Clarity Control Module KONTRON 360/560

Importance of Automated HPLC Sample Handling

Automated sample injection is critical to improve throughput, precision and reproducibility in modern analytical chemistry workflows. The integration of autosamplers with chromatography software reduces manual errors, ensures accurate timing and supports high sample volumes.

Objectives and Overview

This application note presents the Kontron 360/560 Control Module for DataApex Clarity software. It details requirements, installation, configuration, and operation of the autosampler under direct software control. The document targets analytical scientists seeking streamlined HPLC sample management.

Methodology and Instrumentation

• Kontron 360/560 autosampler controlled via serial RS232 interface
• DataApex Clarity Chromatography Station with AS Control Module (p/n A26)
• DB9F–DIN5M communication cable (p/n SK09) and optional MultiCOM adapter
• DataApex UNI driver Ruby script (KONTRON360_560AS.RB)
• Clarity software configured via System Configuration and DataApex UNI Setup dialogs

Main Findings and Discussion

• Seamless parameter transfer from Clarity to the autosampler, including air gap, sample volume and wash routines
• Real-time device monitoring and state management (Remote/Local modes) through the Clarity interface
• Automated method reporting captures all injection settings for audit trails
• Troubleshooting tools enable detailed RS232 communication logging via COMMDRV.INI configuration

Benefits and Practical Applications

• Enhanced laboratory efficiency by automating repetitive injection tasks
• Improved data integrity through integrated control and reporting
• Flexibility to adapt wash protocols and synchronization inputs for diverse workflows
• Reduced downtime by leveraging built-in diagnostics and automatic device detection

Future Trends and Opportunities

• Transition to networked and USB-based communication to replace legacy RS232
• Integration with cloud-based LIMS and real-time remote monitoring
• Adoption of AI-driven method optimization and predictive maintenance
• Expansion of modular driver frameworks supporting emerging autosampler designs

Conclusion

The Kontron 360/560 Control Module for Clarity software offers a robust solution for fully automated sample injection in HPLC systems. It enhances operational consistency, simplifies method setup and provides comprehensive reporting. These capabilities support modern analytical laboratories in achieving higher throughput and data reliability.

References

• DataApex Ltd. Kontron 360/560 Clarity Control Module Manual, Revision M156/90C, 2024