Molecular Confirmation of Oligonucleotides Using Agilent LC/MSD XT and OpenLab CDS
Applications | 2024 | Agilent TechnologiesInstrumentation
LC/MS, LC/SQ
IndustriesPharma & Biopharma
ManufacturerAgilent Technologies
Key wordsoligonucleotides, mass, molecular, abundance, charge, oligonucleotide, ladder, spectrum, threshold, weight, msd, openlab, confirmation, deconvolution, cds, dna, accommodate, characterization, oligos, envelope, algorithm, synthetic, optimized, electrospray, relative, american, society, journal, assessing, unit, may, parameters, shortmer, longmer, poly, used, spectral, agilent, voltage, parameter, varying, rivera, calculated, bertram, thiolated, quadrupole, desorption, sheath, analysis, temperature
Similar PDF
Oligonucleotide Characterization by Agilent 1290 Infinity II Bio LC and 6545XT AdvanceBio LC/Q-TOF
2023|Agilent Technologies|Applications
Application Note Pharma & Biopharma Oligonucleotides Oligonucleotide Characterization by Agilent 1290 Infinity II Bio LC and 6545XT AdvanceBio LC/Q-TOF Oligonucleotide identity, impurities analysis and sequence determination using BioConfirm 12.0 target plus impurities (TPI) and sequence confirmation workflows Authors Introduction Bian…
Key words
oligonucleotide, oligonucleotideaso, asosequence, sequencetpi, tpicounts, countsacquisition, acquisitionconfirmation, confirmationoligonucleotides, oligonucleotidesworkflow, workflowcharge, chargeimpurities, impuritiesbioconfirm, bioconfirmmass, massagilent, agilentfluoro
High-throughput, Ion-Pairing-Free, HILIC Analysis of Oligonucleotides Using Agilent RapidFire Coupled to Quadrupole Time-of-Flight Mass Spectrometry
2022|Agilent Technologies|Applications
Application Note High-throughput, Ion-Pairing-Free, HILIC Analysis of Oligonucleotides Using Agilent RapidFire Coupled to Quadrupole Time-of-Flight Mass Spectrometry Author Abstract Peter Rye, PhD Agilent Technologies, Inc. This application note describes a high-throughput, ion-pairing-free method for oligonucleotide characterization using the Agilent RapidFire…
Key words
oligo, oligorapidfire, rapidfirecounts, countshilic, hilicoligos, oligosdeconvoluted, deconvolutedcharge, chargeamu, amumass, massiprp, iprpdepurination, depurinationpredominant, predominantwere, weredeconvolution, deconvolutionheights
Oligonucleotide Characterization by Bio LC and Q-TOF
2023|Agilent Technologies|Posters
Poster Reprint ASMS 2023 Poster number ThP 566 Oligonucleotide Characterization by Bio LC and Q-TOF Yulan Bian1, David L Wong2 1Agilent Technologies, Inc., Singapore 2Agilent Technologies, Inc., Santa Clara, CA Introduction Experimental Sample preparation Oligonucleotide (RNA) Resolution Standard was obtained…
Key words
oligonucleotide, oligonucleotidesequence, sequencetpi, tpioligonucleotides, oligonucleotidesconfirmation, confirmationimpurities, impuritiesworkflow, workflowmasshunter, masshunteravg, avgadvancebio, advancebiolength, lengthapta, aptaoerg, oergagilent, agilentbio
MS/MS Oligonucleotide Sequencing Using LC/Q-TOF with HILIC Chromatography
2023|Agilent Technologies|Applications
Application Note BioPharma MS/MS Oligonucleotide Sequencing Using LC/Q-TOF with HILIC Chromatography Authors Guannan Li and Peter Rye Agilent Technologies, Inc. Introduction Oligonucleotides are commonly analyzed by liquid chromatography/mass spectrometry (LC/MS) in negative ion polarity mode using ion-pairing reversed‑phase (IP‑RP) methods.…
Key words
charge, chargecounts, countsribose, riboseoligonucleotides, oligonucleotidesmass, masscollision, collisionhilic, hilicacquisition, acquisitionfragments, fragmentsoligo, oligosequence, sequencemultiple, multipleoligonucleotide, oligonucleotidespectrum, spectrumaptamer