Efficient Method Optimization of Semaglutide Analysis Using an Agilent 1260 Infinity II Bio Prime LC System and Blend Assist
Applications | 2024 | Agilent TechnologiesInstrumentation
Peptide therapeutics such as semaglutide play a growing role in the treatment of type 2 diabetes and obesity. Ensuring high purity and consistent impurity profiling is critical to meeting regulatory quality requirements and maintaining patient safety. High-resolution liquid chromatography methods are essential for detecting and quantifying trace-level peptide impurities.
HPLC
IndustriesPharma & Biopharma
ManufacturerAgilent Technologies
Summary
Significance of the Topic
Peptide therapeutics such as semaglutide play a growing role in the treatment of type 2 diabetes and obesity. Ensuring high purity and consistent impurity profiling is critical to meeting regulatory quality requirements and maintaining patient safety. High-resolution liquid chromatography methods are essential for detecting and quantifying trace-level peptide impurities.
Content was automatically generated from an orignal PDF document using AI and may contain inaccuracies.
Similar PDF
Simple and Efficient Purification of Semaglutide Using the Agilent 1290 Infinity II Preparative LC System
2025|Agilent Technologies|Applications
Application Note Biopharmaceuticals Simple and Efficient Purification of Semaglutide Using the Agilent 1290 Infinity II Preparative LC System Authors Abstract Chae-Won Oh Chae-Young Ryu Agilent Technologies, Inc. This application note presents a method for the efficient isolation and purification of…
Key words
semaglutide, semaglutidemau, mauwegovy, wegovyfraction, fractionozempic, ozempicpreparative, preparativemobile, mobilemin, minmodifier, modifierexcipients, excipientsacidic, acidicchae, chaetfa, tfacollection, collectionfractions
Characterization of Synthetic Peptide Drug and Impurities using High-Performance Liquid Chromatography (HPLC) and Liquid Chromatography/Mass Spectrometry (LC/MS)
2025|Agilent Technologies|Posters
Characterization of Synthetic Peptide Drug and Impurities using High-Performance Liquid Chromatography (HPLC) and Liquid Chromatography/Mass Spectrometry (LC/MS) 1D Column Column Agilent AdvanceBio Peptide Mapping 120Å, 2.1 x 150mm, 2.7 µm 0.4 mL/min Injection volume 20 μL Column temperature A) B)…
Key words
daltons, daltonsozempic, ozempicabundance, abundancesemaglutide, semaglutidemass, massamino, aminoopa, opasynthetic, syntheticcounts, countstime, timesource, sourceacid, acidmin, mininfinitylab, infinitylabapi
Workflow Solutions for Peptide Therapeutics - Application Compendium
2025|Agilent Technologies|Guides
Workflow Solutions for Peptide Therapeutics Application Compendium Table of Contents Introduction4 An emerging class of peptide therapeutics: GLP-15 Analytical advances in peptide therapeutics5 Key analyses for synthetic and recombinant peptide therapeutics 6 Types of impurities in peptide therapeutics 7 Agilent…
Key words
peptide, peptidereturn, returncontents, contentsadvancebio, advancebiotable, tableliraglutide, liraglutideagilent, agilentanalysis, analysisinfinitylab, infinitylabsemaglutide, semaglutideimpurities, impuritiessynthetic, syntheticmsd, msdtherapeutics, therapeuticsnotes
Confirmation of Peptide-Related Impurity Intact Mass Using Agilent 1290 Infinity II Bio 2D-LC and InfinityLab LC/MSD XT
2024|Agilent Technologies|Applications
Application Note Biopharmaceuticals Confirmation of Peptide-Related Impurity Intact Mass Using Agilent 1290 Infinity II Bio 2D-LC and InfinityLab LC/MSD XT Author Chae-Young Ryu Agilent Technologies, Inc. Abstract This application note presents the analysis of peptide-related impurities for Semaglutide using an…
Key words
abundance, abundancesemaglutide, semaglutiderelative, relativemass, massimpurities, impuritiespeptide, peptidemin, mintime, timedegradation, degradationmau, maumsd, msdweights, weightsdaltons, daltonsthreshold, thresholdcut
