Clarity Control Module CTC PAL

Importance of Controlled Automation in Chromatographic Sampling

Effective and reliable sample introduction is a cornerstone of modern analytical chemistry. The integration of autosamplers such as the CTC PAL series into chromatographic workflows enhances reproducibility, minimizes human error and maximizes throughput. Full software control of sample preparation aligns injection parameters with data acquisition, ensuring that key method details are recorded in each chromatogram for quality assurance and regulatory compliance.

Objectives and Overview of the Document

This document outlines the setup, configuration and operation of CTC PAL autosamplers under the Clarity chromatography station. It covers system requirements, hardware connections, software installation, method development, sequence management and advanced customization. Detailed guidance is provided for LC-, GC- and SPME-based injection cycles, including headspace and fiber-based sampling.

Methodology and Instrumentation

Instrumentation

• CTC LC PAL, GC PAL, Combi PAL and PAL-xt family autosamplers
• Serial RS-232 interface or LAN (Ethernet) connection for direct communication
• Clarity software (Microsoft .NET Framework 4 required) with AS control module
• Synchronization via digital I/O between autosampler and detector

Method configuration involves defining the COM port or IP address, syringe volume, tray layouts and enabling headspace overlap. The hardware configuration dialog maps physical vials to sequence positions and detects installed syringe and tray types.

Main Features and Discussion

Clarity’s Method Setup – AS tab offers preconfigured injection programs for GC, LC, headspace and various SPME modes. Key adjustable parameters include air strokes, solvent and sample washes, fill/injection speeds, delays, incubation temperatures and times, agitation settings, needle penetration depths and desorption cycles. The sequence editor facilitates external start synchronization, vial range specification and multi-vial injections while preserving method metadata in every run.

Benefits and Practical Applications

• Improved precision and repeatability of injections across analytical runs
• Seamless integration of complex sample prep procedures (e.g., heated SPME, headspace overlap)
• Full traceability of autosampler parameters within chromatographic data files
• Scalability for high-throughput environments and automated QA/QC workflows

Future Trends and Potential Applications

• Enhanced networked autosampler fleets with centralized monitoring and diagnostics
• Expanded custom injection cycle libraries via SDK and cycle editor tools
• Real-time remote control and data logging for distributed laboratory setups
• Advanced error-handling and predictive maintenance driven by communication log analysis

Conclusion

Direct control of CTC PAL autosamplers through Clarity streamlines chromatographic sample management, from routine LC/GC injections to sophisticated SPME workflows. The combination of rich method parameterization, flexible hardware interfaces and integrated data capture supports reliable, high-throughput analyses and ensures that each injection is fully documented.

Reference

DataApex Ltd. CTC PAL Clarity Control Module Manual, Code/Rev. M063/90B, November 2024.