SEC) combined with UV detection…
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Application Brief Biopharma/Pharma Resolution of Adeno-Associated Viral Vector Aggregates and Fragments with Agilent Bio SEC-5 Author Drs. Brian Liau, Anne Blackwell, and Matthew L. Turner Agilent Technologies, Inc. Introduction Adeno-associated viruses (AAVs) are a promising new class of biotherapeutic with…
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