Oligonucleotide Characterization by Agilent 1290 Infinity II Bio LC and 6545XT AdvanceBio LC/Q-TOF
Applications | 2023 | Agilent TechnologiesInstrumentation
LC/TOF, LC/HRMS, LC/MS, LC/MS/MS
IndustriesPharma & Biopharma
ManufacturerAgilent Technologies
Key wordsoligonucleotide, aso, sequence, tpi, counts, oligonucleotides, acquisition, confirmation, workflow, charge, impurities, bioconfirm, mass, agilent, fluoro, workflows, rna, advancebio, masshunter, time, tof, code, length, characterization, ribose, algorithm, oligo, ladder, synthetic, min, two, tic, avg, thermostat, species, were, annotation, targeted, truncates, parameters, jumhawan, udi, deconvoluted, quant, spectra, identity, optimized, rate, description, yulan
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Oligonucleotide Characterization by Bio LC and Q-TOF
2023|Agilent Technologies|Posters
Poster Reprint ASMS 2023 Poster number ThP 566 Oligonucleotide Characterization by Bio LC and Q-TOF Yulan Bian1, David L Wong2 1Agilent Technologies, Inc., Singapore 2Agilent Technologies, Inc., Santa Clara, CA Introduction Experimental Sample preparation Oligonucleotide (RNA) Resolution Standard was obtained…
Key words
oligonucleotide, oligonucleotidesequence, sequencetpi, tpioligonucleotides, oligonucleotidesconfirmation, confirmationimpurities, impuritiesworkflow, workflowmasshunter, masshunteravg, avgadvancebio, advancebiolength, lengthapta, aptaoerg, oergagilent, agilentbio
MS/MS Oligonucleotide Sequencing Using LC/Q-TOF with HILIC Chromatography
2023|Agilent Technologies|Applications
Application Note BioPharma MS/MS Oligonucleotide Sequencing Using LC/Q-TOF with HILIC Chromatography Authors Guannan Li and Peter Rye Agilent Technologies, Inc. Introduction Oligonucleotides are commonly analyzed by liquid chromatography/mass spectrometry (LC/MS) in negative ion polarity mode using ion-pairing reversed‑phase (IP‑RP) methods.…
Key words
charge, chargecounts, countsribose, riboseoligonucleotides, oligonucleotidesmass, masscollision, collisionhilic, hilicacquisition, acquisitionfragments, fragmentsoligo, oligosequence, sequencemultiple, multiplespectrum, spectrumoligonucleotide, oligonucleotideaptamer
Comprehensive and Integrated Workflow for Oligonucleotide Sequence Confirmation by Agilent High-Resolution LC/Q-TOF
2022|Agilent Technologies|Applications
Application Note Biopharma/Pharma Comprehensive and Integrated Workflow for Oligonucleotide Sequence Confirmation by Agilent High-Resolution LC/Q-TOF Robust and sensitive sequence confirmation of synthetic oligonucleotides and impurities Authors David L. Wong and Peter Rye Agilent Technologies, Inc. Abstract This application note demonstrates…
Key words
oligonucleotide, oligonucleotidesequence, sequenceoligonucleotides, oligonucleotidesconfirmation, confirmationcounts, countscharge, chargemass, massfragment, fragmentworkflow, workflowrna, rnaimpurities, impuritiessequences, sequencesladder, ladderdata, dataacquisition
An Integrated Workflow for the Analysis of Oligonucleotides and Their Impurities by Agilent High-Resolution LC/(Q-)TOF Mass Spectrometry
2022|Agilent Technologies|Applications
Application Note Biopharma/Pharma An Integrated Workflow for the Analysis of Oligonucleotides and Their Impurities by Agilent High-Resolution LC/(Q-)TOF Mass Spectrometry Separation, characterization, and relative quantitation of target oligonucleotides and their impurities Authors David L. Wong and Peter Rye Agilent Technologies,…
Key words
ttttt, tttttoligonucleotide, oligonucleotidetarget, targettpi, tpimass, massoligonucleotides, oligonucleotidescounts, countsimpurities, impuritiesrna, rnaoligo, oligosequence, sequencedeconvoluted, deconvolutedentropy, entropywere, wereagilent