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Impurity profiling of mycophenolate mofetil using an Orbitrap Exploris 120 mass spectrometer and Vanquish Horizon UHPLC combined with Compound Discoverer software

Applications | 2022 | Thermo Fisher ScientificInstrumentation
Software, LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap
Industries
Pharma & Biopharma
Manufacturer
Thermo Fisher Scientific
Key words
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Impurity Profiling Using Orbitrap Exploris 120 Mass Spectrometer and Vanquish UHPLC Coupled with Compound Discoverer Software Kate Comstock, Min Du Thermo Fisher Scientific, River Oaks Pkwy, San Jose, CA USA ABSTRACT Purpose: Combine the power of high-resolution MS with advanced…
Key words
mofetil, mofetilmycophenolate, mycophenolatevanquish, vanquishstructure, structureimpurity, impurityfragment, fragmentduty, dutyspectrum, spectrumapi, apilines, linesmolecule, moleculeprofiling, profilingcycle, cycleswitching, switchingunknown
APPLICATION NOTE 65953 Confident drug metabolite identification using an intelligent data acquisition and processing workflow Authors: Kate Comstock, Min Du, Thermo Fisher Scientific, San Jose, CA, USA; Min Jiang, Amgen, South San Francisco, CA, USA Keywords: High-Resolution Accurate Mass (HRAM),…
Key words
acquirex, acquirexexclusion, exclusionoxidation, oxidationmetabolite, metabolitetimolol, timololdda, ddainclusion, inclusionmetabolites, metabolitesvanquish, vanquishabundance, abundanceworkflow, workflowintelligent, intelligentdata, databackground, backgroundacquisition
Application note | 002455 Biotech Confident and sensitive profiling of lipid nanoparticle raw materials and impurity identification using a LC/CAD/HRAM-MS method with inverse gradient Authors Application benefits Sven Hackbusch , Sissi White , Min Du 1 2 2 • Confident…
Key words
chol, cholcad, cadmpeg, mpegµau, µauraw, rawvendor, vendorhram, hramdspe, dspelnp, lnpimpurity, impurityinverse, inverselipid, lipidchcl, chcldivert, divertthermo
Application note | 001949 Biotech LC/UV/HRAM MS-based impurity profiling and structure elucidation of phosphoramidite raw materials used for oligonucleotide synthesis Application benefits Authors Sven Hackbusch , Gary Held , Yi Zhang , 1 Min Du 2 3 • Sensitive detection…
Key words
dmt, dmtphosphoramidite, phosphoramiditeimpurities, impuritiescep, cepimpurity, impuritystructure, structureµau, µaudiscoverer, discovererdipa, dipacompound, compoundtransformation, transformationchlorination, chlorinationsubstitution, substitutionraw, rawdetection
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