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Comprehensive and Integrated Workflow for Oligonucleotide Sequence Confirmation by Agilent High-Resolution LC/Q-TOF

 

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Application Note Pharma & Biopharma Oligonucleotides Oligonucleotide Characterization by Agilent 1290 Infinity II Bio LC and 6545XT AdvanceBio LC/Q-TOF Oligonucleotide identity, impurities analysis and sequence determination using BioConfirm 12.0 target plus impurities (TPI) and sequence confirmation workflows Authors Introduction Bian…
Key words
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Application Note Biopharma/Pharma An Integrated Workflow for the Analysis of Oligonucleotides and Their Impurities by Agilent High-Resolution LC/(Q-)TOF Mass Spectrometry Separation, characterization, and relative quantitation of target oligonucleotides and their impurities Authors David L. Wong and Peter Rye Agilent Technologies,…
Key words
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Application Note BioPharma MS/MS Oligonucleotide Sequencing Using LC/Q-TOF with HILIC Chromatography Authors Guannan Li and Peter Rye Agilent Technologies, Inc. Introduction Oligonucleotides are commonly analyzed by liquid chromatography/mass spectrometry (LC/MS) in negative ion polarity mode using ion-pairing reversed‑phase (IP‑RP) methods.…
Key words
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Poster Reprint ASMS 2023 Poster number ThP 566 Oligonucleotide Characterization by Bio LC and Q-TOF Yulan Bian1, David L Wong2 1Agilent Technologies, Inc., Singapore 2Agilent Technologies, Inc., Santa Clara, CA Introduction Experimental Sample preparation Oligonucleotide (RNA) Resolution Standard was obtained…
Key words
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