Clarity Control Module AXCEND FOCUS LC

Importance of the Topic

High‐performance liquid chromatography (HPLC) remains a cornerstone technique across pharmaceutical, environmental and food testing laboratories. The integration of portable HPLC devices with advanced software control enables greater flexibility, reliable data acquisition and centralized method management. Networking of field‐deployable systems expands analytical capabilities beyond the traditional lab bench.

Objectives and Overview

This summary focuses on the installation, configuration and operation of the Axcend Focus LC portable HPLC when controlled via Clarity chromatography software (version 8.8 and above). It outlines the required hardware and software prerequisites, step‐by‐step setup procedures, method development interface and troubleshooting strategies to ensure robust instrument performance.

Methodology and Instrumentation

Software requirements include Clarity C50 with the LC control module and Agilent Instrument Control Framework (ICF) version compatible with .NET 4.8 or higher. Supported operating systems are Windows 10 and 11 (64-bit). Hardware prerequisites involve a LAN interface on the PC, correct firmware version on the Focus LC and direct network connectivity, preferably via cross-over cable.

Used Instrumentation

The Axcend Focus LC system is a compact, LAN-enabled HPLC unit designed for field or lab use. It interfaces with Clarity software via Agilent ICF, allowing full control of pumps, autosampler triggers and auxiliary signals. The system monitor provides real‐time diagnostics, while method setup panels handle sample injection, gradient programming, flow rate, pressure limits and detector channels.

Main Results and Discussion

The installation workflow ensures that Clarity automatically installs or updates Agilent ICF to the correct version. Network configuration and firewall checks are critical for reliable communication. Within Clarity’s System Configuration, the Focus LC module is added, assigned to the LC instrument type and linked to its IP address. Method Setup dialogs enable sample port assignment, multi‐injection control and configuration of acquisition parameters and auxiliary signals. A dedicated Device Monitor window offers online status and help access.

Benefits and Practical Applications

Direct software control via LAN streamlines method deployment and reduces operator intervention. Centralized instrument methods and audit‐ready logs enhance data integrity in regulated environments. Portable HPLC operation broadens analytical reach for on‐site quality checks, environmental surveys and process monitoring in remote manufacturing facilities.

Future Trends and Potential Applications

Advances in IoT connectivity and cloud‐based data management will drive remote instrument monitoring and predictive maintenance. Integration of AI‐driven method optimization and automated troubleshooting will further improve throughput. Expansion of portable systems into field diagnostics and point‐of‐care testing is anticipated.

Conclusion

The Axcend Focus LC integration with Clarity software provides a user‐friendly, networked HPLC solution that meets modern laboratory and field analysis demands. Comprehensive installation guidance, method configuration tools and troubleshooting resources ensure effective deployment and reliable performance.

Reference

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